Results 301 to 310 of about 77,046 (386)

PSMD14/E2F1 Axis‐Mediated CENPF Promotes the Metastasis of Triple‐Negative Breast Cancer Through Inhibiting Ferroptosis

Cancer Science, EarlyView.
PSMD14/E2F1 axis‐mediated CENPF could promote the metastasis of BC through inhibiting arachidonic acid metabolism‐induced ferroptosis. This research might bring novel insights on discovering methods in alleviating tumor metastasis in BC. ABSTRACT The metastasis of triple‐negative breast cancer (TNBC) usually contributes to the failure of treatment ...
Meifeng Zhou, Xianglu Li, Weifeng Wang, Jianyong Wu, Jindian Tan   +4 more
wiley   +1 more source

Pyroptosis drives tumor progression and immune evasion in Hepatocellular Carcinoma: a single-cell and spatial transcriptomic study. [PDF]

Discov Oncol
Tao S, Yang Y.
europepmc   +1 more source

miR-590-3pInhibits Pyroptosis in Diabetic Retinopathy by TargetingNLRP1and Inactivating the NOX4 Signaling Pathway

, 2019
Chufeng Gu, Deji Draga, Chuandi Zhou, Tong Su, Chen Zou, Qing Gu, Tashi Lahm, Zhi Zheng, Qinghua Qiu   +8 more
openalex   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Vagus nerve stimulation: a promising strategy to combat pyroptosis and inflammation in traumatic brain injury through the OX-A/NLRP3/caspase-1/GSDMD signaling pathway. [PDF]

Eur J Med Res
Kang J, Ren B, Wang J, Tang Y, Dong X.
europepmc   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition. [PDF]

Front Pharmacol
Zhang Y, Wu Q, Pan Y, Xin M, Wang W, Zhai X, Zhou P, Zhang C, Wang Y.   +8 more
europepmc   +1 more source

Dead or alive: how the immune system detects microbial viability

, 2019
Sander, L., Ugolini, M.
core   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

Oleic acid restores the impaired antitumor immunity of γδ-T cells induced by palmitic acid. [PDF]

Signal Transduct Target Ther
Zhang Y, Xiang Z, Xu Y, Cheung LS, Wang X, Wang M, Wong HHW, Zhu Z, Zhang W, Gao Y, Luo X, Cheuk YC, Zhou Y, Zha X, Chen Y, Li M, Luo F, Chu Y, Lau YL, Liu Y, Tu W.   +20 more
europepmc   +1 more source