Results 191 to 200 of about 42,696 (258)

Pharmacological manipulation of liver fibrosis progression using novel HDAC6 inhibitors

The FEBS Journal, Volume 292, Issue 13, Page 3397-3411, July 2025.
Chronic liver injury can lead to severe conditions such as cirrhosis and liver cancer. Unfortunately, there are no effective treatments to halt or reverse liver fibrosis, which makes new therapeutic strategies essential. This study focuses on the role of histone deacetylases (HDACs) in liver fibrosis, particularly HDAC6.
Maria Teresa Borrello, Dusan Ruzic, Hannah Paish, Eleanor Graham, Amy L. Collins, Rebecca Scott, Sam Higginbotham, Branko Radovic, Glyn Nelson, David Bulmer, Lee A. Borthwick, Stuart M. Robinson, Jeremy French, John Moir, Steve A. White, Colin Wilson, Sanjay Pandanaboyana, John Hammond, Rohan Thakkar, Wasfi Alrawashdeh, Rodrigo Figueiredo, Milos Petkovic, Katarina Nikolic, Fiona Oakley, Derek A. Mann, Jelena Mann   +25 more
wiley   +1 more source

Hepatic Form of Dihydrolipoamide Dehydrogenase Deficiency (DLDD): Phenotypic Spectrum, Laboratory Findings, and Therapeutic Approaches in 52 Patients. [PDF]

J Inherit Metab Dis
Hammann N, Staufner C, Schlieben LD, Dezsőfi-Gottl A, Feichtinger RG, Häberle J, Junge N, Konstantopoulou V, Kopajtich R, McLin V, Rymen D, Slavetinsky C, Sturm E, Mayr JA, Wagner M, Kölker S, Prokisch H, Hoffmann GF, Lenz D.   +18 more
europepmc   +1 more source

Targeting the Liver Serine Protease TMPRSS6 Ameliorates Steatosis and Attenuates Fibrosis in Experimental MASLD

Liver International, Volume 45, Issue 7, July 2025.
ABSTRACT Background and Aims Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common cause of liver disease and a leading contributor to liver‐related morbidity and mortality. Currently, no pharmacological approach has demonstrated consistent and long‐lasting benefits across all patients.
Mariateresa Pettinato, Valeria Furiosi, Rossana Carleo, Letizia Bavuso Volpe, Shuling Guo, Valeria Mannella, Giovanna Musco, Enrica Gilberti, Giuseppe De Palma, Giorgia Federico, Francesca Carlomagno, Alessandro Cherubini, Serena Pelusi, Anxhela Dano, Antonella Nai, Luca Valenti, Sandro Altamura, Alessia Pagani, Laura Silvestri   +18 more
wiley   +1 more source

Lactate and lactylation in the kidneys: Current advances and prospects (Review). [PDF]

Int J Mol Med
Li X, Hu L, Hu Q, Jin H.
europepmc   +1 more source

Deciphering the Regulatory Networks of the Migrasome‐Associated Cell Subpopulation in Heterotopic Ossification via Multi‐Omics Analysis

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Mesenchymal lineage cells (MLin) are identified as a pivotal migrasome‐associated subpopulation driving the progression of heterotopic ossification (HO) via migrasome score analysis in single‐cell transcriptomics. HdWGCNA and random forest analysis reveal Ppib and Tagln as key genes, validated by clinical transcriptomic datasets. Integrated multi‐omics
Guanzhi Li, Xiao Deng, Tong Li, Yuchen Liu, Lei Tan, Kairui Zhang, Bin Yu   +6 more
wiley   +1 more source

Therapeutic Targeting of Decr1 Ameliorates Cardiomyopathy by Suppressing Mitochondrial Fatty Acid Oxidation in Diabetic Mice. [PDF]

J Cachexia Sarcopenia Muscle
Lu QB, Sun HT, Zhou K, Su JB, Meng XY, Chen G, Zhang AY, Xu AJ, Zhao CY, Zhang Y, Wang Y, Qiu HB, Lv ZL, Bao ZY, Zhu J, Xiao F, Zhu XX, Sun HJ.   +17 more
europepmc   +1 more source

Development of Photo‐Biocatalytic Redox System for Asymmetric Synthesis of Optically Active Amines Using Blue Light and Transaminases. A Case Study Toward Mavacamten

Advanced Synthesis &Catalysis, Volume 367, Issue 12, June 26, 2025.
Abstract α‐Chiral amines are versatile building blocks for the asymmetric synthesis of optically pure high‐added‐value chemicals, including pharmaceuticals, agrochemicals, and natural products. Herein, we report a one‐pot, two‐step sequential deracemization of racemic sec‐alcohols to optically enriched primary amines throught a photo‐biocatalytic ...
Natalia Antos, Aleksandra Rudzka, Anna Hoser, Tamara Reiter, Wolfgang Kroutil, Paweł Borowiecki   +5 more
wiley   +1 more source

A Systematic Review of Thiamine Supplementation in Improving Diabetes and Its Related Cardiovascular Dysfunction. [PDF]

Int J Mol Sci
Serra M, Mollace R, Ritorto G, Ussia S, Altomare C, Tavernese A, Preianò M, Palma E, Muscoli C, Mollace V, Macrì R.   +10 more
europepmc   +1 more source

Affinity‐Based Protein Profiling Reveals IDH2 as a Mitochondrial Target of Cannabinol in Receptor‐Independent Neuroprotection

Chemistry – A European Journal, Volume 31, Issue 33, June 12, 2025.
A chemical probe CBN‐P based on the neuroprotective cannabinoid cannabinol (CBN) was developed and synthesized. CNB‐P was found to have a similar mechanism of action as the parent compound and was used in click‐CLEM microscopy studies and affinity‐based protein profiling to identify the mitochondrial protein isocitrate dehydrogenase 2 (IDH2) as one ...
Eva Schaller, Stephanie Lamer, Andreas Schlosser, Christian Stigloher, Pamela Maher, Michael Decker   +5 more
wiley   +1 more source

Assessing impacts of mitochondrial dysfunction on axonal microtubule bundles as potential mechanism in neurodegeneration

Murray-Cors S, Owens M, Liew Y, Day M, Cairns W, Prokop A.   +5 more
europepmc   +1 more source