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Role of pyroptosis in liver diseases
International Immunopharmacology, 2020Pyroptosis is known as a novel form of pro-inflammatory cell death program, which is exceptional from other types of cell death programs. Particularly, pyroptosis is characterized by Gasdermin family-mediated pore formation and subsequently cellular lysis, also release of several pro-inflammatory intracellular cytokines.
Kasfia Jahan Sathy +8 more
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Coral gasdermin triggers pyroptosis
Science Immunology, 2020Coral gasdermin is activated by caspase 3 and involved in pathogen-induced coral death.
Shuai Jiang +4 more
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Ferroptosis and Pyroptosis in Epilepsy
Molecular NeurobiologyEpilepsy is sudden, recurrent, and transient central nervous system dysfunction caused by abnormal discharge of neurons in the brain. Ferroptosis and pyroptosis are newly discovered ways of programmed cell death. One of the characteristics of ferroptosis is the oxidative stress generated by lipid peroxides.
Fan Feng +3 more
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Destroying tumors with pyroptosis
Science Signaling, 2020Gasdermin E suppresses tumor growth by stimulating antitumor immunity in a pyroptosis-dependent manner.
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Pyroptosis heats tumour immunity
Nature Reviews Immunology, 2020Two studies published in Nature report that gasdermin-mediated pyroptosis of tumour cells induces cytotoxic lymphocyte-mediated antitumour immune responses.
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Inflammasome-independent pyroptosis
Current Opinion in ImmunologyGasdermins are membrane pore-forming proteins that cause pyroptosis, an inflammatory cell death in which cells burst and release cytokines, chemokines, and other host alarm signals, such as ATP and HMGB1, which recruit and activate immune cells at sites of infection and danger. There are five gasdermins in humans - gasdermins A to E.
Xing, Liu, Judy, Lieberman
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Science, 2020
Immunometabolism A form of inflammatory cell death called pyroptosis depends on the caspase-mediated cleavage of gasdermin D (GSDMD), the fragments of which assemble into permeability pores that then kill the cell. The mechanisms regulating this important cellular process are not yet fully understood. Humphries et al.
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Immunometabolism A form of inflammatory cell death called pyroptosis depends on the caspase-mediated cleavage of gasdermin D (GSDMD), the fragments of which assemble into permeability pores that then kill the cell. The mechanisms regulating this important cellular process are not yet fully understood. Humphries et al.
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Pyroptosis in health and disease
American Journal of Physiology-Cell PhysiologyThe field of cell death has witnessed significant advancements since the initial discovery of apoptosis in the 1970s. This review delves into the intricacies of pyroptosis, a more recently identified form of regulated, lytic cell death, and explores the roles of pyroptotic effector molecules, with a strong emphasis on their mechanisms and relevance in
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Nature Immunology, 2021 PYROPTOSIS and THE MECHANISM OF PYROPTOSIS
2023Hücresel inflamatuar nekrozolarak da bilinen piroptoz, programlanmış hücre ölümünün yeni bir şeklidir. İlkolarak 1992'de Gram negatif bakterilerle enfekte olmuş makrofajlarda tanımlananpiroptozis daha sonra çeşitli bağışıklık hücrelerinde de bildirilmiştir.
Gezer, Arzu, Karadağ Sarı, Ebru
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