Results 191 to 200 of about 156,917 (287)

Nuclear pyruvate dehydrogenase complex regulates histone acetylation and transcriptional regulation in the ethylene response. [PDF]

Sci Adv
Shao Z, Bian L, Ahmadi SK, Daniel TJ, Belmonte MA, Burns JG, Kotla P, Bi Y, Shen Z, Xu SL, Wang ZY, Briggs SP, Qiao H.   +12 more
europepmc   +1 more source

The pyruvate dehydrogenase complex regulates matrix protein phosphorylation and mitophagic selectivity

, 2022
Kolitsida P, Nolic V, Zhou J, Stumpe M, Niemi NM, Dengjel J, Abeliovich H.   +6 more
europepmc   +1 more source

Solvent accessibility of E1α and E1β residues with known missense mutations causing pyruvate dehydrogenase complex (PDC) deficiency: Impact on PDC-E1 structure and function. [PDF]

J Inherit Metab Dis, 2022
Ducich NH, Mears JA, Bedoyan JK.
europepmc   +1 more source

Validation of a Multiparametric, Automated, Macroarray‐Based Assay for the Detection of Autoantibodies in Autoimmune Liver Disease

Journal of Clinical Laboratory Analysis, EarlyView.
The assay exploited a multiparametric and fully automated device applied to CHORUS EVO to validate that the CHORUS Macroarray Liver Diseases kit is a novel procedure for detecting autoantibodies of AIH and PBC. The assay resulted as linear, accurate, sensitive, specific, and able to distinguish between PBC and AIH.
Luigi Raganelli, Tommaso Bandini, Matilde Ilacqua, Helena Cerutti, Alessandra Cartocci, Giulia Tesi, Andrea Ianniello, Thomas Massari, Mirko Berretti, Roberto Centini, Michele Norelli, Alessandra Brogi, Giampaola Pesce, Danilo Villalta, Brunetta Porcelli   +14 more
wiley   +1 more source

Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria‐Induced Apoptosis Pathway

Journal of Clinical Laboratory Analysis, EarlyView.
Inhibition of XPO1 is a promising modality in the treatment of MDS, especially when combined with Venetoclax, which activates mitochondria‐mediated apoptosis and could be a potential target for MDS therapy. ABSTRACT Background Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies that pose a serious health threat.
Xiaohan Liu, Lei Huang, Junzhu Wang, Yixuan Guo, Hongli Shen, Xianghong Zhao, Lanzhu Yue, Zhaoyun Liu, Rong Fu   +8 more
wiley   +1 more source

Pyruvate dehydrogenase complex deficiency masked by septic shock-induced lactic acidosis: a case report. [PDF]

J Int Med Res
Zhou H, Wen Y, Ding H.
europepmc   +1 more source

Proteomic and Metabolomic Profiling Reveal Mitochondrial Transplantation–Mediated Reprogramming in Gastric Cancer Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondria provide multiple functions for cellular physiology. Transplantation of mitochondria isolated from gastric epithelial cells GES‐1 reducing the malignancy of gastric cancer cells AGS was previously reported. To elucidate the underlying mechanisms, TMT‐based proteomic analysis coupling ingenuity pathway software prediction revealed ...
Ping‐Chen Chen, Chen‐Kai Liu, Ching‐Chung Tsai, Erna Sulistyowati, Fu‐An Li, Chung‐Jung Liu, Deng‐Chyang Wu, Shih‐Hsuan Chou, Fu‐Chen Kuo, Bin Huang   +9 more
wiley   +1 more source

Novel Synonymous and Deep Intronic Variants Causing Primary and Secondary Pyruvate Dehydrogenase Complex Deficiency. [PDF]

Hum Mutat
Bruhn H, Naess K, Ygberg S, Peña-Pérez L, Lesko N, Wibom R, Freyer C, Stranneheim H, Wedell A, Wredenberg A.   +9 more
europepmc   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Physiological Interpretation of the Lactate to Pyruvate AUC Ratio for Hyperpolarized [1‐13C]‐Pyruvate Studies

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To explore the relationship between potentially rate‐limiting steps in lactate production and the lactate area‐under‐the‐curve (AUC) to pyruvate AUC ratio for analysis of hyperpolarized (HP) [1‐13C]‐pyruvate data. Theory and Methods Simplifying assumptions are introduced to a pharmacokinetic (PK) model with three physical compartments ...
Ryan T. Boyce, Collin J. Harlan, Qing Wang, Christopher M. Walker, Stephen Y. Lai, Matthew E. Merritt, James A. Bankson   +6 more
wiley   +1 more source