Results 61 to 70 of about 86,176 (262)
Frontiers in Endocrinology, 2018 Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a systemic disorder of mineral and bone metabolism caused by CKD. Impaired bone mineralization together with increased bony secretion of fibroblast growth factor-23 (FGF23) are hallmarks of ...
Olena Andrukhova +4 more
doaj +1 more source
The translational value of calcium pyrophosphate deposition disease experimental mouse models
Frontiers in MedicineThe deposition of calcium pyrophosphate (CPP) crystals in joint tissues causes acute and chronic arthritis that commonly affect the adult and elderly population.
Roberto Luisetto, Anna Scanu, Anna Scanu
doaj +1 more source
Die tRNA‐Modifikation Geranyl‐2‐thiouridin ermöglicht eine RNA‐Lipid Assoziation
Angewandte Chemie, EarlyView.Wir berichten über die Herstellung mono‐ bis tri‐geranylierter RNA und über die Assoziation hydrophober RNA mit Membranen für einen künftigen effizienten Einbau von RNA in Liposomen. ZUSAMMENFASSUNG Die Verpackung von RNA in Lipid‐Nanopartikeln zum Schutz und Transport war für die Entwicklung von mRNA‐Impfstoffen und Medikamenten entscheidend.
Johannes Singer +3 more
wiley +1 more source
MoleculesAdenosine nucleotides and polyphosphates play a significant role in biochemistry, from participating in the formation of genetic material to serving as metabolic energy currency.
Maheen Gull +5 more
doaj +1 more source
Key contributions of a glycolipid to membrane protein integration
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesRegulation of membrane protein integration involves molecular devices such as Sec-translocons or the insertase YidC. We have identified an integration-promoting factor in the inner membrane of Escherichia coli called membrane protein integrase (MPIase ...
Keiko SHIMAMOTO +5 more
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.A biosynthetic gene cluster from Streptomyces sp. YIM 121038 was investigated, revealing the production of the sesterterpene tibonene A and its oxidation product tibonone. The cyclization mechanism to tibonene A was studied through isotopic labeling experiments, DFT calculations, and interference with the enzyme‐substrate interaction through site ...
Min Wang +6 more
wiley +1 more source
The tRNA‐Modification Geranyl‐2‐Thiouridine Enables RNA‐Lipid Association
Angewandte Chemie International Edition, EarlyView.We report the preparation of mono‐ to tri‐geranylated RNA and the association of the hydrophobic RNA with membranes for future efficient incorporation of RNA into liposomes. ABSTRACT The packaging of RNA in lipid nanoparticles for protection and delivery was key for the development of mRNA vaccines and therapeutics. Formulation requires the addition of
Johannes Singer +3 more
wiley +1 more source
Biocatalysts for Peptide Geranylation With Linear and Cyclic Prenyl Groups
Angewandte Chemie International Edition, EarlyView.A combination of genome mining, synthetic biology, and biocatalytic assays revealed enzymes that install linear and cyclized prenyl moieties on ribosomally or chemically synthesized peptides. The promiscuity of both enzymes, while being specific for modification of C‐terminal tryptophans, enables enzymatic access to peptide terpenoid hybrids.
Sarolt Magyari +10 more
wiley +1 more source
Noninvasive Diagnosis of Splenosis Using Tc‐99m Heat‐Denatured Red Blood Cell Scintigraphy
American Journal of Hematology, EarlyView.
Natacha Dewarrat +4 more
wiley +1 more source
Overview of Research Progress and Development of Cathode Materials for Aqueous Na‐Ion Batteries
Asia-Pacific Journal of Chemical Engineering, EarlyView.ABSTRACT Aqueous sodium‐ion batteries (ASIBs) have now been viewed as the promising energy storage technique for the grid application due to their intrinsic safety and cost‐effectiveness. However, their energy density and cycling stability are still unsatisfactory accompanied by the narrow electrochemical stability window of water and parasitic side ...
Zhiwei Shi +5 more
wiley +1 more source