Results 81 to 90 of about 27,301 (195)

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Multiplexed Nanosensors for Real‐Time Monitoring of VOC‐Mediated Signalling Response in Plants

Plant, Cell &Environment, Volume 49, Issue 12, Page 9907-9931, December 2026.
ABSTRACT To enhance crop performance, intercropping strategies leverage volatile organic compound (VOC)‐driven interactions with companion plants that constitutively emit VOCs. Despite the agricultural importance, the mechanisms and kinetics of VOC‐mediated sensory transduction in receiver plants eavesdropping on neighbouring non‐kin emitters remain ...
Mervin Chun‐Yi Ang, Jolly Madathiparambil Saju, Sayyid Mohaideen, Niha Dhar, Sarangapani Sreelatha, Sayuj Koyyappurath, Thomas K. Porter, Gabriel Sánchez‐Velázquez, Vaishnavi Reddy Amarr, Song Wang, Duc Thinh Khong, Suh In Loh, Michael S. Strano, Sarojam Rajani   +13 more
wiley   +1 more source

Mitochondrial Respiratory Metabolism in Salt‐Stressed Barley (Hordeum vulgare): TCA Cycle Activation With Limited GABA Shunt Engagement

Plant, Cell &Environment, Volume 49, Issue 12, Page 10042-10060, December 2026.
ABSTRACT Plants maintain energy balance under salinity stress through increased respiration and energy use, processes also associated with reactive oxygen species generation. Although respiration imposes a high energy cost, mitochondrial respiration and the tricarboxylic acid (TCA) cycle activity are vital for ATP production and for providing electron ...
Ali Bandehagh, Nicolas L. Taylor
wiley   +1 more source

Short‐Term Unacylated Ghrelin Administration Improves Pyruvate Tolerance Without Chronically Altering Skeletal Muscle, Liver, or Adipose Tissue Insulin Response in Healthy Rats

The FASEB Journal, Volume 40, Issue 21, 15 November 2026.
Unacylated ghrelin (unAG) has been previously shown to acutely increase fatty acid oxidation (FAO) in skeletal muscle. 5 days of unAG administration to healthy male rats improved pyruvate tolerance, however this was not associated with changes in hepatic glucose‐production associated proteins.
Nicole M. Notaro, Sofia F. Prizio, Brielle R. Caruso, David J. Dyck   +3 more
wiley   +1 more source

A Case of Multiple Mitochondrial Dysfunctions Syndrome 1 and Review of the Literature

American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2409-2419, November 2026.
ABSTRACT Multiple mitochondrial dysfunctions syndrome 1 (MMDS1, MIM #605711) due to NFU1 gene defects is an ultra‐rare autosomal recessive inborn error of metabolism associated with reduced function of NFU1 iron–sulfur cluster (ISC) scaffold protein.
Charles R. DiFalco, Aaron Williams, Claudia Soler‐Alfonso, Emily Waskow, Elizabeth Mizerik, Fernando Scaglia, Chaya N. Murali   +6 more
wiley   +1 more source

Gene‐Guided Therapy in Type 2 Diabetes Mellitus: An Integrative Review of the Pharmacogenetics of Metformin and Sodium‐Glucose Cotransporter‐2 Inhibitors

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Genetic variation influences the pharmacological response to metformin and SGLT2 inhibitors in patients with type 2 diabetes mellitus. Pharmacogenetic biomarkers affecting drug transport, metabolism and target activity contribute to inter‐individual differences in treatment efficacy and adverse effects, supporting the implementation of personalized ...
Imran Hossain, Mahnoor Haidar, Mahfuj Ahmed Ratul, Jannatul Ferdous Sumona, Sraboni Shabnaz, Abul Fojal Nokib, Fatema‐Tuz‐Zohora   +6 more
wiley   +1 more source

Novel NaV1.6‐Mitochondrial Complexes in Retinal Astrocyte Pockets Sequester GABA

Glia, Volume 74, Issue 11, November 2026.
NaV1.6 localizes in retinal astrocytes' high density pockets on the bilayer facing the ganglion cell layer. NaV colocalizes with large, anaplerotic mitochondria. These microdomains accumulate high levels of GABA. ABSTRACT Voltage‐gated sodium channels are best known for their capacity to generate and propagate electrical currents in neurons and muscle.
Joseph Matthew Holden, David John Calkins   +1 more
wiley   +1 more source

Pyruvate Carboxylase

Journal of Biological Chemistry, 1965
Michael C. Scrutton, Merton F. Utter
openaire   +2 more sources

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Unravelling the Chemolithoautotrophic Metabolism of the Carboxydotrophic Knallgas Bacterium Hydrogenophaga pseudoflava

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
Proteomics of the aerobic carboxydotroph Hydrogenophaga pseudoflava across trophic conditions revealed that an unphysiological CO concentration causes a redox imbalance and stress response. CO dehydrogenase I and the membrane‐bound hydrogenase were essential for CO and H2 oxidation, respectively, whereas the soluble hydrogenase likely supports redox ...
Simon Grieshaber, Antonia Ebert, Pauline Kehr, Dominik L. Siebert, Ammar Al‐Shameri, Volker Sieber, Birgitta E. Ebert, Esteban Marcellin, Bastian Blombach   +8 more
wiley   +1 more source