Results 71 to 80 of about 27,529 (245)

Metabolic responses to pyruvate kinase deletion in lysine producing Corynebacterium glutamicum

Microbial Cell Factories, 2008
Background Pyruvate kinase is an important element in flux control of the intermediate metabolism. It catalyzes the irreversible conversion of phosphoenolpyruvate into pyruvate and is under allosteric control.
Wittmann Christoph, Klopprogge Corinna, Becker Judith   +2 more
doaj   +1 more source

Distribution of pyruvate carboxylase along the rat nephron: An immunological and enzymatic study

, 1991
Distribution of pyruvate carboxylase along the rat nephron: An immunological and enzymatic study. Antibodies against purified rat-kidney-cortex pyruvate carboxylase were raised in rabbits.
Oliver, Javier, Vargas, Alberto M., Salto, Rafael, del Mar Sola, María   +3 more
core   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

A Patient With Pyruvate Carboxylase Deficiency and Nemaline Rods on Muscle Biopsy

, 2013
Nemaline rods are the pathologic hallmark of nemaline myopathy, but they have also been described as a secondary phenomenon in a variety of other disorders. Nemaline rods have not been reported in pyruvate carboxylase deficiency before. Here we present a
DURSUN, ALİ, ORHAN, DİCLEHAN, Wibrand, Flemming, Kalkanoglu-Sivri, H. Serap, TOKATLI, AYŞEGÜL, COŞKUN, TURGAY, ÖZTÜRK HİŞMİ, BURCU, Unal, Ozlem, Ostergaard, Elsebet   +8 more
core   +1 more source

Caffeylpyruvate hydrolase from the bioluminescent fungus Neonothopanus gardneri is the key recycling enzyme in the fungal bioluminescence pathway

The FEBS Journal, EarlyView.
Caffeic acid is a central metabolite in the fungal bioluminescence pathway. We identified and characterized caffeylpyruvate hydrolase from Neonothopanus gardneri (ngarCPH) and demonstrate its ability to hydrolyze fungal oxyluciferin into caffeic and pyruvic acids, confirming a complete and self‐sustained fungal bioluminescence cycle.
Caio K. Zamuner, Douglas M. M. Soares, Bianca B. Nóbrega, Etelvino J. H. Bechara, Zinaida M. Kaskova, Alexander S. Mishin, Karen S. Sarkisyan, Ilia V. Yampolsky, Cassius V. Stevani   +8 more
wiley   +1 more source

Characterization of the metabolic shift between oxidative and fermentative growth in Saccharomyces cerevisiae by comparative ¹³C flux analysis

Microbial Cell Factories, 2005
Background One of the most fascinating properties of the biotechnologically important organism Saccharomyces cerevisiae is its ability to perform simultaneous respiration and fermentation at high growth rate even under fully aerobic conditions.
Wittmann Christoph, Frick Oliver
doaj   +1 more source

The reaction mechanism of pyruvate carboxylase [PDF]

, 1977
1. The 2 ', 3 ' -dialdehyde derivative of ATP (oATP) was prepared by periodate oxidation, and on the following criteria was considered to be an affinity label of the MgATP ²⁻ binding site of sheep liver pyruvate carboxylase.
Easterbrook-Smith, Simon Barnett
core  

Geniposide regulated the expression of pyruvate carboxylase gene in INS-1 cells.

, 2013
A: Effect of treatment with 10 μM geniposide on the mRNA levels of pyruvate carboxylase gene, *, ** P < 0.05 , P < 0.01 vs the control. B: Effect of 10 μM geniposide treatment for 1 hour on the mRNA levels of pyruvate carboxylase gene in the presence of ...
Yonglan Zhang (475330), Lixia Guo (121549), Zixuan Liu (475331), Fei Yin (179978), Yanwen Wang (140487), Jianhui Liu (475329)   +5 more
core   +1 more source

The multidimensional regulation roles and mechanisms of calcium in fruit quality

Journal of Integrative Plant Biology, EarlyView.
This review explores how calcium signaling molecule integrates plant hormones, environmental cues, and developmental signals to influence external fruit traits, internal nutritional properties, and physiological disorders. ABSTRACT Calcium (Ca2+), a dual‐functional mineral that serves both as an essential structural factor and a signaling molecule ...
Fei Jiang, Siyang Gao, Mengdi Li, Zeqi Zhao, Chengwei Yang, Ji‐Hong Liu, Chunlong Li   +6 more
wiley   +1 more source

Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression

Advanced Science, 2020
Rapid metabolism differentiates cancer cells from normal cells and relies on anaplerotic pathways. However, the mechanisms of anaplerosis‐associated enzymes are rarely understood.
Qingxiang Lin, Yuan He, Xue Wang, Yong Zhang, Meichun Hu, Weikai Guo, Yundong He, Tao Zhang, Li Lai, Zhenliang Sun, Zhengfang Yi, Mingyao Liu, Yihua Chen   +12 more
doaj   +1 more source