Results 161 to 170 of about 101,444 (302)

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

open access: yesThe FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu   +2 more
wiley   +1 more source

Effects of GLP‐1 agonists on the gut microbiota in type 2 diabetes mellitus: a systematic review

open access: yesThe FEBS Journal, EarlyView.
This systematic review evaluated 17 studies (12 preclinical and five clinical) on GLP‐1 receptor agonists in type 2 diabetes, demonstrating effects on the gut microbiota and metabolic improvement. The studies showed an increase in Bacteroidetes, Lactobacillus, and Akkermansia, and a reduction in Firmicutes.
Ranicleide Santos Dantas   +11 more
wiley   +1 more source

Common pathways and outliers in glucose catabolism across Trypanosomatidae

open access: yesThe FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes   +5 more
wiley   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

open access: yesThe FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén   +11 more
wiley   +1 more source

Circulating Levels of Inorganic Pyrophosphate Influence the Risk and Clinical Outcomes in Calciphylaxis. [PDF]

open access: yesJACC Adv
Nigwekar SU   +9 more
europepmc   +1 more source

Actomyosin の溶解性と Pyrophosphate I

open access: yes
1) Pyrophosphate dissolves isoelectric precipitate of Actomyosin (AM). This effect of pyrophosphate is intensified more markedly with the increase of concentration of pyrophosphate and with the increase of ionic strength of AM-solution under constant ...
若狭, 智惠子
core  

Structural and mutational analysis of Methanosarcina mazei prenylated FMN synthase reveals the basis of its unique prenyl donor substrate specificity

open access: yesThe FEBS Journal, EarlyView.
Some prenylated flavin mononucleotide (prFMN) synthases exceptionally prefer dimethylallyl phosphate (DMAP) over dimethylallyl diphosphate (DMAPP), which is a common prenyl donor substrate for many prenyltransferases. Structural and mutagenic analyses of Methanosarcina mazei prFMN synthase, which prefers DMAP but can also accept DMAPP, elucidated its ...
Sou Fukuhara   +5 more
wiley   +1 more source

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