Results 121 to 130 of about 27,529 (245)

Energy metabolism, adenosine, and glutamate signaling reprogramming by decanoic acid in Glut1 disorder syndrome

Epilepsia Open, Volume 11, Issue 3, Page 1036-1045, June 2026.
Abstract Glut1 deficiency syndrome (Glut1DS) leads to neurological and cognitive symptoms and is primarily treated using carbohydrate‐restricted ketogenic diets. However, a recent clinical trial of a less restrictive, non‐ketogenic, medium chain triglyceride (MCT) diet with a high decanoic acid content suggests efficacy in Glut1DS treatment.
Erwann Pain, Yatra Kapatel, Pankaj K. Singh, Katie Lloyd Jones, Jamuna Selvakumaran, Alberto Malerba, Walter Lucchesi, Tricia Rutherford, Christina A. Gurnett, Matthew C. Walker, Robin S. B. Williams   +10 more
wiley   +1 more source

Allosteric Regulation of Pyruvate Carboxylase

, 2018
Pyruvate carboxylase (PC; E.C.6.4.1.1) is a multifunctional, biotin-dependent enzyme that catalyzes the MgATP-dependent carboxylation of pyruvate to oxaloacetate. The overall reaction is accomplished by the coupling of two half reactions occurring at two
Liu, Yumeng
core  

Interaction between the biotin carboxyl carrier domain and the biotin carboxylase domain in pyruvate carboxylase from rhizobium etli

, 2010
Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues.
Zeczycki, Tonya N., Wallace, John C., Adam D. Lietzan, Martin St. Maurice, Menefee, A., Maurice, M., Zeczycki, T., Ann L. Menefee, John C. Wallace, Wallace, J., Menefee, Ann L., Cleland, W., Attwood, Paul V., Lietzan, A., Sudhanshu Kumar, Cleland, W. Wallace, St. Maurice, Martin, Attwood, P., Tonya N. Zeczycki, Lietzan, Adam D., W. Wallace Cleland, Kumar, S., Paul V. Attwood, Kumar, Sudhanshu   +23 more
core   +1 more source

Nutritional Potential, Phytochemical Content, In Vivo Antioxidant, and Antanemic Potential of Musa paradisiaca Flower

Food Chemistry International, Volume 2, Issue 2, Page 246-262, June 2026.
After collecting Musa paradisiaca leaves, some were dried and others were used to produce aqueous extracts. The extracts and powders were characterized and then administered to rats made anaemic by PHZ. After 14 days of administration of the two samples, the rats were euthanized and it was observed that after 9 days of treatment, the aqueous extract ...
Josée Rebeca Nombo, Jethro Roland Misse Ngangue Ekwala, Somon Régine Tuem, Stéphano Tene Tambo, Merlin Ngafon Nchoutpouen, Valery Jean François Nsoga, Jules Christophe Koule Manz, Jordan Mekui Nwotue, Mathieu Ndomou   +8 more
wiley   +1 more source

Pyruvate carboxylase as an anaplerotic enzyme in Corynebacterium glutamicum

, 1997
Peters-Wendisch P, Wendisch VF, Paul S, Eikmanns BJ, Sahm H. Pyruvate carboxylase as an anaplerotic enzyme in Corynebacterium glutamicum. Microbiology. 1997;143(4):1095-1103.The recent discovery that phosphoenolpyruvate carboxylase (PEPCx) is dispensable
Paul, S., Eikmanns, B. J., Wendisch, Volker F. ; https://orcid.org/, Sahm, H., Peters-Wendisch, Petra   +4 more
core   +1 more source

Effect of pyruvate carboxylase overexpression on the physiology of Corynebacterium glutamicum

, 2002
Pyruvate carboxylase was recently sequenced in Corynebacterium glutamicum and shown to play an important role of anaplerosis in the central carbon metabolism and amino acid synthesis of these bacteria.
Gregory Stephanopoulos, Gyoo Yeol Jung, Juan C. Aon, Mattheos A. G. Koffas   +3 more
core  

Synthesis and Evaluation of Small Molecule Inhibitors of Pyruvate Carboxylase

, 2020
Through structure-based drug design (SBDD), a series of small molecules have been synthesized and evaluated for inhibitory activity against the pyruvate carboxylase (PC) enzyme via two biological assays.
Burkett, Daniel John
core  

Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application

MedComm, Volume 7, Issue 6, June 2026.
The modulation of the TME by fatty acid metabolism primarily occurs through four key pathways: inflammation regulation, signal transduction, translation to TME, and oxidative stress. ABSTRACT Fatty acid metabolism (FAM) plays a vital role in maintaining health by supporting energy production, cellular structure, and signaling processes.
Na Hang, Runkang Zhao, Fan Zhang, Dandan Guo, Qing Li, Zhijun Shen, Ruiqing Gao, Chenyu Gao, Zhao Xie, Sentao Fu, Peng Luo, Bufu Tang, Ling Wang   +12 more
wiley   +1 more source

Pyruvate Carboxylase

Journal of Biological Chemistry, 1973
Michael C. Scrutton, M. Dawn White
openaire   +1 more source

Novel Insights into the Biotin Carboxylase Domain Reactions of Pyruvate Carboxylase from Rhizobium etli

, 2016
The catalytic mechanism of the MgATP-dependent carboxylation of biotin in the biotin carboxylase domain of pyruvate carboxylase from R. etli (RePC) is common to the biotin-dependent carboxylases.
Paul V. Attwood (2034118), Tonya N. Zeczycki (2034115), Martin St. Maurice (1606501), W. Wallace Cleland (2034109), Sarawut Jitrapakdee (286278), John C. Wallace (194800), Ann L. Menefee (2147278), Abdussalam Adina-Zada (503883), Kathy H. Surinya (2147290)   +8 more
core   +1 more source