Results 1 to 10 of about 10,383 (229)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity [PDF]

Diabetes & Metabolism Journal, 2014
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and ...
In-Kyu Lee
doaj   +2 more sources

A Consecutive Genome Engineering Method Reveals a New Phenotype and Regulation of Glucose and Glycerol Utilization in <i>Clostridium Pasteurianum</i>. [PDF]

Eng Life Sci
ABSTRACT Clostridium pasteurianum is a microorganism for production of 1,3‐propanediol (1,3‐PDO) and butanol, but suffers from lacking genetic tools for metabolic engineering to improve product titers. Furthermore, previous studies of C. pasteurianum have mainly focused on single genomic modification.
Nguyen T, Meleski LWG, Belavatta MP, Gurumoorthi S, Zhang C, Heins AL, Zeng AP.   +6 more
europepmc   +2 more sources

The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4 [PDF]

Diabetes & Metabolism Journal, 2023
Sarcopenia, defined as a progressive loss of muscle mass and function, is typified by mitochondrial dysfunction and loss of mitochondrial resilience. Sarcopenia is associated not only with aging, but also with various metabolic diseases characterized by ...
Min-Ji Kim, Ibotombi Singh Sinam, Zerwa Siddique, Jae-Han Jeon, In-Kyu Lee   +4 more
doaj   +1 more source

A deeply branching thermophilic bacterium with an ancient acetyl-CoA pathway dominates a subsurface ecosystem [PDF]

, 2012
A nearly complete genome sequence of Candidatus ‘Acetothermum autotrophicum’, a presently uncultivated bacterium in candidate division OP1, was revealed by metagenomic analysis of a subsurface thermophilic microbial mat community.
A Stamatakis, A Teske, AK Kaster, AL Brioukhanov, Atsushi Toyoda, AY Mulkidjanian, B Boussau, D Wu, DJ Tobler, DS Kelley, E Biegel, E Biegel, E Pierce, EF DeLong, EG Nisbert, F Nikitin, FD Ciccarelli, G Proskurowski, G Wächtershäuser, Gab-Joo Chee, H Hirayama, H Kimura, H Noguchi, H Takami, H Takami, H Takami, Hideki Noguchi, Hideto Takami, I Uchiyama, I Uchiyama, Ikuo Uchiyama, JA Baross, Jack Anthony Gilbert, JB Corliss, JR Torre, K Takai, K Takai, K Takai, KC Costa, Ken Takai, M Toei, M Wu, M Wu, Masahira Hattori, MB Scott, MS Rappé, N Saitou, O White, P Hugenholtz, R Caspi, R Chenna, RF Say, RT Thauer, S Guindon, S Kato, Shinro Nishi, T Murata, T Nunoura, T Nunoura, T Sakiyama, T Shibuya, Takehiko Itoh, Takuro Nunoura, TM Lowe, V Müller, W Martin, W Martin, W Martin, Wataru Arai, Yoshihiro Takaki   +69 more
core   +19 more sources

Effects of Acute Hypoxic Stress on Physiological and Hepatic Metabolic Responses of Triploid Rainbow Trout (Oncorhynchus mykiss)

Frontiers in Physiology, 2022
This experiment simulated the hypoxic environment caused by actual production operations in fish farming (i.e., catching, gathering, transferring, and weighting) to study the effects of acute hypoxic conditions on the physiological and metabolic ...
Buying Han, Buying Han, Yuqiong Meng, Haining Tian, Changzhong Li, Yaopeng Li, Caidan Gongbao, Wenyan Fan, Rui Ma   +8 more
doaj   +1 more source

Cancer cell metabolism in hypoxia: Role of HIF-1 as key regulator and therapeutic target [PDF]

, 2021
In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells. Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is fundamental for bioenergetics.
Convertini P., Iacobazzi V., Infantino V., Santarsiero A., Todisco S.   +4 more
core   +1 more source

Lipid metabolism in pancreatic cancer: emerging roles and potential targets

Cancer Communications, Volume 42, Issue 12, Page 1234-1256, December 2022., 2022
Abstract Pancreatic cancer is one of the most serious health issues in developed and developing countries, with a 5‐year overall survival rate currently <9%. Patients typically present with advanced disease due to vague symptoms or lack of screening for early cancer detection.
Xinpeng Yin, Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Chengcheng Wang, Qiang Xu   +6 more
wiley   +1 more source

Epipolythiodioxopiperazine‐Based Natural Products: Building Blocks, Biosynthesis and Biological Activities

ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
Housing sulfur: Certain fungi produce diketopiperazine compounds with a transannular sulfur bridge. These so‐called epipolythiodioxopiperzines are toxic by non‐specifically interacting with intracellular proteins and contribute to fungal pathogenicity. Producer strains serve as bio‐pesticides but also question safety of food fermentation.
Eva M. Huber
wiley   +1 more source

Electron transport phosphorylation in rumen butyrivibrios: unprecedented ATP yield for glucose fermentation to butyrate. [PDF]

, 2015
From a genomic analysis of rumen butyrivibrios (Butyrivibrio and Pseudobutyrivibrio sp.), we have re-evaluated the contribution of electron transport phosphorylation (ETP) to ATP formation in this group.
Firkins, Jeffrey L, Hackmann, Timothy J
core   +5 more sources

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source