Results 1 to 10 of about 4,126 (159)

The causal relationships between mitochondria and six types of cancer: a Mendelian randomization study [PDF]

BMC Cancer
Background Mitochondria play a multifaceted role in tumorigenesis, influencing energy metabolism, redox balance, and apoptosis. However, whether mitochondrial traits causally affect cancer risk remains unclear.
Jincheng Tang, Jingting Zhang, Renyi Yang, Hongyao Chen, Xiaopeng Yu, Wei Peng, Puhua Zeng   +6 more
doaj   +3 more sources

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity [PDF]

Diabetes & Metabolism Journal, 2014
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and ...
In-Kyu Lee
doaj   +2 more sources

The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4 [PDF]

Diabetes & Metabolism Journal, 2023
Sarcopenia, defined as a progressive loss of muscle mass and function, is typified by mitochondrial dysfunction and loss of mitochondrial resilience. Sarcopenia is associated not only with aging, but also with various metabolic diseases characterized by ...
Min-Ji Kim, Ibotombi Singh Sinam, Zerwa Siddique, Jae-Han Jeon, In-Kyu Lee   +4 more
doaj   +1 more source

Effects of Acute Hypoxic Stress on Physiological and Hepatic Metabolic Responses of Triploid Rainbow Trout (Oncorhynchus mykiss)

Frontiers in Physiology, 2022
This experiment simulated the hypoxic environment caused by actual production operations in fish farming (i.e., catching, gathering, transferring, and weighting) to study the effects of acute hypoxic conditions on the physiological and metabolic ...
Buying Han, Buying Han, Yuqiong Meng, Haining Tian, Changzhong Li, Yaopeng Li, Caidan Gongbao, Wenyan Fan, Rui Ma   +8 more
doaj   +1 more source

Bidirectional Two-Sample Mendelian Randomization Analysis Unveils a Causal Correlation of Mitochondrial Function-Related Proteins with the Risk of Diabetic Nephropathy

International Journal of Clinical Practice
Objective. The genuine causal nexus between mitochondrial function-related proteins and diabetic nephropathy remains enigmatic and arduous to delineate conclusively.
Siyuan Song, Jiangyi Yu
doaj   +1 more source

PDK4 expression and tumor aggressiveness in prostate cancer. [PDF]

Investig Clin Urol
Lee EH, Ha YS, Yoon BH, Jeon M, Park DJ, Kim J, Kang JK, Chung JW, Kim BS, Choi SH, Kim HT, Kim TH, Yoo ES, Kwon TG.   +13 more
europepmc   +1 more source

Acute kidney injury through a metabolic lens: pathological reprogramming mechanisms and clinical translation potential. [PDF]

Front Physiol
Gao J, Huang L, Zhang Y, Wei L, Yu Z, Xing Y, Yuan J, Ning X, Sun S.   +8 more
europepmc   +1 more source

Renometabolic disorder in experimental rat model of polycystic ovarian syndrome is reversed by acetate-mediated inhibition of pyruvate dehydrogenase kinase 4. [PDF]

BMC Nephrol
Areloegbe SE, Atuma CL, Aturamu A, Ajadi IO, Adelekan OE, Ajadi MB, Akintayo CO, Omoruyi GO, Onyekweli SO, Anifowose OF, Amusa OA, Ajayi K, Oyewole PA, Adegoke TE, Olaniyi KS.   +14 more
europepmc   +1 more source

Relationship Between Mitochondrial Biological Function and Breast Cancer: An Approach Based on Mendelian Randomization Analysis. [PDF]

Breast J
Miao S, Ni Q, Fang J.
europepmc   +1 more source

Mechanical Force Triggers Macrophage Pyroptosis and Sterile Inflammation by Disrupting Cellular Energy Metabolism. [PDF]

Int J Mol Sci
Tan H, Yang G, Zhu Y, He X, Yang L, Hu Y, Zheng L.   +6 more
europepmc   +1 more source