Results 141 to 150 of about 195,629 (388)

Regulated to respond: dual localization and dynamic control of AVP1 in plant carbon partitioning

Frontiers in Plant Science
Arabidopsis Vacuolar Pyrophosphatase 1 (AVP1), a conserved type I proton-pumping pyrophosphatase (H+-PPase), was characterized as tonoplast localized with a role in acidifying the lumen and removing cytosolic pyrophosphate (PPi), a byproduct of ...
Roberto Gaxiola, Kendal D. Hirschi
doaj   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

The Effect of Asfotase Alfa on Plasma and Urine Pyrophosphate Levels and Pseudofractures in a Patient With Adult‐Onset Hypophosphatasia [PDF]

, 2023
Naoko Hidaka, Hiroaki Murata, Kanako Tachikawa, Keiichi Osaki, Takashi Sekiyama, Yuka Kinoshita, Hajime Katô, Yoshitomo Hoshino, Soichiro Kimura, Takashi Sunouchi, So Watanabe, Masaomi Nangaku, Noriko Makita, Toshimi Michigami, Nobuaki Ito   +14 more
openalex   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Vascular Calcification: A Passive Process That Requires Active Inhibition

Biology
The primary cause of worldwide mortality and morbidity stems from complications in the cardiovascular system resulting from accelerated atherosclerosis and arterial stiffening.
Ricardo Villa-Bellosta
doaj   +1 more source

Engineering of 2‐ketoacid Decarboxylases for Production of Isobutanol and Other Fusel Alcohols in Saccharomyces cerevisiae

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Isobutanol is a fusel alcohol that can be produced microbially for use as a biofuel or upgraded into sustainable aviation fuel (SAF). A key enzyme in the isobutanol biosynthetic pathway is 2‐ketoacid decarboxylase (KDC), which irreversibly decarboxylates 2‐ketoisovalerate (KIV) to yield isobutyraldehyde.
Joshua J. Dietrich, Maelia Dziedzic, Jia Sun, Sri Harsha Adusumilli, Carla Gonçalves, Chris Todd Hittinger, Brian F. Pfleger   +6 more
wiley   +1 more source

Studying the Outcomes and Mechanisms of Carbocationic Rearrangements Using Algorithm‐Augmented Experimentation

ChemistryEurope, EarlyView.
HopCat, a hybrid algorithm combining rule‐based transformations with quantum‐informed kinetics, can be applied to acid‐catalyzed terpenoid rearrangements. In synergy with human chemists and nuclear magnetic resonance analysis, it facilitates product assignment, candidate selection, and reconstruction of complex mechanistic pathways.
Louis P. J.‐L. Gadina, Sebastian Baś, Ahmad Makkawi, Yasemin Bilgi‐Gadina, Tomasz Klucznik, Wiktor Beker, Bartosz A. Grzybowski   +6 more
wiley   +1 more source

Pyrophosphate Regulates Multilineage Differentiation in Stem Cells From Human Exfoliated Deciduous Teeth

Clinical and Experimental Dental Research
Background To explore the cellular behavior of stem cells derived from human exfoliated deciduous teeth (SHED) in response to inorganic pyrophosphate (PPi).
Ravipha Suwittayarak, Nunthawan Nowwarote, Chatvadee Kornsuthisopon, Waleerat Sukarawan, Brian L. Foster, Hiroshi Egusa, Thanaphum Osathanon   +6 more
doaj   +1 more source

Recent Progress of Na3MnTi(PO4)3 Cathode for Sodium‐Ion Batteries: Mechanism, Synthesis, and Optimization Strategy

Carbon Energy, EarlyView.
Na3MnTi(PO4)3 (NMTP) combines the inherent structural stability and high‐voltage characteristics of NASICON‐type frameworks, positioning it as a highly promising cathode candidate for practical sodium‐ion batteries. To date, substantial progress has been achieved in NMTP research, and this article provides a comprehensive review of its development and ...
Shanshan Lv, Peng Wei, Fan Wu, Kang Liang, Fangyuan Cheng, Jian Peng, Yurong Ren   +6 more
wiley   +1 more source

Stains Induce Apoptosis and Autophagy in Primary and Transformed Mast Cells [PDF]

, 2016
Statin drugs are widely employed in the clinic to reduce serum low density lipoproteins (LDLs) in patients with hypocholesteremia. In addition to their cholesterol-lowering effects through HMG CoA reductase antagonism, isoprenyl lipids necessary for ...
Paez, Patrick A
core   +1 more source