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Role of glutathione in augmenting the anticancer activity of pyrroloquinoline quinone (PQQ) [PDF]

open access: yesRedox Report, 2010
Pyrroloquinoline quinone (PQQ), a bacterial redox co-factor and antioxidant, is highly reactive with nucleophilic compounds present in biological fluids. PQQ induced apoptosis in human promonocytic leukemia U937 cells and this was accompanied by depletion of the major cellular antioxidant glutathione and increase in intracellular reactive oxygen ...
Bhavani S Shankar   +2 more
exaly   +3 more sources
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Pyrroloquinoline quinone (PQQ) prevents fibril formation of α-synuclein

Biochemical and Biophysical Research Communications, 2006
Pyrroloquinoline quinone (PQQ) is a noncovalently bound cofactor in the bacterial oxidative metabolism of alcohols. PQQ also exists in plants and animals. Due to its inherent chemical feature, namely its free-radical scavenging properties, PQQ has been drawing attention from both the nutritional and the pharmacological viewpoint.
Masaki Kobayashi   +2 more
exaly   +3 more sources

Oxidation of polyamines by pyrroloquinoline quinone (PQQ)

Tetrahedron, 1989
Abstract Pyrroloquinoline quinone (PQQ) was found to oxidize the polyamines spermine and spermidine in stoichiometric amounts with diaminopropane as the main product identified by reversed phase high performance liquid chromatography and mass spectroscopy of the reaction products.
G. Houen, C. Larsen, L.-I. Larsson
openaire   +1 more source

Synthesis and crystal structure of pyrroloquinoline quinol (PQQH2) and pyrroloquinoline quinone (PQQ)

Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, 2017
Pyrroloquinoline quinone (PQQ) is a water-soluble quinone compound first identified as a cofactor of alcohol- and glucose-dehydrogenases (ADH and GDH) in bacteria. For example, in the process of ADH reaction, alcohol is oxidized to the corresponding aldehyde, and inversely PQQ is reduced to pyrroloquinoline quinol (PQQH2).
Kazuto, Ikemoto   +2 more
openaire   +2 more sources

Genotoxicity of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ™)

Regulatory Toxicology and Pharmacology, 2013
The genotoxic potential of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ™) was evaluated in a battery of genotoxicity tests. The results of the bacterial mutation assay (Ames test) were negative. Weak positive results were obtained in 2 separate in vitro chromosomal aberration test in Chinese hamster lung (CHL) fibroblasts. Upon testing in an in
Masahiko, Nakano   +4 more
openaire   +2 more sources

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