Results 21 to 30 of about 4,126 (159)

Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype

Frontiers in Immunology, 2019
Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits the pyruvate dehydrogenase-mediated conversion of ...
Byong-Keol Min, Sungmi Park, Hyeon-Ji Kang, Dong Wook Kim, H. Ham, Chae-Myeong Ha, Byung-Jun Choi, Jung Yi Lee, C. J. Oh, E. Yoo, Hui Eon Kim, Byung-Gyu Kim, Jae-Han Jeon, Do Young Hyeon, D. Hwang, Yong-Hoon Kim, Chul-Ho Lee, Taeho Lee, Jung-whan Kim, Yeon-Kyung Choi, K. Park, A. Chawla, Jongsoon Lee, Robert A. Harris, In-kyu Lee   +24 more
semanticscholar   +1 more source

Reprogramming of aerobic glycolysis in non‐transformed mouse liver with pyruvate dehydrogenase complex deficiency

Physiological Reports, 2021
The Pyruvate Dehydrogenase Complex (PDC), a key enzyme in glucose metabolism, catalyzes an irreversible oxidative decarboxylation reaction of pyruvate to acetyl‐CoA, linking the cytosolic glycolytic pathway to mitochondrial tricarboxylic acid cycle and ...
M. Patel, S. Mahmood, Jiwon Jung, T. Rideout   +3 more
semanticscholar   +1 more source

Fine tuning the glycolytic flux ratio of EP-bifido pathway for mevalonate production by enhancing glucose-6-phosphate dehydrogenase (Zwf) and CRISPRi suppressing 6-phosphofructose kinase (PfkA) in Escherichia coli

Microbial Cell Factories, 2021
Background Natural glycolysis encounters the decarboxylation of glucose partial oxidation product pyruvate into acetyl-CoA, where one-third of the carbon is lost at CO 2 .
Ying Li, He Xian, Ya Xu, Yuan Zhu, Zhijie Sun, Qian Wang, Q. Qi   +6 more
semanticscholar   +1 more source

MiR-422a regulates cellular metabolism and malignancy by targeting pyruvate dehydrogenase kinase 2 in gastric cancer

Cell Death and Disease, 2018
Increasing evidence indicates that dysregulation of microRNAs (miRNAs) plays a crucial role in human malignancies. Here, we showed that microRNA-422a (miR-422a) expression was dramatically downregulated in gastric cancer (GC) samples and cell lines ...
Zhongyuan He, Zheng Li, Xuan Zhang, Kai Yin, Weizhi Wang, Zhi-xiu Xu, Bowen Li, Lei Zhang, Jianghao Xu, G. Sun, Lu Wang, Qing Li, Xiaoxu Huang, Lu Zhang, Diancai Zhang, Hao Xu, Zekuan Xu   +16 more
semanticscholar   +1 more source

Novel role of pyruvate dehydrogenase PDH ーregulation of histone acetylation and gene expression in breast cancer cells

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2021
When organisms are exposed to hypoxic condition, physiological processes such as metabolism, respiration, and erythropoiesis are adjusted for adaptation.
Nakayama Koh
semanticscholar   +1 more source

Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex

Journal of Biological Chemistry, 2018
The pyruvate dehydrogenase complex (PDC) is a multienzyme assembly that converts pyruvate to acetyl-CoA. As pyruvate and acetyl-CoA play central roles in cellular metabolism, understanding PDC regulation is pivotal to understanding the larger metabolic ...
Alla V Klyuyeva, A. Tuganova, N. Kedishvili, K. M. Popov   +3 more
semanticscholar   +1 more source

Coenzyme A–mediated degradation of pyruvate dehydrogenase kinase 4 promotes cardiac metabolic flexibility after high-fat feeding in mice

Journal of Biological Chemistry, 2018
Cardiac energy is produced primarily by oxidation of fatty acids and glucose, with the relative contributions of each nutrient being sensitive to changes in substrate availability and energetic demand. A major contributor to cardiac metabolic flexibility
Christopher M Schafer, Zachary T. Young, C. Makarewich, Abdallah Elnwasany, Caroline S. Kinter, M. Kinter, L. Szweda   +6 more
semanticscholar   +1 more source

RNAi-mediated silencing of a pyruvate dehydrogenase kinase enhances triacylglycerol biosynthesis in the oleaginous marine alga Nannochloropsis salina

Scientific Reports, 2017
Oleaginous microalgae have been emerging as the third-generation feedstocks for biofuel production. Genetic manipulation for improving triacylglycerol (TAG) accumulation represents a promising approach towards the economics of microalgal biofuels. Acetyl-
Xiaonian Ma, Lina Yao, Bo Yang, Yuan-Kun Lee, Feng Chen, Jin Liu   +5 more
semanticscholar   +1 more source

Fusarium graminearum pyruvate dehydrogenase kinase 1 (FgPDK1) Is Critical for Conidiation, Mycelium Growth, and Pathogenicity

PLoS ONE, 2016
Pyruvate dehydrogenase kinase (PDK) is an important mitochondrial enzyme that blocks the production of acetyl-CoA by selectively inhibiting the activity of pyruvate dehydrogenase (PDH) through phosphorylation.
Tao Gao, Jian Chen, Zhiqi Shi
semanticscholar   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source