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A Study of the Reaction of OH Radicals with N-Methyl Pyrrolidinone,N-Methyl Succinimide and N-Formyl Pyrrolidinone

Journal of Atmospheric Chemistry, 2006
A study of the oxidation mechanism of N-methyl pyrrolidinone (C5H9NO, NMP) initiated by hydroxyl radicals was made at EUPHORE at atmospheric pressure (1000 ± 10) mbar of air and ambient temperature (T = 300 ± 5 K). The main products were N-methyl succinimide (NMS) (52 ± 4)% and N-formyl pyrrolidinone (FP) (23 ± 9)%. The relative rate technique was used
Amalia Muñoz   +5 more
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Hypolipidemic Activity of Substituted 2-Pyrrolidinones in Rodents

Journal of Pharmaceutical Sciences, 1983
A series of substituted 2-pyrrolidinones was evaluated for hypolipidemic activity at 20 and 30 mg/kg/day in CF1 male mice. 4-Phenyl-5,5-dicarbethoxy-2-pyrrolidinone was the most potent compound at 30 mg/kg/day, reducing serum triglyceride levels 52% after 14 days of dosing and serum cholesterol levels 48% after 16 days of dosing.
Iris H. Hallx   +3 more
openaire   +4 more sources

Pyrrolidinone and Piperidinone Isocyanides from Isocyano Esters

European Journal of Organic Chemistry, 2014
AbstractThe alkylation of isocyano esters with 1,2‐ and 1,3‐dibromoalkanes affords bromo isocyanides. Under treatment with various amines the latter form new isocyano‐substituted lactams, which can be further used in Passerini or Ugi reactions.
Ait Sidhoum, Naïm   +3 more
openaire   +5 more sources

Aneuploidy induction in Saccharomyces cerevisiae by two solvent compounds, 1‐methyl‐2‐pyrrolidinone and 2‐pyrrolidinone

Environmental and Molecular Mutagenesis, 1988
AbstractA number of solvent compounds that were tested in Saccharomyces cerevisiae were potent inducers of aneuploidy, although they did not induce any other genetic effects. As an extention of these earlier findings, 1‐methyl‐2‐pyrrolidinone was tested and was found to induce aneuploidy.
Vernon W. Mayer   +2 more
openaire   +2 more sources

Synthesis of [4‐3H]‐2‐pyrrolidinone, [4‐3H]‐N‐methyl‐2‐pyrrolidinone and N‐[14C‐methyl]‐2‐pyrrolidinone

Journal of Labelled Compounds and Radiopharmaceuticals, 1985
AbstractAn efficient synthesis of 2‐pyrrolidinone and N‐methyl‐2‐pyrrolidinone was developed in which the compounds can be labeled with tritium at either the 3‐ and 4‐positions or the 4‐position of the lactam ring. Cyclization of [2,3‐3H]‐γ‐aminobutyric acid (GABA) yielded [3,4‐3H]‐2‐pyrrolidinone and cyclization of [3‐3H]‐GABA, prepared by acid ...
George A. Digenis   +2 more
openaire   +2 more sources

Thermodynamic investigation of surfactant aggregation in 2-pyrrolidinone

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2002
Abstract The partial molal volume (Vφ,s) of several surfactants viz. sodium dodecylsulphate (SDS) and sodium tetradecylsulfate (STS), tetraethylammonium bromide (Tea-Br), Span-80, 60, 40, 20 in 2-pyrrolidinone have been determined at concentration below 0.80 mol kg−1 at 30 and 40 °C.
Ila Joshi   +2 more
openaire   +2 more sources

An Overview on Chemistry and Biological Importance of Pyrrolidinone

Current Organic Synthesis, 2018
Background: Pyrrolidinone is a five membered heterocyclic ring that is a versatile lead compound for designing powerful bioactive agents. Pyrrolidinone nucleus is one of the most important heterocyclic compound indicating notable pharmaceutical effects.
Farideh Gouranlou   +4 more
openaire   +2 more sources

ChemInform Abstract: SPIROBIS(2‐PYRROLIDINONES). I. SYNTHESIS AND ABSOLUTE CONFIGURATION OF THREE ISOMERIC SPIROBIS(2‐PYRROLIDINONES)

Chemischer Informationsdienst, 1982
AbstractDie aus dem Diester (Ia) und einem großen Überschuß Natronlauge erhaltene Dicarbonsäure (Ib) wird in das Anhydrid (II) umgewandelt, dessen Ethanolyse zu den Estern (III) führt.
Miklós Hollósi   +3 more
openaire   +2 more sources

Studies on Pyrrolidinones. A Silylated Approach to Fused Triazoles

Synthetic Communications, 1994
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
D. Couturier   +4 more
openaire   +3 more sources

Atmospheric chemistry of 1-methyl-2-pyrrolidinone

Atmospheric Environment, 1999
Rate constants for the atmospheric reactions of 1-methyl-2-pyrrolidinone with OH radicals, NO3 radicals and O3 have been measured at 296±2 K and atmospheric pressure of air, and the products of the OH radical and NO3 radical reactions investigated. Using relative rate techniques, rate constants for the gas-phase reactions of OH and NO3 radicals with 1 ...
Sara M. Aschmann, Roger Atkinson
openaire   +2 more sources

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