Results 91 to 100 of about 195,629 (388)

Simvastatin inhibits TLR8 signaling in primary human monocytes and spontaneous TNF production from rheumatoid synovial membrane cultures [PDF]

, 2015
Simvastatin has been shown to have anti-inflammatory effects that are independent of its serum cholesterol lowering action, but the mechanisms by which these anti-inflammatory effects are mediated have not been elucidated.
A Gierut, A Hilgendorff, AA Ajibade, BI Gavrila, BP Leung, C Arnaud, C Guiducci, C Guijarro, E Munro, EH Choy, FL Zhang, FM Brennan, FM Brennan, FX Zhang, G Falgarone, H Kanda, H Kanda, H Lin, H Methe, H Okamoto, H Radner, H Wesche, H Xu, I Zelvyte, J Qin, Jason Ferdjani, K Chaabo, KA Fitzgerald, KA Fitzgerald, KH Costenbader, KI Paraskevas, L Liu, LA O’Neill, Lisa Mullen, LM Mullen, M Khoury, M Ortego, M Yamamoto, M Yoshida, MA Gonzalez-Gay, QQ Huang, S Alzabin, S Doornum Van, Sandra Sacre, SL Chinault, SM Sacre, T Mosmann, TT Tang, U Schonbeck   +48 more
core   +1 more source

White Light Generation From YAG:Ce‐Doped Phosphate Glass‐Based Composite Fibers

Advanced Optical Materials, EarlyView.
The first white‐light‐emitting composite fiber based on YAG:Ce3+ phosphors in phosphate glass is developed. The glass composition is custom‐engineered to enhance thermal stability and to match YAG:Ce3+ refractive index, ensuring composite transparency.
Khaldoon Nasser, Hùng Nguyên Trân, Arjun Vakkada Ramachandran, Mikko Närhi, Turkka Salminen, Catherine Boussard‐Plédel, Johann Troles, Tian‐Long Guo, Matthieu Roussey, Laeticia Petit   +9 more
wiley   +1 more source

Human neutrophil clearance of bacterial pathogens triggers anti-microbial gamma delta T cell responses in early infection [PDF]

, 2011
Human blood Vc9/Vd2 T cells, monocytes and neutrophils share a responsiveness toward inflammatory chemokines and are rapidly recruited to sites of infection.
A Boëdec, A Matsushima, A Reichenberg, AC Brown, AC Hayday, AC Hayday, Amanda C. Brown, B Altincicek, B Moser, Bernhard Moser, C Agrati, C Belmant, C De Santo, C Münz, CC Szeto, Chan-Yu Lin, CM Bunke, Colin Hill, Cormac G. M. Gahan, CT Morita, CT Spencer, CT Weaver, D Vermijlen, David W. Johnson, DI Godfrey, DJ Pennington, DK Kim, E Oldfield, E. John Wherry, F Annunziato, F Dieli, F Sallusto, G Sarikonda, Gareth W. Roberts, GW Roberts, H Jomaa, H Jomaa, H Li, H Wang, H Wei, I Müller, J Feurle, J Mookerjee-Basu, James A. Chess, JF Bukowski, JJ O'Shea, John D. Williams, JS Savill, K Pietschmann, KJ Puan, KK Kumarasamy, KM Murphy, L Troidle, M Begley, M Begley, M Blunden, M Bonneville, M Brandes, M Eberl, M Eberl, M Eberl, M Eberl, M Eberl, M Fahim, M Kistowska, M Krishnan, M Pelletier, M Rohmer, MA Missinou, Mark A. Toleman, Martin S. Davey, Matthias Eberl, MC Devilder, MC Devilder, MI Hirsh, MJ Llewelyn, N Nathan, N Topley, Nicholas Topley, O Devuyst, P Choi, P Constant, PS Evans, R Medzhitov, RE Rojas, RM McLoughlin, S Amslinger, S Mujais, Simon J. Davies, Sinéad Heuston, SJ Davies, SM Hurst, SR Gill, T Ganz, Tanya Parish, TR Walsh, TW Rice, W Holtmeier, Y Kato, Y Neu, Y Tanaka, Y Zhang   +101 more
core   +5 more sources

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Vacuolar H+-pyrophosphatase AVP1 is involved in amine fungicide tolerance in Arabidopsis thaliana and provides tridemorph resistance in yeast

Frontiers in Plant Science, 2016
Amine fungicides are widely used as crop protectants. Their success is believed to be related to their ability to inhibit postlanosterol sterol biosynthesis in fungi, in particular sterol-Δ8,Δ7-isomerases and sterol-Δ14-reductases, with a concomitant ...
Agustín eHernández, Agustín eHernández, Rosana eHerrera-Palau, Juan Manuel Madroñal, Tomás eAlbi, Guillermo eLopez-Lluch, Jose Roman Perez-Castiñeira, Plácido eNavas, Federico eValverde, Aurelio eSerrano   +9 more
doaj   +1 more source

Silicate-, Magnesium Ion-, and Urea-Induced Prebiotic Phosphorylation of Uridine via Pyrophosphate; Revisiting the Hot Drying Water Pool Scenario

Life, 2020
The availability of nucleotides on the early Earth is of great significance for the origin of a self-replicating system capable of undergoing evolution. We hereby report the successful phosphorylation reactions of the nucleoside uridine under heating in ...
Maheen Gull, Arthur Omran, Tian Feng, Matthew A. Pasek   +3 more
doaj   +1 more source

A reservoir of 'historical' antibiotic resistance genes in remote pristine Antarctic soils [PDF]

, 2018
Background: Soil bacteria naturally produce antibiotics as a competitive mechanism, with a concomitant evolution, and exchange by horizontal gene transfer, of a range of antibiotic resistance mechanisms.
Bezuidt, Oliver KI, Cowan, Don A, Makhalanyane, Thulani P, Pierneef, Rian, Van de Peer, Yves, Van Goethem, Marc W   +5 more
core   +2 more sources

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

The translational value of calcium pyrophosphate deposition disease experimental mouse models

Frontiers in Medicine
The deposition of calcium pyrophosphate (CPP) crystals in joint tissues causes acute and chronic arthritis that commonly affect the adult and elderly population.
Roberto Luisetto, Anna Scanu, Anna Scanu
doaj   +1 more source

Alkaline Phosphatases Account for Low Plasma Levels of Inorganic Pyrophosphate in Chronic Kidney Disease

Frontiers in Cell and Developmental Biology, 2020
IntroductionPatients on dialysis and kidney transplant recipients (KTR) present the syndrome of mineral and bone disorders (MBD), which share common traits with monogenic calcifying diseases related to disturbances of the purinergic system.
Audrey Laurain, Audrey Laurain, Audrey Laurain, Isabelle Rubera, Christophe Duranton, Frank Rutsch, Yvonne Nitschke, Elodie Ray, Sandor Vido, Antoine Sicard, Antoine Sicard, Georges Lefthériotis, Georges Lefthériotis, Georges Lefthériotis, Guillaume Favre, Guillaume Favre, Guillaume Favre   +16 more
doaj   +1 more source