Results 111 to 120 of about 27,529 (245)

Pyruvate carboxylase from Corynebacterium glutamicum : purification and characterization

, 2020
Pyruvate carboxylase of Corynebacterium glutamicum serves as anaplerotic enzyme when cells are growing on carbohydrates and plays an important role in the industrial production of metabolites derived from the tricarboxylic acid cycle, such as l-glutamate
Baumgart, Meike, Bott, Michael, Kortmann, Maike   +2 more
core   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Holocarboxylase Synthetase 1 Physically Interacts with Histone H3 in Arabidopsis

Scientifica, 2013
Biotin is a water-soluble vitamin required by all organisms, but only synthesized by plants and some bacterial and fungal species. As a cofactor, biotin is responsible for carbon dioxide transfer in all biotin-dependent carboxylases, including acetyl-CoA
Xi Chen, Hui-Hsien Chou, Eve Syrkin Wurtele   +2 more
doaj   +1 more source

Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Simply constructed polyvinylpyrrolidone (PVP) modified palladium nanoparticles (PdP NPs) as cytochrome c oxidase (CcO) and superoxide dismutase (SOD) mimic are promising multifunctional nanoreactors to boost mitochondrial respiration chain function and refine homeostasis via regulation of mitochondrial dynamics and proteostasis sensor UPRmt, which ...
Wenshu Cong, Haiming Jing, Zinan Li, Wenjing Zhang, Nan Zhang, Yingqiu Xie, Shan Gao, Yuanyu Huang, Junyu Ning   +8 more
wiley   +1 more source

Activation and Inhibition of Pyruvate Carboxylase from Rhizobium etli

, 2016
While crystallographic structures of the R. etli pyruvate carboxylase (PC) holoenzyme revealed the location and probable positioning of the essential activator, Mg2+, and nonessential activator, acetyl-CoA, an understanding of how they affect catalysis ...
Paul V. Attwood (2034118), Tonya N. Zeczycki (2034115), Martin St. Maurice (1606501), W. Wallace Cleland (2034109), Sarawut Jitrapakdee (286278), John C. Wallace (194800), Ann L. Menefee (2147278)   +6 more
core   +1 more source

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1192-1203, June 2026.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

Pyruvate Carboxylase

Journal of Biological Chemistry, 1965
Michael C. Scrutton, Merton F. Utter
openaire   +2 more sources

Interaction between the Biotin Carboxyl Carrier Domain and the Biotin Carboxylase Domain in Pyruvate Carboxylase from Rhizobium etli

, 2016
Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues.
Paul V. Attwood (2034118), Martin St. Maurice (1606501), W. Wallace Cleland (2034109), John C. Wallace (194800), Adam D. Lietzan (2113714), Tonya N. Zeczycki (1752880), Sudhanshu Kumar (333563), Ann L. Menefee (2147278)   +7 more
core   +1 more source

Advancing Malic Acid Production of Aspergillus oryzae: Combined Process Optimization and Application of Various Substrates

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1634-1647, June 2026.
ABSTRACT In light of climate change and growing resource scarcity, microbial production of organic acids offers a sustainable alternative to fossil‐based chemical synthesis. In this study, malic acid production by Aspergillus oryzae was optimized through cultivation temperature adjustment and biotin supplementation, while organic acid formation from ...
Lukas Hartmann, Anke Neumann, Dirk Holtmann, Björn Vater, Thomas Hahn, Susanne Zibek, Katrin Ochsenreither   +6 more
wiley   +1 more source

Novel insights into the biotin carboxylase domain reactions of pyruvate carboxylase from Rhizobium etli

, 2011
The catalytic mechanism of the MgATP-dependent carboxylation of biotin in the biotin carboxylase domain of pyruvate carboxylase from R. etli (RePC) is common to the biotin-dependent carboxylases.
Menefee, A., Sarawut Jitrapakdee, Zeczycki, Tonya N, John C. Wallace, Surinya, K., Wallace, J., Jitrapakdee, Sarawut, Abdussalam Adina-Zada, Surinya, Kathy H, Cleland, W., Maurice, Martin St., Kathy H. Surinya, Adina-Zada, Abdussalam, Attwood, P., W. Wallace Cleland, Jitrapakdee, S., Martin St. Maurice, Maurice, M., Zeczycki, T., Ann L. Menefee, Menefee, Ann L, Adina-Zada, A., Cleland, W Wallace, Wallace, John C, Attwood, Paul V, Tonya N. Zeczycki, Paul V. Attwood   +26 more
core   +1 more source