Results 61 to 70 of about 13,166 (163)

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults. [PDF]

, 2019
Thiamine (vitamin B1) is an essential nutrient that serves as a cofactor for a number of enzymes, mostly with mitochondrial localization. Some thiamine-dependent enzymes are involved in energy metabolism and biosynthesis of nucleic acids whereas others ...
Adams, Alfadhel, Alfadhel, Alfadhel, Aljabri, Anwar, Aronson, Arts, Attwell, Baio, Banka, Barennes, Benton, Bettendorff, Bettendorff, Biesecker, Brown, Butterworth, Butterworth, Butterworth, Calhau, Carney, Chandrakumar, Chen, Cheung, Chornyy, Chugani, Colbert, Croft, Day, De Meirleir, Fattal-Valevski, Fattal-Valevski, Fleming, Forouhi, Foulon, Foulon, Fraccascia, Fraccascia, Fraser, Frustaci, Fujita, Galvin, Ganapathy, Gangolf, Ganie, Ghaleiha, Gibson, Giulivi, Gold, Greenwood, Gu, Harel, Hiffler, Hilker, Inaba, Ishaque, Israels, Jankowska-Kulawy, Junior, Kamasak, Karabatsiakis, Kelley, Kerns, Khaw, Kitamura, Kornreich, Kril, Laforenza, Leichter, Lindhurst, Liu, Lonsdale, Lonsdale, Lonsdale, Lorber, Lu, Lukienko, Luxemburger, Lương, Ma, Magos, Mahajan, Mahmood, Martel, Martin, Mayr, McLure, Mergenthaler, Mezzar, Mimouni-Bloch, Molina, Mulholland, Mulle, Muoio, Murata, Nabokina, Nabokina, Nardone, Navarro, Nikseresht, Obrenovich, Oishi, Opdenakker, Ortega Garcia, Ortigoza-Escobar, Pepersack, Perez-Duenas, Plaitakis, Prabakaran, Prohaska, Rabie, Randle, Renthal, Rindi, Rindi, Robinson, Roust, Rubio-Lopez, Said, Schaller, Scrimshaw, Sequeira Lopes da Silva, Shi, Singleton, Siu, Skjeldal, Smidt, Society, Song, Sperringer, Spiegel, Stargrove, Subramanian, Subramanian, Sweet, Tabarki, Talwar, Thomson, Thornalley, van den Brink, Vasconcelos, Vernau, Vernau, Vimokesant, Watkins, Wendel, Whitfield, Whitfield, Wierzbicki, Williams, Yang, Zhang, Zhao, Zuccoli   +154 more
core   +2 more sources

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

Isolating the effects of carbohydrate and lipid availability on exercise‐induced skeletal muscle signalling in males

The Journal of Physiology, EarlyView.
Abstract figure legend It is currently unknown whether the effects of low carbohydrate avalability on exercise‐induced skeletal muscle signalling and adaptations are due to the low carbohydrate availability per se, or the comcomittant high fatty acid availability. Comparing exercise after extended overnight fasting, with carbohydrate ingestion and with
Louise Bradshaw, Alfonso Moreno Cabañas, Bruno Spellanzon, Katie Marie Hutchins, Adam J. Collins, Jariya Buniam, Thibaux van der Stede, Joanne Mallinson, Kostas Tsintzas, Wim Derave, Jean‐Philippe Walhin, James A. Betts, Francoise Koumanov, Javier T. Gonzalez   +13 more
wiley   +1 more source

Sulfated Polysaccharides in the Hallmarks of Metabolic Syndrome: Functions and Mechanisms

Food Frontiers, Volume 7, Issue 1, January 2026.
The SPs sources are very diverse, including various fishes, sea cucumbers, seaweeds, etc. These SPs are able to improve the glucose and lipid metabolism disorders, hormonal dysregulation, oxidative stress, inflammatory response, complications, and gut homeostasis of MetS by regulating biochemical indicators related to MetS. ABSTRACT Metabolic syndrome (
Fuqiang Zhao, Chuan Li, Xin Zhang, Kexue Zhu, Chao Zhao, Deming Gong, Lulu Zhu, Yongcheng Li, Jun Cao, Shaoping Nie   +9 more
wiley   +1 more source

Does Glyphosate Acting as a Glycine Analogue Contribute To ALS? [PDF]

, 2016
 Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease involving several protein mutations in glycine-rich regions with limited treatment options.
Hadden, Michael J., Michener, Martin C., Morley, Wendy A., Seneff, Stephanie   +3 more
core   +1 more source

Spectrometry and Its Application for the Detection of RNA‐Binding Proteins: Advancements, Techniques and Challenges

Analytical Science Advances, Volume 6, Issue 2, December 2025.
ABSTRACT Spectrometry is a fascinating field of analytical science that encompasses a range of techniques used to study the interaction between electromagnetic radiation and matter. Through the measurement and analysis of various radiations, spectrometry provides valuable insights into the composition, structure and properties of different substances ...
Mina Moradi, Zahra Farjami, Mohammad Mehdi Akbarin   +2 more
wiley   +1 more source

Coronatine-insensitive 1 (COI1) mediates transcriptional responses of Arabidopsis thaliana to external potassium supply [PDF]

, 2010
The ability to adjust growth and development to the availability of mineral nutrients in the soil is an essential life skill of plants but the underlying signaling pathways are poorly understood.
Abe, Amtmann, Amtmann, Amtmann, Amtmann, Amtmann, Amtmann, Amtmann, Armengaud, Armengaud, Ashley, Balbi, Bednarek, Bolstad, Breitling, Breitling, Cao, Chung, Creelman, Devoto, Devoto, Dobermann, Epstein, Evans, Geisler, He, Hull, Jung, Kafkafi, Kim, Laegreid, Li, Maathuis, Maathuis, Marschner, Mikkelsen, Munemasa, Nakano, Okushima, Oria-Hernandez, Otterhag, Pandey, Penninckx, Perez-Amador, Reinbothe, Reymond, Ross, Schachtman, Shin, Shin, Sparla, Staswick, Staswick, Staswick, Sun, Syers, Thines, Tschoep, Vernoud, Véry, Walker, Westphal, Xie, Xu, Yamaguchi-Shinozaki, Yan, Zimmermann   +66 more
core   +6 more sources

Context‐Specific Metabolic Alterations in HPRT1 Knockout Cells Within a 3D Culture System

Cancer Medicine, Volume 14, Issue 23, December 2025.
Cancer metabolism studies in 2D culture models often overlook the in vivo complexity. We found that HPRT1 knockout suppressed cell proliferation in 3D and in vivo, but had minimal effect in 2D. Metabolomic analysis also revealed that HPRT1 knockout increased carnosine production via the β‐alanine pathway in 3D cultures. ABSTRACT Background Cancer cells
Sho Tabata, Ichiro Fujimoto, Tomoyoshi Soga, Hideki Makinoshima   +3 more
wiley   +1 more source

Modeling cancer metabolism on a genome scale [PDF]

, 2015
Cancer cells have fundamentally altered cellular metabolism that is associated with their tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new key metabolic alterations in cancer have been established over the last
Barbara Chaneton, Eyal Gottlieb, Eytan Ruppin, Keren Yizhak, Kiuru M, Li L, Lobo C, Som P, Vazquez‐Martin A   +8 more
core   +1 more source