Results 311 to 320 of about 70,546 (390)

A Convenient Synthesis of CHF₂O-Containing Pyrrolidines and Related Compounds — Prospective Building Blocks for Drug Discovery

SynOpen
Kostiantyn Levchenko, Ivan Virstiuk, Daria Menshykova, Nazariy Pokhodylo   +3 more
doaj   +1 more source

Discovery of STX-721, a Covalent, Potent, and Highly Mutant-Selective EGFR/HER2 Exon20 Insertion Inhibitor for the Treatment of Non-Small Cell Lung Cancer. [PDF]

J Med Chem
Milgram BC, Borrelli DR, Brooijmans N, Henderson JA, Hilbert BJ, Huff MR, Ito T, Jackson EL, Jonsson P, Ladd B, O'Hearn EL, Pagliarini RA, Roberts SA, Ronseaux S, Stuart DD, Wang W, Guzman-Perez A.   +16 more
europepmc   +1 more source

Iron‐Catalyzed [2+2+2] Cycloadditions for the Construction of Aromatic and Heteroaromatic Rings

Chemistry – A European Journal, Volume 31, Issue 22, April 15, 2025.
Iron catalysis has witnessed numerous applications during the last decades. This review is focused on the developments of iron complexes for the construction of aromatic and heteroaromatic rings by [2+2+2] cycloadditions. The importance of the design of the iron coordination sphere along with the use of several co‐catalysts is discussed, as well as the
William Parisot, Mansour Haddad, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal, Guillaume Lefèvre   +4 more
wiley   +1 more source

Pyrrolidine Dithiocarbamate Ameliorates Sepsis-Associated Encephalopathy by Inhibiting Autophagy and Inflammation in the Brain. [PDF]

Neurochem Res
Lu Y, Zuo Z.
europepmc   +1 more source

Two-Step Constitutional Isomerization of Saturated Cyclic Amines Using Borane Catalysis. [PDF]

JACS Au
Amber C, Petitjean TM, Sirvinskaite G, Steele RT, Sprague B, Domack J, Small DW, Sarpong R.   +7 more
europepmc   +1 more source

Short Synthesis of Structurally Diverse N-Acylhomoserine Lactone Analogs and Discovery of Novel Quorum Quenchers Against Gram-Negative Pathogens. [PDF]

Int J Mol Sci
Porras M, Hernández D, Boto A.
europepmc   +1 more source

Discovery of intermolecular cascade annulation for dihydrobenzo[b][1,8]naphthyridine-ylidene-pyrrolidinetriones. [PDF]

Chem Sci
Luo W, Zheng X, Lin H, Fu L, Long L, Yu D, Chen Z, Yang M, Wang ZX.   +8 more
europepmc   +1 more source

The Therapeutic Potential of Spirooxindoles in Cancer: A Focus on p53-MDM2 Modulation. [PDF]

Pharmaceuticals (Basel)
Girgis AS, Zhao Y, Nkosi A, Ismail NSM, Bekheit MS, Aboshouk DR, Aziz MN, Youssef MA, Panda SS.   +8 more
europepmc   +1 more source

Glutathione Involvement in Potato Response to French Marigold Volatile Organic Compounds. [PDF]

Antioxidants (Basel)
Savić J, Nakarada Đ, Stupar S, Tubić L, Milutinović M, Mojović M, Devrnja N.   +6 more
europepmc   +1 more source

Synthesis of Novel Benzofuran Spiro-2-Pyrrolidine Derivatives via [3+2] Azomethine Ylide Cycloadditions and Their Antitumor Activity. [PDF]

Int J Mol Sci
Pan B, Wang T, Zheng L, Dong Z, Liu L, Liu X, Feng T, Zhou Y, Shi Y.   +8 more
europepmc   +1 more source