Results 11 to 20 of about 4,126 (159)

Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes. [PDF]

J Biol Chem
Pyruvate dehydrogenase kinase (PDK) 1 is one of four isozymes that inhibit the oxidative decarboxylation of pyruvate to acetyl-CoA via pyruvate dehydrogenase. PDK activity is elevated in fasting or starvation conditions to conserve carbohydrate reserves.
Atser MG, Wenyonu CD, Rowe EM, Leung CLK, Cen HH, Queathem ED, Liu LT, Moravcova R, Rogalski J, Perrin D, Crawford P, Foster LJ, Alcazar A, Johnson JD.   +13 more
europepmc   +2 more sources

Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes

Cell Death and Disease, 2023
Hyperglycemia-induced aberrant glucose metabolism is a causative factor of neurodegeneration and cognitive impairment in diabetes mellitus (DM) patients.
Yuan Yao, Jiaming Shi, Chunlai Zhang, Wei Gao, Ning Huang, Yaobei Liu, Weiwen Yan, Yingguang Han, Wenjuan Zhou, Liang Kong   +9 more
semanticscholar   +1 more source

TNFα increases the degradation of pyruvate dehydrogenase kinase 4 by the Lon protease to support proinflammatory genes

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Tumor necrosis factor alpha (TNFα) treatment of primary human endothelial cells resulted in elevated glucose oxidation mediated by increased pyruvate dehydrogenase (PDH) activity, as determined by metabolic tracing.
Nabil E. Boutagy, J. W. Fowler, Kariona A. Grabińska, Rebecca L. Cardone, Qiushi Sun, Kyla R Vazquez, Michael B. Whalen, Xiaolong Zhu, Raja Chakraborty, Kathleen A. Martin, Michael Simons, C. Romanoski, R. Kibbey, W. Sessa   +13 more
semanticscholar   +1 more source

Pyruvate Dehydrogenase A1 Phosphorylated by Insulin Associates with Pyruvate Kinase M2 and Induces LINC00273 through Histone Acetylation

Biomedicines, 2022
Insulin potently promotes cell proliferation and anabolic metabolism along with a reduction in blood glucose levels. Pyruvate dehydrogenase (PDH) plays a pivotal role in glucose metabolism.
A. J. Hossain, Rokibul Islam Shuvo, Jae‐Gyu Kim, Oyungerel Dogsom, K. Cap, Jae-Bong Park   +5 more
semanticscholar   +1 more source

Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma

Frontiers in Oncology, 2021
Background The mitochondrial pyruvate dehydrogenase complex (PDC) link glycolysis to the tricarboxylic acid cycle by decarboxylating pyruvate to acetyl coenzyme A irreversibly.
Y. Kuo, T. Chan, Hong-Yue Lai, Tzu-Ju Chen, Li-Ching Wu, C. Hsing, Chien-Feng Li   +6 more
semanticscholar   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia

The FEBS Journal, 2022
Cancer cells, when exposed to the hypoxic tumour microenvironment, respond by activating hypoxia‐inducible factors (HIFs). HIF‐1 mediates extensive metabolic re‐programming, and expression of HIF‐1α, its oxygen‐regulated subunit, is associated with poor ...
Angeliki Karagiota, Amalia Kanoura, E. Paraskeva, G. Simos, G. Chachami   +4 more
semanticscholar   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

The pyruvate dehydrogenase kinase 2 (PDK2) is associated with conidiation, mycelial growth, and pathogenicity in Fusarium graminearum

Food Production, Processing and Nutrition, 2020
Pyruvate dehydrogenase kinase (PDK) is a mitochondrial enzyme in a variety of eukaryotes, including the plant pathogen Fusarium graminearum. This enzyme can reduce the oxidation of glucose to acetyl-coA by phosphorylation and selectively inhibits the ...
Tao Gao, D. He, Xin Liu, Fang Ji, Jianhong Xu, J. Shi   +5 more
semanticscholar   +1 more source

Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer

Frontiers in Oncology, 2022
Background Pyruvate dehydrogenase (PDH) complex converts pyruvate into acetyl-CoA by pyruvate decarboxylation, which drives energy metabolism during cell growth, including prostate cancer (PCa) cell growth.
C. Nunes-Xavier, J. Mingo, Maite Emaldi, K. Flem-Karlsen, G. Mælandsmo, Ø. Fodstad, R. Llarena, J. López, R. Pulido   +8 more
semanticscholar   +1 more source