Results 271 to 280 of about 83,545 (299)

The Death-domain Fold of the ASC PYRIN Domain, Presenting a Basis for PYRIN/PYRIN Recognition [PDF]

Journal of Molecular Biology, 2003
The PYRIN domain is a conserved sequence motif identified in more than 20 human proteins with putative functions in apoptotic and inflammatory signalling pathways. The three-dimensional structure of the PYRIN domain from human ASC was determined by NMR spectroscopy. The structure determination reveals close structural similarity to death domains, death
Edgar Dahl, Eike Staub, Gottfried Otting
exaly   +4 more sources

The effect of colchicine on pyrin and pyrin interacting proteins

Journal of Cellular Biochemistry, 2012
AbstractMEFV which encodes pyrin, cause familial Mediterranean fever (FMF), the most common auto‐inflammatory disease. Pyrin is believed to be a regulator of inflammation, though the nature of this regulatory activity remains to be identified.
Ekim Z Taskiran, Engin Yılmaz, Banu Balci-Peynircioglu   +2 more
exaly   +4 more sources

Recent Insights in Pyrin Inflammasome Activation: Identifying Potential Novel Therapeutic Approaches in Pyrin-Associated Autoinflammatory Syndromes

Journal of Clinical Immunology, 2023
Pyrin is a cytosolic protein encoded by the MEFV gene, predominantly expressed in innate immune cells. Upon activation, it forms an inflammasome, a multimolecular complex that enables the activation and secretion of IL-1β and IL-18. In addition, the Pyrin inflammasome activates Gasdermin D leading to pyroptosis, a highly pro-inflammatory cell death ...
Jeroen C H Van Der Hilst, Andy Wullaert
exaly   +5 more sources

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Inducing Pyroptosis Via the Pyrin Inflammasome

2023
The pyrin inflammasome detects bacterial toxins and effectors that inhibit RhoA GTPases and triggers inflammatory cytokine release and a fast cell death termed pyroptosis. In addition, various endogenous molecules, drugs, synthetic molecules, or mutations can trigger pyrin inflammasome activation.
Bronnec, Pauline, Sousa, Jeremy, Henry, Thomas   +2 more
openaire   +3 more sources

Functional Assessment of Disease-Associated Pyrin Variants

2022
The pyrin inflammasome detects effectors and toxins that inhibit RhoA GTPases and triggers inflammatory cytokines release and a fast cell death termed pyroptosis. Ancient plague pandemics in the Mediterranean basin have selected in the human population pyrin variants that can trigger an autoinflammatory disease termed familial Mediterranean fever (FMF).
Chirita, Daria, Jamilloux, Yvan, Henry, Thomas, Magnotti, Flora   +3 more
openaire   +4 more sources

CATERPILLERs, pyrin and hereditary immunological disorders

Nature Reviews Immunology, 2006
The newly described CATERPILLER family (also known as NOD-LRR or NACHT-LRR) is comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This family has gained rapid prominence because of its demonstrated and anticipated roles in immunity, cell death and growth, and diseases.
Jenny P-Y, Ting, Daniel L, Kastner, Hal M, Hoffman   +2 more
openaire   +2 more sources

Pyrin variants can burn out the plague

Nature Reviews Immunology, 2020
Mutations in pyrin that cause the autoinflammatory disease familial Mediterranean fever may have been selected for during plague pandemics.
openaire   +2 more sources

Corneal Toxicity of the Pediculocide A-200 Pyrinate

Archives of Ophthalmology, 1962
Five patients who had acute chemical erosion of the cornea secondary to the pediculocide A-200 Pyrinate * have been seen at the Massachusetts Eye and Ear Infirmary in the past 8 months. The symptoms were acute and severe, but complete healing ensued. All patients were between ages 3 and 8 years, and all had recently applied A-200 Pyrinate to the head ...
R D, REINECKE, R S, KINDER
openaire   +2 more sources

An alternative path for pyrin

Science Signaling, 2016
Mutations associated with an autoimmune disorder enable cells to assemble pyrin inflammasomes independently of microtubules.
openaire   +1 more source