Results 191 to 200 of about 94,657 (246)

Ageing alters cysteine oxidation‐regulated redox signalling in skeletal muscle: Integrative omics and AI‐based structural predictions

Experimental Physiology, EarlyView.
Abstract Ageing is associated with loss of skeletal muscle mass and strength (sarcopenia) and disrupted redox homeostasis. Redox signalling is essential for muscle adaptation, yet the mechanisms by which ageing disrupts cysteine‐based regulation are poorly defined. The drivers of site‐specific reactivity and signalling specificity in aged muscle remain
Ufuk Ersoy, Malcolm J. Jackson
wiley   +1 more source

Ovarian hormone loss modifies the nucleic acid cargo of circulating extracellular vesicles and skeletal muscle metabolism after acute exercise in rats

Experimental Physiology, EarlyView.
Abstract Loss of ovarian hormones (i.e., menopause) leads to negative effects on metabolic health. While exercise offers significant benefits, it seems to be insufficient to completely reverse these changes. The mechanisms by which exercise conveys the effects throughout the body are still poorly understood.
Veera Puumalainen, Anni Maja, Tia‐Marje Korhonen, Tuuli A. Nissinen, Eero Hulkko, Janne A. Ihalainen, Maarit Lehti, Sira Karvinen   +7 more
wiley   +1 more source

The Pyruvate Dehydrogenase Complex from Azotobacter vinelandii

, 1994
de Kok, A., Berg, A., van Berkel, W.J.H., Fabisz-Kijowska, A., Westphal, A.H., van den Akker, F., Mattevi, A., Hol, W.G.J.   +7 more
openaire   +3 more sources

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The Pyruvate Dehydrogenase Multienzyme Complex

Angewandte Chemie International Edition in English, 1975
AbstractThe three enzymes pyruvate dehydrogenase, dihydrolipoamide transacetylase, and dihydrolipoamide dehydrogenase constitute the pyruvate dehydrogenase multienzyme complex of E. coli; in mammals the complex also contains a kinase and a phosphatase.
Ferdinand Hucho
exaly   +3 more sources

The pyruvate dehydrogenase complex during aging

Mechanisms of Ageing and Development, 1984
Acetylcholine synthesis and pyruvate oxidation decline with age. To determine the role of the pyruvate dehydrogenase complex in these age-related deficits, its activity and activation state were measured in vivo and in vitro in the brains of 3-, 10- and 30-month-old mice.
Gary Gibson, Christine Peterson
exaly   +3 more sources

Purification and properties of the Ascaris pyruvate dehydrogenase complex

Biochimica Et Biophysica Acta - Biomembranes, 1979
The pyruvate dehyhdrogenase complex (pyruvate:lipoate oxidoreductase (decarboxylating and acceptor-acetylating), EC 1.2.4.1) has been isolated from Ascaris muscle mitochondria and purified to near homogeneity by differential centrifugation, (NH4)2SO4 fractionation and calcium phosphate gel-cellulose chromatography.
Richard Komuniecki, Patricia R Komuniecki, H J Saz   +2 more
exaly   +3 more sources

The biochemistry of the pyruvate dehydrogenase complex

Biochemistry and Molecular Biology Education, 2003
Mulchand Patel
exaly   +2 more sources

Disorders of the pyruvate dehydrogenase complex

Journal of Inherited Metabolic Disease, 1986
AbstractPyruvate dehydrogenase deficiency may be a non‐specific consequence of many different neurological degenerative disorders. There are also serious methodological problems in estimating the activity of this enzyme complex.
D, Stansbie, S J, Wallace, C, Marsac
openaire   +2 more sources

Regulation of the pyruvate dehydrogenase complex

Biochemical Society Transactions, 2006
The PDC (pyruvate dehydrogenase complex) plays a central role in the maintenance of glucose homoeostasis in mammals. The carbon flux through the PDC is meticulously controlled by elaborate mechanisms involving post-translational (short-term) phosphorylation/dephosphorylation and transcriptional (long-term) controls.
M S, Patel, L G, Korotchkina
openaire   +2 more sources