Results 81 to 90 of about 253,123 (156)

Analysis of Pyrrolizidine Alkaloids in Queensland Honey: Using Low Temperature Chromatography to Resolve Stereoisomers and Identify Botanical Sources by UHPLC-MS/MS

Toxins, 2019
Pyrrolizidine alkaloids (PAs) are a diverse group of plant secondary metabolites with known varied toxicity. Consumption of 1,2-unsaturated PAs has been linked to acute and chronic liver damage, carcinogenicity and death, in livestock and humans, making ...
N. L. Hungerford, S. Carter, S. Anuj, B. Tan, Darina Hnatko, C. Martín, E. Sharma, M. Yin, T. Nguyen, K. Melksham, M. Fletcher   +10 more
semanticscholar   +1 more source

Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance

Chemistry – A European Journal, Volume 32, Issue 19, 22 May 2026.
This review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Luigi Dolcini, Daniele Lavelli, Alberto Dal Corso, Luca Pignataro   +3 more
wiley   +1 more source

Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome

Drug Design, Development and Therapy, 2015
Hong Gao,1,* Jianqing Q Ruan,2,* Jie Chen,1 Na Li,2 Changqiang Q Ke,3 Yang Ye,3–5 Ge Lin,2,4,5 Jiyao Y Wang1,61Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2School of Biomedical ...
Gao H, Ruan JQ, Chen J, Li N, Ke CQ, Ye Y, Lin G, Wang JY   +7 more
doaj  

AlkaPlorer: A database‐driven explorer for natural alkaloids and derivatives

Journal of Integrative Plant Biology, Volume 68, Issue 5, Page 1384-1398, May 2026.
The alkaloid database AlkaPlorer integrates over 130,000 compounds across 12,250 species. By linking chemical structures with biological and evolutionary data, it reveals how these molecules evolve and function. This platform serves as a vital resource for AI‐driven discovery in plant metabolism and modern drug development. ABSTRACT Alkaloids, renowned
Jiahao Li, Tao Zeng, Hongquan Xu, Xu Kang, Minghui Liang, Ruibo Wu   +5 more
wiley   +1 more source

Concepts to reduce risk of toxification by pyrrolizidine alkaloids : studying extraction behavior of pyrrolizidine alkaloids and development of a selective adsorbing material based on molecular imprinting

, 2022
Literature research on extraction and analysis of pyrrolizidine alkaloids (PAs) in 14 PA containing medicinal plants reveal that although much is already being done, still much remains to be done.
Kopp, Thomas
core   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Pyrrolizidine Alkaloids – Natural Toxins Risk in Queensland Honey

, 2017
Pyrrolizidine alkaloids are widely distributed natural toxins and their consumption has been connected with acute and chronic liver damage, and even death, in wildlife, livestock and humans.
Fletcher, M. T., Hungerford, N. L., Martin, C. L., Sharma, E., Yin, M., Were, Stephen T., Carter, S. J., Anuj, S. R., Melksham, K. J.   +8 more
core   +2 more sources

Radioactive Tracer Feeding Experiments and Product Analysis to Determine the Biosynthetic Capability of Comfrey (Symphytum officinale) Leaves for Pyrrolizidine Alkaloids

Bio-Protocol, 2018
This protocol delivers a method to determine the biosynthetic capability of comfrey leaves for pyrrolizidine alkaloids independently from other organs like roots or flowers.The protocol applies and combines radioactive tracer experiments with standard ...
Thomas Stegemann, Lars Kruse, Dietrich Ober   +2 more
doaj   +1 more source

Tabernaemontana catharinensis: A Source of Indole Alkaloids With Potential Activity as Chemotherapeutic Agents

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT This study aimed to evaluate the antitumor activity of fractions rich in indole alkaloids extracted from the leaves of the species Tabernaemontana catharinensis. The chemical composition was analyzed using high‐resolution mass spectrometry (HRMS), which identified nine known indole alkaloids, including voacangine, voacangine hydroxyindolenine,
Ana Júlia Gomes Donada, Rafael Freitas Corá, Bianca Canci, Mariana Roesch‐Ely, Pauline Fagundes Rosales, Sidnei Moura   +5 more
wiley   +1 more source

The concerning food safety issue of pyrrolizidine alkaloids: An overview

Trends in Food Science & Technology, 2022
Natalia Casado, S. Morante-Zarcero, I. Sierra   +2 more
semanticscholar   +1 more source