Results 101 to 110 of about 63,272 (185)
Induction of Pyroptosis and Its Implications in Cancer Management
Frontiers in Oncology, 2019 Pyroptosis is a gasdermins mediated programmed cell death, which has been widely studied in inflammatory disease models. Recently, there are growing evidences that pyroptosis can be chemically induced in cancer cells without any bacterial or viral ...
Yan-Yang Wang +4 more
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Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer
Journal for ImmunoTherapy of CancerBackground Despite advancements in treatment modalities, several patients with colorectal cancer (CRC) remain unresponsive to immune checkpoint inhibitor therapy.
Tao Zhang +12 more
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Pyroptosis, gasdermins and allergic diseases
AllergyAbstractPyroptosis is an inflammatory form of programmed cell death that is distinct from necrosis and apoptosis. Pyroptosis is primarily mediated by the gasdermin family of proteins (GSDMA‐E and PVJK), which, when activated by proteolytic cleavage, form pores in the plasma membrane, leading to cell death.
Ronald Allan Panganiban +2 more
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Bioactive MaterialsNanoliposomes have a broad range of applications in the treatment of autoimmune inflammatory diseases because of their ability to considerably enhance drug transport. For their clinical application, nanoliposomes must be able to realize on-demand release of drugs at disease sites to maximize drug-delivery efficacy and minimize side effects.
Kaiwang Xu +21 more
openaire +3 more sources
Gasdermin D is required for pyroptosis and secretion of interleukin-1β [PDF]
, 2016 炎性小体是细胞内由caspase-1，ASC，NALP等组成的蛋白复合体，也是先天免疫系统的一个重要组成。炎性小体被激活后会促进白介素1β（IL-1β）和IL-18的剪切与分泌，并触发细胞焦亡的发生。细胞焦亡是近年来发现并证实的一种新的程序性细胞死亡方式，其特征为依赖于caspase-1，并伴随有促炎症因子的释放。尽管其在先天免疫和内毒素休克方面扮演着重要角色，但细胞焦亡被诱导发生的机制仍不清楚。本文通过基于CRISPR-Cas9的基因敲除方法鉴定到了gasderminD（GSDMD ...
万浩强
core
Translational PsychiatryMelatonin improves chronic stress-induced hippocampal damage and depression-like behaviors, but the mechanism needs further study. This study was to explore the mechanism of melatonin inhibiting microglia pyroptosis.
Zhicheng Gao +6 more
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Nucleic acid sensors and programmed cell death [PDF]
, 2020 Liverpool, Layal +2 more
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Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunities
Biomarker ResearchRemarkable advances have been achieved following discoveries that gasdermins are the executioners of pyroptosis. The pyroptotic process consists a subcellular permeabilization phase and a cell lysis phase, the latter of which is irreversible.
Rui Miao +7 more
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Pharmacological ResearchInflammatory diseases, including infectious diseases, diabetes-related diseases, arthritis-related diseases, neurological diseases, digestive diseases, and tumor, continue to threaten human health and impose a significant financial burden despite ...
Ri-Wen +4 more
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