British Journal of Pharmacology, EarlyView.Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens +15 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) result from immune self‐tolerance loss, causing tissue damage. Standard treatments targeting late‐stage inflammation often have serious side effects. Artemisinin, known for its antimalarial properties, shows potential immunomodulatory effects.
Fanchao Zhou +4 more
wiley +1 more source
Analysis of the Growth and Metabolites of a Pyruvate Dehydrogenase Complex- Deficient Klebsiella pneumoniae Mutant in a Glycerol-Based Medium. [PDF]
J Microbiol Biotechnol, 2020 Xu D, Jia Z, Zhang L, Fu S, Gong H.
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Inflammation is vital for defence against injury and infection, but excessive inflammation can lead to tissue damage and disease. The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic–pituitary–adrenal axis and the anti‐inflammatory reflex, which limit systemic inflammation.
Evelin C. Cárnio +5 more
wiley +1 more source
Pyruvate dehydrogenase complex-enzyme 2, a new target for Listeria spp. detection identified using combined phage display technologies. [PDF]
Sci Rep, 2020 Moreira GMSG +11 more
europepmc +1 more source
Diatom triacylglycerol metabolism: from carbon fixation to lipid droplet degradation
Biological Reviews, EarlyView.ABSTRACT Diatoms are a prominent microalgae family that has attracted interest for its production of molecules of biotechnological interest. Their fatty acid profile is rich in health‐beneficial omega‐3 eicosapentaenoic acid (EPA). Furthermore, under nutrient‐deprived conditions, many diatom species, notably Phaeodactylum tricornutum, Thalassiosira ...
Victor Murison +3 more
wiley +1 more source
Exploring Long Noncoding RNAs as Regulators of Tumor Ferroptosis: Advances and Challenges
Cancer Science, EarlyView.Long noncoding RNAs (lncRNAs) play pivotal roles in regulating gene expression and are closely associated with cancer progression, prognosis, and therapeutic resistance. This review highlights recent advancements in understanding how lncRNAs modulate ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation ...
Gang Li +3 more
wiley +1 more source
PPARδ and FOXO1 Mediate Palmitate-Induced Inhibition of Muscle Pyruvate Dehydrogenase Complex and CHO Oxidation, Events Reversed by Electrical Pulse Stimulation. [PDF]
Int J Mol Sci, 2020 Chien HC +2 more
europepmc +1 more source
Cell Proliferation, EarlyView.PDHA2, a testis‐specific subunit of pyruvate dehydrogenase, is required for the conversion of pyruvate to acetyl‐CoA. Its absence results in decreased acetyl‐CoA and precursors for metabolites and energy during spermatogenesis. This results in decreased histone acetylation, defective chromosome structure and moderately reduced crossovers, ultimately ...
Guoqiang Wang +9 more
wiley +1 more source
Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes. [PDF]
J Leukoc Biol, 2020 Zhu X +6 more
europepmc +1 more source