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Neuroprotective role of pyrroloquinoline quinone in folate deficiency-induced blood-brain barrier disruption. [PDF]
Aboulhassane S +3 more
europepmc +1 more source
Role of glutathione in augmenting the anticancer activity of pyrroloquinoline quinone (PQQ) [PDF]
Pyrroloquinoline quinone (PQQ), a bacterial redox co-factor and antioxidant, is highly reactive with nucleophilic compounds present in biological fluids. PQQ induced apoptosis in human promonocytic leukemia U937 cells and this was accompanied by depletion of the major cellular antioxidant glutathione and increase in intracellular reactive oxygen ...
Bhavani S Shankar +2 more
exaly +3 more sources
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Pyrroloquinoline quinone (PQQ) prevents fibril formation of α-synuclein
Biochemical and Biophysical Research Communications, 2006Pyrroloquinoline quinone (PQQ) is a noncovalently bound cofactor in the bacterial oxidative metabolism of alcohols. PQQ also exists in plants and animals. Due to its inherent chemical feature, namely its free-radical scavenging properties, PQQ has been drawing attention from both the nutritional and the pharmacological viewpoint.
Masaki Kobayashi +2 more
exaly +3 more sources
Oxidation of polyamines by pyrroloquinoline quinone (PQQ)
Tetrahedron, 1989Abstract Pyrroloquinoline quinone (PQQ) was found to oxidize the polyamines spermine and spermidine in stoichiometric amounts with diaminopropane as the main product identified by reversed phase high performance liquid chromatography and mass spectroscopy of the reaction products.
G. Houen, C. Larsen, L.-I. Larsson
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Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, 2017
Pyrroloquinoline quinone (PQQ) is a water-soluble quinone compound first identified as a cofactor of alcohol- and glucose-dehydrogenases (ADH and GDH) in bacteria. For example, in the process of ADH reaction, alcohol is oxidized to the corresponding aldehyde, and inversely PQQ is reduced to pyrroloquinoline quinol (PQQH2).
Kazuto, Ikemoto +2 more
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Pyrroloquinoline quinone (PQQ) is a water-soluble quinone compound first identified as a cofactor of alcohol- and glucose-dehydrogenases (ADH and GDH) in bacteria. For example, in the process of ADH reaction, alcohol is oxidized to the corresponding aldehyde, and inversely PQQ is reduced to pyrroloquinoline quinol (PQQH2).
Kazuto, Ikemoto +2 more
openaire +2 more sources
Genotoxicity of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ™)
Regulatory Toxicology and Pharmacology, 2013The genotoxic potential of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ™) was evaluated in a battery of genotoxicity tests. The results of the bacterial mutation assay (Ames test) were negative. Weak positive results were obtained in 2 separate in vitro chromosomal aberration test in Chinese hamster lung (CHL) fibroblasts. Upon testing in an in
Masahiko, Nakano +4 more
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