Results 171 to 180 of about 82,547 (381)

Gasdermin D is required for pyroptosis and secretion of interleukin-1β [PDF]

, 2016
炎性小体是细胞内由caspase-1，ASC，NALP等组成的蛋白复合体，也是先天免疫系统的一个重要组成。炎性小体被激活后会促进白介素1β（IL-1β）和IL-18的剪切与分泌，并触发细胞焦亡的发生。细胞焦亡是近年来发现并证实的一种新的程序性细胞死亡方式，其特征为依赖于caspase-1，并伴随有促炎症因子的释放。尽管其在先天免疫和内毒素休克方面扮演着重要角色，但细胞焦亡被诱导发生的机制仍不清楚。本文通过基于CRISPR-Cas9的基因敲除方法鉴定到了gasderminD（GSDMD ...
万浩强
core  

Induction of Inflammasome-dependent Pyroptosis by Carbon Black Nanoparticles [PDF]

, 2011
Anna C. Reisetter, Larissa V. Stebounova, Jonas Baltrušaitis, Linda S. Powers, Amit Gupta, Vicki H. Grassian, Martha M. Monick   +6 more
openalex   +1 more source

Lactate‐Modulating Nanoreactors Facilitate Self‐Amplifying Pyroptosis and the cGAS‐STING Cascade for Potentiated Catalytic‐Immunotherapy

Advanced Science, EarlyView.
An intelligent lactate‐depleting LOCoF2 (CoF2@LOx) nanoreactor system is developed to effectively induce self‐reinforced pyroptosis and activate the cGAS‐STING signaling pathway, thereby inducing a strong immune response and enhancing the therapeutic effectiveness of catalytic immunotherapy.
Linzhu Zhang, Shumin Sun, Duo Wang, Nailin Yang, Di Wang, Jihu Nie, Zifan Pei, Juan Qin, Lei Zhang, Haidong Zhu, Liang Cheng   +10 more
wiley   +1 more source

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

Advanced Science, EarlyView.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
wiley   +1 more source

The Double-Stranded RNA Analogue Polyinosinic-Polycytidylic Acid Induces Keratinocyte Pyroptosis and Release of IL-36γ [PDF]

, 2012
Li‐Hua Lian, Katelynn A. Milora, Katherine K. Manupipatpong, Liselotte E. Jensen   +3 more
openalex   +1 more source

Intracellular Mechanical Stress‐Mediated Autophagy Cell Death via Nanospikes for Cancer Treatment

Advanced Science, EarlyView.
Nanospikes with tunable morphology at the nanoscale induce lysosomal membrane damage by generating localized mechanical stress, activating Galectin‐3 (Gal3)‐Trim16‐mediated autophagic cell death. Finite element analysis and laser‐triggered spike ablation enable precise control of intracellular force signaling and cytotoxicity, offering a ...
Yingze Li, Zihan Guo, Jiawei Fan, Ruimei Zhou, Jiayan Li, Zhixiang Hu, Weicheng Gu, Mengge Zheng, Chang Xu, Yichao Tang, Chang Chen, Yu Cheng   +11 more
wiley   +1 more source

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells [PDF]

, 2012
Seth L. Masters, Motti Gerlic, Donald Metcalf, Simon Preston, Marc Pellegrini, Joanne A. O’Donnell, Kate McArthur, Tracey M. Baldwin, Stéphane Chevrier, Cameron J. Nowell, Louise H. Cengia, Katya J. Henley, Janelle E. Collinge, Daniel L. Kastner, Lionel Feigenbaum, Douglas J. Hilton, Warren S. Alexander, Benjamin T. Kile, Ben A. Croker   +18 more
openalex   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Dendrobium Officinale‐Derived Carbon Dots Nanozymes Alleviate Colitis by Orchestrating Intestinal Mucus‐Epithelium‐Immune Barriers

Advanced Science, EarlyView.
Dendrobium officinale‐derived carbon dots (DO‐CDs) exhibiting enzyme‐mimetic activities are synthesized via a hydrothermal approach. In the colitis model, DO‐CDs effectively facilitated the repair of mucosal, epithelial, and immune barriers by upregulating the expression of mucins and tight junction proteins, as well as re‐establishing intestinal ...
Chenxi Xu, Xiaoling Huang, Zhichao Deng, Ruiying Wang, Seyedalireza Ghazimirsaeid, Li Yao, Yuanyuan Zhu, Bowen Gao, Junlong Fu, Mingxin Zhang, Mei Yang, Mingzhen Zhang   +11 more
wiley   +1 more source

Bimetallic Nanozyme Amplifier for Synergistic Ferroptosis‐Cuproptosis and Metabolic Reprogramming to Reshape Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
The Bimetallic Nanozyme Amplifier (PEG@AuCZ@CC) to maximize hydrogen peroxide production and reprogram tumor metabolism from glycolysis to oxidative phosphorylation. This shift enhances ferroptotic/cuproptotic signaling cascades and creates a glucose‐enriched but lactate‐depleted tumor microenvironment (TME), effectively overcoming immune tolerance in ...
Jianzhang Luo, Kunzhao Huang, Xiaoyuan Yi, Pei Lu, Huaying Xie, Wen Li, Qingyu Zeng, Feifei He, Duo Wang, Liyan Wang   +9 more
wiley   +1 more source