Results 91 to 100 of about 253,123 (156)
Cytochrome P450-based toxicity research of Pyrrolizidine alkaloids
, 2007 Pyrrolizidine alkaloids were considered as the essential components in the toxicity of some composite plants. The previous study suggested that cytochrome P450 (CYPs)–mediated bioactivation and succedent formation of DNA adducts triggered toxicity of ...
张江伟 +5 more
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Synthesis and Biosynthesis of Pyrrolizidine Alkaloids and Analogues [PDF]
, 1990 Pyrrolizidine alkaloids are important because they have a widespread occurrence and many of the alkaloids are hepatotoxic. The work presented in this thesis is divided into three sections: (a) investigations into the synthesis of pyrrolizidine bases; (b)
Thomson, Glenn McLean
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Ecotoxicology and Environmental SafetyPyrrolizidine alkaloids (PAs) are a group of naturally occurring alkaloids widely present in plants. PAs are highly hepatotoxic and have been documented to cause many incidents of human and animal poisoning.
Yanli Zhu +6 more
doaj +1 more source
, 2012 [[abstract]]Mimosa pudica is a perennial herb, it can be used as Chinese herbal medicine in Taiwan. Mimosa pudica are collected from several towns in Taiwan.We proposed by gas chromatography mass spectrometry (GC-MS) to detect Mimosa pudica whether ...
Lai, De-Hong
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Safety profile of a special butterbur extract from in migraine prevention with emphasis on the liver
Cephalalgia Reports, 2018 Background: Butterbur supplements are available in the USA and Canada and are commonly used for treating migraines. Petadolex, a special butterbur extract from Petasites hybridus, is a natural herbal product and the only butterbur extract with proven ...
HC Diener, FG Freitag, U Danesch
doaj +1 more source
, 2011 [[abstract]]Heliotropium indicum L. (Boraginaceae) is used in folk medicine for the treatment of pneumonia, liver disease and ulcer. In the present study, we have investigated the hepatotoxic and tumorigenic pyrrolizidine alkaloids (PAs) contained in H ...
Wu, Hao-Yang
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Pyrrolizidine Alkaloids in and from the Austrian Alps
Natural Product Communications, 2015 The alkaloid content of Adenostyles alliariae and A. glabra (Asteraceae) has been evaluated. Both species contain toxic macrocyclic unsaturated pyrrolizidine alkaloids with seneciphylline as the main compound accounting for more than 90% of the alkaloid ...
Remigius Chizzola
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Food and Chemical Toxicology, 2018 Comfrey root preparations are used for the external treatment of joint distortions and myalgia, due to its analgesic and anti-inflammatory properties.
A. Trifan +8 more
semanticscholar +1 more source
, 1988 345 p.Alerts the medical and public health professions to the severe risks of morbidity and mortality posed by human consumption of plants, including cereals and herbal medicines, containing pyrrolizidine alkaloids. Citing well over 500 published studies,
World Health Organization +2 more
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Toxicity of plant extracts containing pyrrolizidine alkaloids using alternative invertebrate models
Molecular Medicine Reports, 2018 Pyrrolizidine alkaloids (PAs) are a widespread class of hepatotoxic heterocyclic organic compounds found in approximately 3% of world flora. Some PAs have been shown to have genotoxic and carcinogenic effects.
O. Șeremet +11 more
semanticscholar +1 more source