Results 181 to 190 of about 42,330 (202)

Correction: RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis. [PDF]

PLoS Pathog
Guan Z, Li H, Zhang C, Huang Z, Ye M, Zhang Y, Li S, Peng K.   +7 more
europepmc   +1 more source

Gasdermin E-mediated intestinal epithelial pyroptosis promotes chemically induced colitis in mice. [PDF]

Gastroenterol Rep (Oxf)
Wu YZ, Xie Y, Chen L, Ning L, Hu XQ, Xu XP.   +5 more
europepmc   +1 more source

Identification of pyroptosis-associated gene to predict fibrosis and reveal immune characterization in non-alcoholic fatty liver disease. [PDF]

Sci Rep
Tu S, Jing X, Bu X, Zhang Q, Liao S, Zhu X, Guo Y, Sha W.   +7 more
europepmc   +1 more source

Mechanistic Studies on the Role of IL-17/NLRP3 in Arsenic-Induced Activation of Hepatic Stellate Cells Through Hepatocyte Proptosis. [PDF]

Toxics
Hu T, Chen M, Tian S, Luo P, Zhang J.
europepmc   +1 more source

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Pyroptosis and pyroptosis-inducing cancer drugs

Acta Pharmacologica Sinica, 2022
Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals, cells undergo inflammasome assembly, GSDM cleavage, the release of proinflammatory cytokines and other cellular contents, eventually leading to inflammatory cell death.
Fan, Yang, Sahana N, Bettadapura, Mark S, Smeltzer, Hua, Zhu, Shanzhi, Wang   +4 more
openaire   +2 more sources

Pyroptosis in diabetic nephropathy

Clinica Chimica Acta, 2021
Diabetic nephropathy (DN), a sterile inflammatory disease, is a serious complication of diabetes mellitus. However, recent evidence indicates that pyroptosis, a new term for pro-inflammatory cell death featured by gasdermin D (GSDMD)-stimulated plasma membrane pore generation, cell expansion and rapid lysis with the extensive secretion of pro ...
Md. Abdul Aziz, Fahad Munir, Abdullah Al Mamun, Yanqing Wu, Muhammad Zaeem, Suzia Aktar Suchi, Eman Alyafeai, Anjuman Ara Mimi, Jian Xiao   +8 more
openaire   +3 more sources

Gasdermins and pyroptosis in the kidney

Nature Reviews Nephrology, 2023
Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1- and inflammasome-dependent cell death pathway typified by the loss of membrane integrity and the secretion of cytokines such as IL-1β.
Esteban E. Elias, Brayden Lyons, Daniel A. Muruve   +2 more
openaire   +2 more sources

Molecular Mechanisms of Pyroptosis

2023
Pyroptosis is a regulated form of cell death that leads to inflammation and plays a role in many different diseases. Pyroptosis was initially defined by the dependence on caspase-1, a protease which is activated by innate immune signaling complexes called inflammasomes.
Marisa J, Anderson, Andreas B, den Hartigh, Susan L, Fink   +2 more
openaire   +2 more sources

New prospects of cancer therapy based on pyroptosis and pyroptosis inducers

Apoptosis, 2023
Pyroptosis is a gasdermin-mediated programmed cell death (PCD) pathway. It differs from apoptosis because of the secretion of inflammatory molecules. Pyroptosis is closely associated with various malignant tumors. Recent studies have demonstrated that pyroptosis can either inhibit or promote the development of malignant tumors, depending on the cell ...
Qiaoyun, Chen, Yuxiang, Sun, Siliang, Wang, Jingyan, Xu   +3 more
openaire   +2 more sources

A checkpoint for pyroptosis

Science Signaling, 2020
The nuclear pool of an immune checkpoint protein promotes pyroptosis and tumor necrosis downstream of TNFα.
openaire   +2 more sources