Results 61 to 70 of about 79,429 (193)

Supinidine Viridiflorates from the Roots of

open access: yesNatural Product Communications, 2013
The alkaloid extract from the roots of Chromolaena pulchella provided two new pyrrolizidine alkaloids, elucidated as (-)-supinidine triviridiflorate ( 1 ) and (-)-supinidine diviridiflorate ( 2 ) based on their physical and spectroscopic properties ...
Mario A. Gómez-Hurtado   +7 more
doaj   +1 more source

Ecology and evolution of pyrazines in insects

open access: yesBiological Reviews, Volume 101, Issue 4, Page 1937-1959, August 2026.
ABSTRACT Chemical communication is the oldest and most widespread form of signalling among and within organisms. Among the many compounds involved in such communication, pyrazines – nitrogen‐containing heterocyclic molecules – are especially intriguing due to their widespread occurrence across the tree of life, from bacteria and fungi to insects and ...
Zowi Oudendijk   +2 more
wiley   +1 more source

Testing chemical defence based on pyrrolizidine alkaloids

open access: yes, 2015
Pyrrolizidine alkaloids are considered the primary defence mechanism in aposematic ithomiine butterflies and arctiid moths. Despite evidence that pyrrolizidine alkaloids are effective against some invertebrate predators, proof for a protective function ...
Cardoso, MZ
core   +1 more source

Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome

open access: yesDrug Design, Development and Therapy, 2015
Hong Gao,1,* Jianqing Q Ruan,2,* Jie Chen,1 Na Li,2 Changqiang Q Ke,3 Yang Ye,3–5 Ge Lin,2,4,5 Jiyao Y Wang1,61Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2School of Biomedical ...
Gao H   +7 more
doaj  

Inhibiting HIF‐1α‐Induced miR‐663b Improves Pulmonary Arterial Hypertension by Reducing Dysfunctions of PASMCs Through Repressing Sirt1‐ZBP1‐Mediated PANoptosis

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Pulmonary arterial hypertension (PAH) is a progressive disease characterised by vascular remodelling. Inflammatory responses and oxidative stress have been shown to contribute to its progression. This study investigated the effects of a novel HIF‐1α‐miR‐663b axis on pulmonary arterial smooth muscle inflammation, oxidative stress and apoptosis ...
Le Shen   +6 more
wiley   +1 more source

Steviol Glycosides (E960) From Stevia rebaudiana: Technological Innovations, Safety Assessment, Regulatory Aspects and Their Role in Sustainable Food Systems

open access: yesFood Science &Nutrition, Volume 14, Issue 7, July 2026.
Steviol Glycosides (E960) from Stevia rebaudiana: Technological Innovations, Safety Assessment, Regulatory Aspects and their Role in Sustainable Food Systems. ABSTRACT Stevia (Stevia rebaudiana Bertoni) is a small perennial herb widely recognized as a natural sweetener.
Aswin Sakthivel Manoharan   +1 more
wiley   +1 more source

THE PYRROLIZIDINE ALKALOIDS FROM SENECIO-RACEMOSUS

open access: yes, 1991
Two new pyrrolizidine alkaloids, racemocine and racemonine, have been isolated from Senecio racemosus.
AHMED, W   +4 more
core   +1 more source

Assessment of Liver and Kidney Safety of Silver Fir (Abies alba) Branch Extract: An Open‐Label Human Study of a Dietary Supplement

open access: yesFood Science &Nutrition, Volume 14, Issue 7, July 2026.
This study evaluated the short‐term effects of a standardized silver fir (Abies alba) branch extract (SFBE, Belinal) on biochemical markers of liver and kidney function in healthy adults. No statistically significant or clinically meaningful changes in hepatic or renal biomarkers were observed after 14 days of supplementation with 900 mg/day SFBE ...
Katja Schoss, Samo Kreft
wiley   +1 more source

Regulatory role of oxidative stress in retrorsine – Induced apoptosis and autophagy in primary rat hepatocytes

open access: yesEcotoxicology and Environmental Safety
Pyrrolizidine alkaloids (PAs) are a group of naturally occurring alkaloids widely present in plants. PAs are highly hepatotoxic and have been documented to cause many incidents of human and animal poisoning.
Yanli Zhu   +6 more
doaj   +1 more source

Radioactive Tracer Feeding Experiments and Product Analysis to Determine the Biosynthetic Capability of Comfrey (Symphytum officinale) Leaves for Pyrrolizidine Alkaloids

open access: yesBio-Protocol, 2018
This protocol delivers a method to determine the biosynthetic capability of comfrey leaves for pyrrolizidine alkaloids independently from other organs like roots or flowers.The protocol applies and combines radioactive tracer experiments with standard ...
Thomas Stegemann   +2 more
doaj   +1 more source

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