Results 91 to 100 of about 27,529 (245)

Pyruvate carboxylase is expressed in human skeletal muscle

, 2010
Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyses the carboxylation of pyruvate to oxaloacetate thereby allowing supplementation of citric acid cycle intermediates. The presence of PC in skeletal muscle is controversial.
Ariane D. Minet, Minet, Ariane D, Michael Gaster, Gaster, Michael   +3 more
core   +1 more source

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

Improvement of succinate production from methane by combining rational engineering and laboratory evolution in Methylomonas sp. DH-1

Microbial Cell Factories
Recently, methane has been considered a next-generation carbon feedstock due to its abundance and it is main component of shale gas and biogas. Methylomonas sp. DH-1 has been evaluated as a promising industrial bio-catalyst candidate.
Jae-Hwan Jo, Jeong-Ho Park, Byung Kwon Kim, Seon Jeong Kim, Chan Mi Park, Chang Keun Kang, Yong Jun Choi, Hyejin Kim, Eun Yeol Lee, Myounghoon Moon, Gwon Woo Park, Sangmin Lee, Soo Youn Lee, Jin-Suk Lee, Won-Heong Lee, Jeong-Il Kim, Min-Sik Kim   +16 more
doaj   +1 more source

Excessive training does not induce mitochondrial dysfunction or impair insulin signalling within skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Three weeks of overtraining in trained endurance athletes reduced exercise performance without impairing glucose tolerance. In skeletal muscle, overtraining was associated with increased expression of lipid metabolism‐related proteins, enhanced mitochondrial biogenesis and preserved insulin signalling, despite elevated oxidative ...
Geneviève J. DesOrmeaux, Henver S. Brunetta, Pierre‐Andre Barbeau, Alexandra M. Coates, Christopher Pignanelli, Fasih A. Rahman, Jamie F. Burr, Graham P. Holloway   +7 more
wiley   +1 more source

Expression of PEP carboxylase from Escherichia coli complements the phenotypic effects of pyruvate carboxylase mutations in Saccharomyces cerevisiae

, 1997
We investigated the effects of the expression of the Escherichia coli ppc gene encoding PEP carboxylase in Saccharomyces cerevisiae mutants devoid of pyruvate carboxylase. Functional expression of the ppc gene restored the ability of the yeast mutants to
Flores, Carmen-Lisset, Gancedo, Carlos, Carmen-Lisset Flores, Carlos Gancedo   +3 more
core   +1 more source

Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos, Martin Olmos, Courtney P. Wood, Camila Alvarez, Haley M. Read, Parima Udompholkul, Theodore Garland Jr, Nicholas V. DiPatrizio   +7 more
wiley   +1 more source

Rat liver pyruvate carboxylase. Purification, detection and quantification of apo and holo forms by immuno-blotting and by an enzyme-linked immunosorbent assay [PDF]

, 1986
A simple scheme for the purification of pyruvate carboxylase from rat liver mitochondria is described. It is rapid and provides high-purity pyruvate carboxylase with excellent yield and reproducibility.
Ahmad, F, Ahmad, P M, Mendez, A
core   +1 more source

Hyperpolarized MRI Detects Increased [1‐13C]Pyruvate Metabolism in Early Liver Regeneration

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
Hyperpolarized [1‐13C]pyruvate MRI detected increased pyruvate‐to‐lactate and pyruvate‐to‐alanine exchange during early liver regeneration following 70% partial hepatectomy in rats. These findings support the use of hyperpolarized MRI for noninvasive assessment of regenerative metabolism.
Uffe Kjærgaard, Andrea Lund, Lotte Bonde Bertelsen, Esben Søvsø Szocska Hansen, Katrine Holm Andersen, Steffen Ringgaard, Jens Randel Nyengaard, Frank Viborg Mortensen, Christoffer Laustsen   +8 more
wiley   +1 more source

Activation and inhibition of pyruvate carboxylase from Rhizobium etli

, 2011
While crystallographic structures of the R. etli pyruvate carboxylase (PC) holoenzyme revealed the location and probable positioning of the essential activator, Mg(2+), and nonessential activator, acetyl-CoA, an understanding of how they affect catalysis
Martin St. Maurice, Menefee, A., Sarawut Jitrapakdee, Maurice, M., Zeczycki, T., Ann L. Menefee, Zeczycki, Tonya N, Menefee, Ann L, John C. Wallace, Cleland, W Wallace, Wallace, J., Wallace, John C, Jitrapakdee, Sarawut, Cleland, W., Attwood, Paul V, St. Maurice, Martin, Attwood, P., Tonya N. Zeczycki, W. Wallace Cleland, Jitrapakdee, S., Paul V. Attwood   +20 more
core   +1 more source

Multiple Carboxylase Deficiency in an Infant Presenting With Severe Metabolic Acidosis and Sepsis‐Like Features: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Multiple carboxylase deficiency (MCD) is a rare, treatable inborn error of biotin metabolism that may present in children in the first year of life with life‐threatening metabolic crises. We report a 4‐month‐old child presenting with persistent seizures, eczematous rash near the orifices, unjustified loss of hair with baldness, and severe ...
Touqeer Rehman, Riyan Saeed, Muhammad Ahmed Akif Rauf, Luqman Asif, Muhammad Junaid, Muddassir Khalid, Rao Nouman Ali, Umair Ali, Fred Segawa   +8 more
wiley   +1 more source