Results 211 to 220 of about 18,845 (239)

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Inter-and Intramolecular (4+3) Cycloadditions With Epoxy Allylsilanes as Dienophiles. [PDF]

Chem Asian J
Teo QH, Zhou Y, Krenske EH, Chiu P.
europepmc   +1 more source

Revealing the aroma profile, aroma compounds, and nutritional quality changes of sesame oil under different pre-treatments. [PDF]

Food Chem X
Yu G, Jia X.
europepmc   +1 more source

Desulfurative modification of cysteine residues in peptides and proteins <i>via</i> the installation and photoexcitation of thieno[2,3-<i>c</i>]-pyrroles. [PDF]

Chem Sci
Chen Z, Wang W, Chen B, Chen SC, Aoken A, Wu F, Zeng G, Luo T.   +7 more
europepmc   +1 more source

Chemoselective halogenation of premarineosin A for next-generation antimalarial development.

Org Biomol Chem
Harris NR, Amin S, Curtis BJ, Teklemichael AA, Dranchak P, McBride CM, Verhey-Henke L, Warrell CJ, Dulaney WM, Oliphant EN, Inglese J, Su XZ, Sherman DH, Pereira F.   +13 more
europepmc   +1 more source

Divergent photochemical ring-replacement of isoxazoles. [PDF]

Nat Commun
Xu Y, Poletti L, Arpa EM, Roure B, Ruffoni A, Leonori D.   +5 more
europepmc   +1 more source

Scaffold hopping of furans into 3-cyanopyridines. [PDF]

Nat Commun
Kafle P, Yasuda S, Herndon D, Nilson D, Fox RC, Akhmedov NG, Sharma I.   +6 more
europepmc   +1 more source

3-Aryl-2<i>H</i>-azirines as annulation reagents in the Ni(II)-catalyzed synthesis of 1<i>H</i>-benzo[4,5]thieno[3,2-<i>b</i>]pyrroles. [PDF]

Beilstein J Org Chem
Pavlenko JI, Sakharov PA, Agafonova AV, Isadzhanyan DA, Khlebnikov AF, Novikov MS.   +5 more
europepmc   +1 more source

<i>N</i>-Aryl substituents have an influence on the photophysics of tetraaryl-pyrrolo[3,2-<i>b</i>]pyrroles.

Phys Chem Chem Phys
Petrykowski WD, Banasiewicz M, Morawski O, Kałuża Z, Barboza CA, Gryko DT.   +5 more
europepmc   +1 more source