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New prospects of cancer therapy based on pyroptosis and pyroptosis inducers
Apoptosis, 2023Pyroptosis is a gasdermin-mediated programmed cell death (PCD) pathway. It differs from apoptosis because of the secretion of inflammatory molecules. Pyroptosis is closely associated with various malignant tumors. Recent studies have demonstrated that pyroptosis can either inhibit or promote the development of malignant tumors, depending on the cell ...
Qiaoyun, Chen +3 more
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Bioorthogonal Disruption of Pyroptosis Checkpoint for High-Efficiency Pyroptosis Cancer Therapy
Journal of the American Chemical Society, 2023Pyroptosis is an inflammatory form of programmed cell death that holds great promise in cancer therapy. However, autophagy as the crucial pyroptosis checkpoint and the self-protective mechanism of cancer cells significantly weakens the therapeutic efficiency. Here, a bioorthogonal pyroptosis nanoregulator is constructed to induce pyroptosis and disrupt
Wenting Zhang +7 more
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Ferroptosis and Pyroptosis in Epilepsy
Molecular NeurobiologyEpilepsy is sudden, recurrent, and transient central nervous system dysfunction caused by abnormal discharge of neurons in the brain. Ferroptosis and pyroptosis are newly discovered ways of programmed cell death. One of the characteristics of ferroptosis is the oxidative stress generated by lipid peroxides.
Fan Feng +3 more
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Role of pyroptosis in liver diseases
International Immunopharmacology, 2020Pyroptosis is known as a novel form of pro-inflammatory cell death program, which is exceptional from other types of cell death programs. Particularly, pyroptosis is characterized by Gasdermin family-mediated pore formation and subsequently cellular lysis, also release of several pro-inflammatory intracellular cytokines.
Abdullah, Al Mamun +8 more
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Inflammasome-independent pyroptosis
Current Opinion in ImmunologyGasdermins are membrane pore-forming proteins that cause pyroptosis, an inflammatory cell death in which cells burst and release cytokines, chemokines, and other host alarm signals, such as ATP and HMGB1, which recruit and activate immune cells at sites of infection and danger. There are five gasdermins in humans - gasdermins A to E.
Xing, Liu, Judy, Lieberman
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Role of gasotransmitters in pyroptosis
International Journal of Biological MacromoleculesPyroptosis is a special form of programmed cell death. Pyroptosis is triggered by inflammasomes. The main morphological change is that the cells continue to expand until the cell membrane ruptures, and then the cell contents are released, triggering a strong inflammatory response.
Hong-Jie, Li +7 more
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Science Signaling, 2020
The nuclear pool of an immune checkpoint protein promotes pyroptosis and tumor necrosis downstream of TNFα.
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The nuclear pool of an immune checkpoint protein promotes pyroptosis and tumor necrosis downstream of TNFα.
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Pyroptosis in health and disease
American Journal of Physiology-Cell PhysiologyThe field of cell death has witnessed significant advancements since the initial discovery of apoptosis in the 1970s. This review delves into the intricacies of pyroptosis, a more recently identified form of regulated, lytic cell death, and explores the roles of pyroptotic effector molecules, with a strong emphasis on their mechanisms and relevance in
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Sheng li xue bao : [Acta physiologica Sinica], 2018
Pyroptosis is a form of inflammatory programmed cell death activated by caspase-1 and caspase-4/5/11, and involves in the pathogenesis of infectious diseases and nervous system diseases. Pyroptosis is mediated by canonical inflammasome pathway and non-canonical inflammasome pathway.
Biao, Tang, Chang-Qing, Deng
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Pyroptosis is a form of inflammatory programmed cell death activated by caspase-1 and caspase-4/5/11, and involves in the pathogenesis of infectious diseases and nervous system diseases. Pyroptosis is mediated by canonical inflammasome pathway and non-canonical inflammasome pathway.
Biao, Tang, Chang-Qing, Deng
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Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
Cell, 2021Iva Hafner Bratković +2 more
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