Results 271 to 280 of about 37,404 (378)

Dual ETA‐ETB receptor antagonism improves metabolic syndrome‐induced heart failure with preserved ejection fraction

Fundamental &Clinical Pharmacology, Volume 39, Issue 3, June 2025.
Abstract Background Metabolic syndrome (MetS) is a multifaceted disease associated with heart failure (HF), which affects the vascular system. The endothelin (ET) system is a key player in MetS and HF; therefore, targets for ET receptors are of therapeutic interest.
Francesca Lockwood, Marianne Lachaux, Najah Harouki, Matthieu Soulié, Lionel Nicol, Sylvanie Renet, Anaïs Dumesnil, Magali Vercauteren, Jeremy Bellien, Marc Iglarz, Vincent Richard, Paul Mulder   +11 more
wiley   +1 more source

Pd-Catalyzed [4 + 1] Annulation Strategy to Functionalized 4-Methyleneproline Derivatives. [PDF]

J Org Chem
Han J, Gao W, Harrity JPA.
europepmc   +1 more source

A pyrrolidine-based specific inhibitor of cytosolic phospholipase A2α blocks arachidonic acid release in a variety of mammalian cells

, 2001
Farideh Ghomashchi, Allison Stewart, Ying Hefner, Sasanka Ramanadham, John Turk, Christina C. Leslie, Michael H. Gelb   +6 more
openalex   +1 more source

Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors

The FEBS Journal, Volume 292, Issue 11, Page 2843-2864, June 2025.
Compounds were identified that inhibit the aspartic protease plasmepsin V from Plasmodium vivax. Further development of these compounds identified compounds, such as S‐WM48, that could inhibit both plasmepsin V and plasmepsin X but plasmepsin IX was not significantly inhibited.
Anthony N. Hodder, Brad E. Sleebs, Greg Adams, Sina Rezazadeh, Anna Ngo, Kate Jarman, Stephen Scally, Peter Czabotar, Hongwu Wang, John A. McCauley, David B. Olsen, Alan F. Cowman   +11 more
wiley   +1 more source

How eriophyid mites shape metal metabolism in leaf galls on Tilia cordata

New Phytologist, Volume 246, Issue 5, Page 2222-2242, June 2025.
Summary Metal metabolism in plant–galler interactions is largely unknown. We hypothesise that the mites manipulate metal distribution by sequestration of excessive levels and differential regulation of metalloproteins to support the main functions of gall‐nutrition, protection and microenvironment.
Filis Morina, Anđela Kuvelja, Dennis Brückner, Miloš Mojović, Đura Nakarada, Syed Nadeem Hussain Bokhari, Bojan Vujić, Gerald Falkenberg, Hendrik Küpper   +8 more
wiley   +1 more source

Revisiting the 1,3-azadiene-succinic anhydride annulation reaction for the stereocontrolled synthesis of allylic 2-oxopyrrolidines bearing up to four contiguous stereocenters. [PDF]

RSC Adv
Beng TK, Kaur J, Anosike IS, Rentfro B, Newgard S.   +4 more
europepmc   +1 more source

Diastereoselective Iodoamidation of 3-Acetoxybut-1-enylamines: Synthesis of 3-Acetoxy-4-iodo-2-(p-methoxybenzyl)pyrrolidines

, 2001
Woo Song Lee, Kyu‐Tae Chang, Ki Chang Jang, Ho-Yong Park, Young Kook Kim, Ki Hun Park   +5 more
openalex   +1 more source

Non‐Covalent Molecular Interaction Rules to Define Internal Dimer Coordinates for Quantum Mechanical Potential Energy Scans

Journal of Computational Chemistry, Volume 46, Issue 14, May 30, 2025.
A molecular interaction rules (MIR) workflow for generating potential energy scans of non‐covalent interactions between molecules in well‐defined orientations is presented. This approach allows for systematic investigation of intermolecular interactions across a wide range of functional groups and model chemistries, facilitating the optimization of ...
Suliman Sharif, Anmol Kumar, Alexander D. MacKerell Jr.   +2 more
wiley   +1 more source

Reply to Piehler et al.: Depression Symptoms in Patients with Cystic Fibrosis Fluctuate at Baseline and Improve with Elexacaftor/Tezacaftor/Ivacaftor Therapy. [PDF]

Am J Respir Crit Care Med
Duff AJA, Lee TWR.
europepmc   +1 more source

Synthesis of α-(Trifluoromethyl)pyrrolidines by Cyclization of N-Tosyl-α-(trifluoromethyl)homoallylamine Derivatives

, 2001
Itsumaro Kumadaki, Shuichi Jonoshita, Kazuyuki Sato, Masaaki Omote, Akira Ando   +4 more
openalex   +1 more source