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Gasdermins: Effectors of Pyroptosis [PDF]

Trends in Cell Biology, 2017
Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase-11/4/5, which cleave gasdermin D, separating its N-terminal pore-forming domain (PFD) from the C-terminal repressor domain (RD).
Edward Miao
exaly   +3 more sources

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Pyroptosis in diabetic nephropathy

Clinica Chimica Acta, 2021
Diabetic nephropathy (DN), a sterile inflammatory disease, is a serious complication of diabetes mellitus. However, recent evidence indicates that pyroptosis, a new term for pro-inflammatory cell death featured by gasdermin D (GSDMD)-stimulated plasma membrane pore generation, cell expansion and rapid lysis with the extensive secretion of pro ...
Abdullah, Al Mamun, Anjuman, Ara Mimi, Yanqing, Wu, Muhammad, Zaeem, Md, Abdul Aziz, Suzia, Aktar Suchi, Eman, Alyafeai, Fahad, Munir, Jian, Xiao   +8 more
openaire   +2 more sources

Gasdermins and pyroptosis in the kidney

Nature Reviews Nephrology, 2023
Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1- and inflammasome-dependent cell death pathway typified by the loss of membrane integrity and the secretion of cytokines such as IL-1β.
Esteban E. Elias, Brayden Lyons, Daniel A. Muruve   +2 more
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PYROPTOSIS and THE MECHANISM OF PYROPTOSIS

2023
Hücresel inflamatuar nekrozolarak da bilinen piroptoz, programlanmış hücre ölümünün yeni bir şeklidir. İlkolarak 1992'de Gram negatif bakterilerle enfekte olmuş makrofajlarda tanımlananpiroptozis daha sonra çeşitli bağışıklık hücrelerinde de bildirilmiştir.
Gezer, Arzu, Karadağ Sarı, Ebru
openaire   +1 more source

New prospects of cancer therapy based on pyroptosis and pyroptosis inducers

Apoptosis, 2023
Pyroptosis is a gasdermin-mediated programmed cell death (PCD) pathway. It differs from apoptosis because of the secretion of inflammatory molecules. Pyroptosis is closely associated with various malignant tumors. Recent studies have demonstrated that pyroptosis can either inhibit or promote the development of malignant tumors, depending on the cell ...
Qiaoyun, Chen, Yuxiang, Sun, Siliang, Wang, Jingyan, Xu   +3 more
openaire   +2 more sources

Molecular Mechanisms of Pyroptosis

2023
Pyroptosis is a regulated form of cell death that leads to inflammation and plays a role in many different diseases. Pyroptosis was initially defined by the dependence on caspase-1, a protease which is activated by innate immune signaling complexes called inflammasomes.
Marisa J, Anderson, Andreas B, den Hartigh, Susan L, Fink   +2 more
openaire   +2 more sources

Bioorthogonal Disruption of Pyroptosis Checkpoint for High-Efficiency Pyroptosis Cancer Therapy

Journal of the American Chemical Society, 2023
Pyroptosis is an inflammatory form of programmed cell death that holds great promise in cancer therapy. However, autophagy as the crucial pyroptosis checkpoint and the self-protective mechanism of cancer cells significantly weakens the therapeutic efficiency. Here, a bioorthogonal pyroptosis nanoregulator is constructed to induce pyroptosis and disrupt
Wenting Zhang, Zhengwei Liu, Jiawei Zhu, Zhenqi Liu, Yu Zhang, Geng Qin, Jinsong Ren, Xiaogang Qu   +7 more
openaire   +2 more sources

Epithelial Pyroptosis in Host Defense

Journal of Molecular Biology, 2022
Pyroptosis is a lytic form of cell death that is executed by a family of pore-forming proteins called gasdermins (GSDMs). GSDMs are activated upon proteolysis by host proteases including the proinflammatory caspases downstream of inflammasome activation.
Madeline J. Churchill, Patrick S. Mitchell, Isabella Rauch   +2 more
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Role of gasotransmitters in pyroptosis

International Journal of Biological Macromolecules
Pyroptosis is a special form of programmed cell death. Pyroptosis is triggered by inflammasomes. The main morphological change is that the cells continue to expand until the cell membrane ruptures, and then the cell contents are released, triggering a strong inflammatory response.
Hong-Jie, Li, Meng-Yuan, Hao, Hang-Shen, Han, Ti, Chu, Yan-Wen, Wang, Wei-Rong, Si, Qi-Ying, Jiang, Dong-Dong, Wu   +7 more
openaire   +2 more sources

Ferroptosis and Pyroptosis in Epilepsy

Molecular Neurobiology
Epilepsy is sudden, recurrent, and transient central nervous system dysfunction caused by abnormal discharge of neurons in the brain. Ferroptosis and pyroptosis are newly discovered ways of programmed cell death. One of the characteristics of ferroptosis is the oxidative stress generated by lipid peroxides.
Fan Feng, Rong Luo, Dezhi Mu, Qianyun Cai   +3 more
openaire   +2 more sources