Results 111 to 120 of about 67,070 (304)

Cryoablation Activates the cGAS–STING‐CXCL10 Axis in Macrophages to Enhance Anti‐Tumor Immunity in NSCLC

Advanced Science, EarlyView.
Tumor dsDNA released by cryoablation is taken up by macrophages, activating the cGAS‐STING signaling pathway. This leads to an expansion of the CXCL10+ macrophage pool and increased secretion of CXCL10, which in turn recruits CXCR3+ T cells from draining lymph nodes into the tumor microenvironment to exert anti‐tumor effects.
Xinxin Zhi, Zhengcao Xing, Libo Luo, Jiale Wang, Xinyu Liu, Jia Yu, Jizhong Yin, Bin Chen, Yiwei Liu, Hui Sun, Guanghui Gao, Lei Wang, Xiaoxia Chen, Fei Li, Hu Ma, Lin Wang, Shuo Yang, Shengxiang Ren   +17 more
wiley   +1 more source

ROS induced pyroptosis in inflammatory disease and cancer

Frontiers in Immunology
Pyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent death, plays a crucial role in diseases such as stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various
Jingsong Wang, Ziyong Wu, Min Zhu, Yang Zhao, Jingwen Xie, Jingwen Xie   +5 more
doaj   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

Embryo‐Derived Cathepsin B Promotes Implantation and Decidualization by Activating Pyroptosis

Advanced Science
Embryo implantation and decidualization are crucial for a successful pregnancy. How the inflammatory response is regulated during these processes is undefined. Pyroptosis is an inflammatory form of cell death mediated by gasdermin D (GSDMD).
Meng‐Yuan Li, Ying Wu, Hao‐Lan Tang, Ying Wang, Bo Li, Yu‐Ying He, Gui‐Jun Yan, Zeng‐Ming Yang   +7 more
doaj   +1 more source

SGLT2 inhibition attenuates diabetic tubulopathy by suppressing SGK1-mediated pyroptosis

Frontiers in Endocrinology
BackgroundDiabetic tubulopathy is increasingly recognized as a pivotal contributor to diabetic kidney disease (DKD) progression. Excessive pyroptosis of renal tubular epithelial cells exacerbates inflammation and tissue injury.
Xu Shi, Xu Shi, Wei Zou, Xuehong Li, Xuehong Li, Sirui Liu, Sirui Liu, Tiantian Hu, Tiantian Hu, Qiong Li, Qiong Li, Ting Zhang, Ting Zhang, Lei Chen, Lei Chen, Sumin Wu, Sumin Wu, Cheng Wang, Cheng Wang, Yongjie Jin, Yongjie Jin   +20 more
doaj   +1 more source

Triggering Pyroptosis in Cancer

Biomolecules
Pyroptosis is an inflammatory programmed cell death recently identified as a crucial cellular process in various diseases, including cancers. Unlike other forms of cell death, canonical pyroptosis involves the specific cleavage of gasdermin by caspase-1, resulting in cell membrane damage and the release of the pro-inflammatory cytokines IL-1β and IL-18.
Daniel E. Johnson, Zhibin Cui
openaire   +3 more sources

Pyroptosis in Antiviral Immunity

, 2019
Pyroptosis is a form of lytic, programmed cell death that functions as an innate immune effector mechanism to facilitate host defense against pathogenic microorganisms, including viruses. This type of proinflammatory cell death is orchestrated by proteolytic activation of human or mouse caspase-1, mouse caspase-11 and human caspase-4 and caspase-5 in ...
Teneema, Kuriakose, Thirumala-Devi, Kanneganti   +1 more
openaire   +3 more sources

Reinforcing Calcium Overload via Inflammation‐Mediated Targeting to Amplify Pyroptosis and Antitumor Immunity

Advanced Science, EarlyView.
A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu, Yang Liu, Qin Fan, Jinqiao Zhang, Kexin Wen, Boyu Yuan, Xianzhou Cai, Ziliang Dong, Lianhui Wang   +8 more
wiley   +1 more source