Results 141 to 150 of about 140,469 (257)

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

Post-translational modifications of pyruvate dehydrogenase complex in cardiovascular disease. [PDF]

iScience
Guo B, Zhang F, Yin Y, Ning X, Zhang Z, Meng Q, Yang Z, Jiang W, Liu M, Wang Y, Sun L, Yu L, Mu N.   +12 more
europepmc   +1 more source

Effects of Multiple Near‐Infrared LEDs (700, 850, and 980 nm) CW‐PBM on Mitochondrial Respiration and Gene Expression in MG63 Osteoblasts

Journal of Biophotonics, EarlyView.
A multi‐wavelength near infrared LED light source (700–1100 nm) altered mitochondrial respiration and energy production in MG‐63 osteoblastic cells. This LED light source boosted gene expression of the osteogenic markers ALP, RUNX2, BMP, COL1, OPN, and OCN.
Simone Sleep, Deanne H. Hryciw, Laurence J. Walsh, Eliza Ranjit, Nifty Tomy, Praveen R. Arany, Roy George   +6 more
wiley   +1 more source

Pyruvate Dehydrogenase Complex in Neonatal Hypoxic-Ischemic Brain Injury. [PDF]

ACS Pharmacol Transl Sci
Zhou T, Zhong Y, Zhang Y, Zhou Y.
europepmc   +1 more source

Solvent accessibility of E1α and E1β residues with known missense mutations causing pyruvate dehydrogenase complex (PDC) deficiency: Impact on PDC-E1 structure and function. [PDF]

J Inherit Metab Dis, 2022
Ducich NH, Mears JA, Bedoyan JK.
europepmc   +1 more source

Silk Fibroin‐Based Hydrogels Supplemented with Decellularized Extracellular Matrix and Gelatin Facilitate 3D Bioprinting for Meniscus Tissue Engineering

Macromolecular Bioscience, EarlyView.
To engineer meniscus tissue, a combination of silk fibroin, decellularized meniscus extracellular matrix, and gelatin is 3D bioprinted with infrapatellar fat pad‐derived mesenchymal stem cells. Cell addition is found to affect the enzymatic crosslinking and the mechanical properties of the hydrogels, whose Young's modulus matches with human meniscus ...
Jennifer Fritz, Anna‐Christina Moser, Alexander Otahal, Heinz Redl, Andreas H. Teuschl‐Woller, Karl H. Schneider, Stefan Nehrer   +6 more
wiley   +1 more source

Manifestations of X-linked pyruvate dehydrogenase complex deficiency in female PDHA1 carriers. [PDF]

Eur J Neurol
Savvidou A, Sofou K, Eklund EA, Aronsson J, Darin N.   +4 more
europepmc   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Nuclear pyruvate dehydrogenase complex regulates histone acetylation and transcriptional regulation in the ethylene response. [PDF]

Sci Adv
Shao Z, Bian L, Ahmadi SK, Daniel TJ, Belmonte MA, Burns JG, Kotla P, Bi Y, Shen Z, Xu SL, Wang ZY, Briggs SP, Qiao H.   +12 more
europepmc   +1 more source

PGC‐1α Activation by Polyphenols: A Pathway to Thermogenesis

Molecular Nutrition &Food Research, EarlyView.
Polyphenols, derived from dietary sources such as berries, undergo digestion and interact with gut microbiota, leading to their metabolization in the liver. This process influences bile acid composition, which in turn activates PGC1α, a key regulator of mitochondrial biogenesis and thermogenesis.
Nicholas Vannuchi, Luciana Pisani
wiley   +1 more source