Results 151 to 160 of about 17,074 (296)

Pharmaceuticals Made with Hydrogen: A Sustainable and Efficient Approach Using Flow Synthesis

Chemistry – A European Journal, EarlyView.
We demonstrate a sustainable strategy for pharmaceutical manufacturing by combining hydrogen, heterogeneous catalysis, and continuous flow synthesis. The development of novel catalysts and their application in a multi‐step synthesis of donepezil enabled a highly productive process with no intermediate purification.
Shū Kobayashi, Haruro Ishitani
wiley   +1 more source

Probing the Influence of Sulfur–Aromatic Interactions on the Electronic Structure of Gas‐Phase Peptides

Chemistry – A European Journal, EarlyView.
Just as fingerprints reveal identity, spectroscopic fingerprints reveal molecular secrets. In this article, we show parts of the unique fingerprint of the sulfur–aromatic interaction. By measuring how this force alters the electronic structure of gas‐phase peptides, we provide a fundamental understanding of interactions that give insights into the ...
Laura Pille, Carlos Ortiz‐Mahecha, Bart Oostenrijk, Juliette Leroux, Marion Girod, Konstantin Hirsch, Luke MacAleese, Robert Horst Meißner, Debora Scuderi, Isaak Unger, Vicente Zamudio‐Bayer, Sadia Bari, Lucas Schwob   +12 more
wiley   +1 more source

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, EarlyView.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

<i>O</i>-Vinylhydroxylamines for <i>De Novo</i> Pyrrole Synthesis. [PDF]

J Am Chem Soc
Randolph C, Buravov O, Grimm Z, Mykhailiuk PK, Kürti L.   +4 more
europepmc   +1 more source

Sustainable Synthesis of 4,7‐Dihydro‐4,7‐ethano‐2H‐isoindoles—Key Building Blocks to Benzoporphyrins

Chemistry – A European Journal, EarlyView.
A facile and sustainable route to isoindole derivatives—key benzoporphyrin precursors—brings high‐ and low‐symmetry benzoporphyrins closer to practical application. ABSTRACT Benzoporphyrins, π extended porphyrin analogues, exhibit remarkable potential for optoelectronic and theragnostic applications, yet have remained largely confined to fundamental ...
Lampros Pascal Gazetas, Michael Ruppel, Christoph Richtzenhain, Frank Hampel, Norbert Jux, Dominik Lungerich   +5 more
wiley   +1 more source

Studies and Applications of Intramolecular (4+3) Cycloadditions of Pyrroles

, 2017
While (4+3) cycloadditions commonly proceed with furans and cyclopentadienes, the corresponding reaction with pyrroles is far less reported, since pyrroles tend to undergo Friedel-Crafts type of reactions, resulting in the restoration of aromaticity ...
He, J, Chiu, P
core  

Light‐Induced Anion Translocation to Control Helical Folding in an Artificial Communication System

Chemistry – A European Journal, EarlyView.
Anion‐induced helical folding of an oligomer is controlled indirectly and reversibly by light through anion uptake/release by a photoresponsive receptor. Thus, a light signal is processed into a chemical signal in a communication‐type three‐component supramolecular system.
Indigo M. Bekaert, Suchismita Saha, Julia Villalva, David Villarón, Maxime A. Siegler, Sander J. Wezenberg   +5 more
wiley   +1 more source

Total Syntheses of Agelamadin F and (±)‐Tauroacidin A, Enabled by NaClO2‐Mediated Coupling Reactions of Oroidin and Amines

Chemistry – A European Journal, EarlyView.
Total syntheses of agelamadin F and (±)‐tauroacidin A were achieved by sodium chlorite (NaClO2)‐mediated oxidative C─N coupling. Nine C15–N–amino acid‐substituted oroidin derivatives were successfully prepared to demonstrate the applicability and versatility of this oxidative coupling reaction.
Ryosuke Hirozumi, Yuta Kudo, Yuko Cho, Mari Yotsu‐Yamashita   +3 more
wiley   +1 more source

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, EarlyView.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

Regioselective C2-Sulfonylation of Indoles and Pyrroles via SO₂ Insertions. [PDF]

Org Lett
Bai R, Cheng WL, Peng CY, Chen YH, Wang PH, Lee CF.   +5 more
europepmc   +1 more source