Results 291 to 300 of about 70,546 (390)

Synthesis, in vitro biological evaluation and in silico studies of novel pyrrolidine derived thiosemicarbazones as dihydrofolate reductase inhibitors. [PDF]

RSC Adv
Aftab H, Ullah S, Khan A, Al-Rashida M, Islam T, Alshammari A, Albekairi NA, Taslimi P, Al-Harrasi A, Shafiq Z, Alghamdi S.   +10 more
europepmc   +1 more source

A New Chiral Pyrrolidine- and Pyrrolidi- noneethanols for Enantioselective Addition of Diethylzinc to Arylaldehydes

, 2003
Hiroto Nakano, Yuko Okuyama, Mayumi Igarashi, Chizuko Kabuto, Hiroshi Hongo   +4 more
openalex   +1 more source

Ultrasound‐Assisted Microcontinuous Process Facilitates the Selective Deuteration of Steroid Hormones

Journal of Labelled Compounds and Radiopharmaceuticals, Volume 68, Issue 5-6, May 2025.
Herein, we demonstrate a practical and efficient approach to synthesize 12 deuterated steroid hormones with up to 98% selectivity and 99% d‐incorporation under an ultrasound‐assisted microcontinuous process. Our protocol enables rapid, inexpensive, and sustainable gram‐scale synthesis, facilitated by the reuse of deuterated solvents via molecular ...
Dan Wang, Xin Lv, Fang Wei
wiley   +1 more source

Synthesis of Diazacyclic and Triazacyclic Small-Molecule Libraries Using Vicinal Chiral Diamines Generated from Modified Short Peptides and Their Application for Drug Discovery. [PDF]

Pharmaceuticals (Basel)
Tantak MP, Rayala R, Chaudhari P, Danta CC, Nefzi A.   +4 more
europepmc   +1 more source

Pyrrolidine dithiocarbamate up-regulates the expression of the genes encoding the catalytic and regulatory subunits of gamma-glutamylcysteine synthetase and increases intracellular glutathione levels.

, 1999
Angela C. Wild, Ríona Mulcahy
openalex  

G9a an Epigenetic Therapeutic Strategy for Neurodegenerative Conditions: From Target Discovery to Clinical Trials

Medicinal Research Reviews, Volume 45, Issue 3, Page 985-1015, May 2025.
ABSTRACT This review provides a comprehensive overview of the role of G9a/EHMT2, focusing on its structure and exploring the impact of its pharmacological and/or gene inhibition in various neurological diseases. In addition, we delve into the advancements in the design and synthesis of G9a/EHMT2 inhibitors, which hold promise not only as a treatment ...
Aina Bellver‐Sanchis, Marta Ribalta‐Vilella, Alba Irisarri, Pinky Gehlot, Bhanwar Singh Choudhary, Abhisek Jana, Vivek Kumar Vyas, Deb Ranjan Banerjee, Mercè Pallàs, Ana Guerrero, Christian Griñán‐Ferré   +10 more
wiley   +1 more source

Switching Sides: Regiochemistry and Functionalization Dictate the Photoswitching Properties of Imines. [PDF]

Angew Chem Int Ed Engl
Wu J, Kreimendahl L, Greenfield JL.
europepmc   +1 more source

Heterophyllin B: Combining Isotropic and Anisotropic NMR for the Conformational Analysis of a Natural Occurring Cyclic Peptide

Magnetic Resonance in Chemistry, Volume 63, Issue 5-6, Page 417-423, May-June 2025.
A minimal conformational ensemble of cyclic peptide heterophyllin B is presented at the density functional theory accuracy using isotropic and anisotropic NMR. ABSTRACT Heterophyllin B is a natural occurring cyclic peptide with diverse attributed bioactivities.
Anton F. Ketzel, Yang Hu, Xiao‐Lu Li, Jiaqian Li, Xinxiang Lei, Han Sun   +5 more
wiley   +1 more source

Role of Pyrrolidine dithiocarbamate in inducing odontoblastic differentiation of dental pulp stem cells. [PDF]

J Conserv Dent Endod
Bhargava K, Srinidhi SR, Mulay S, Bhonde R, Kharat A, Kheur S.   +5 more
europepmc   +1 more source

Computational Design, Synthesis, and Biological Assessment of Some Pyrrolo[3,4‐c]Pyrroles Targeting Mycobacterium Tuberculosis

ChemistrySelect, Volume 10, Issue 17, May 5, 2025.
A new set of spirooxindole‐ and spiroindenoquinoxaline‐derived pyrrolo[3,4‐c] pyrroles has been synthesized through atom‐economic one‐pot multicomponent reactions. Based on the results, compounds 4b and 5a demonstrated promising Glide scores and exhibited strong binding affinity with decaprenylphosphoryl‐β‐D‐ribofuranose oxidoreductase.
Mathiyazhagan Lavanya, Rajamanikandan Sundararaj, Kailasam Saravana Mani, Krishnakumar Balu, Mani Durai, Perwez Alam, Priya SD, Mathivanan Durai, Young Ho Ahn   +8 more
wiley   +1 more source