Results 61 to 70 of about 16,904 (180)
British Journal of Haematology, EarlyView.Data from a large cohort of individuals referred for NGS testing evaluate the utility of next‐generation sequencing in clinical practice for diagnosing hereditary haemolytic anaemias.
Jorune Balciuniene +10 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) result from immune self‐tolerance loss, causing tissue damage. Standard treatments targeting late‐stage inflammation often have serious side effects. Artemisinin, known for its antimalarial properties, shows potential immunomodulatory effects.
Fanchao Zhou +4 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Inflammation is vital for defence against injury and infection, but excessive inflammation can lead to tissue damage and disease. The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic–pituitary–adrenal axis and the anti‐inflammatory reflex, which limit systemic inflammation.
Evelin C. Cárnio +5 more
wiley +1 more source
Exploring Long Noncoding RNAs as Regulators of Tumor Ferroptosis: Advances and Challenges
Cancer Science, EarlyView.Long noncoding RNAs (lncRNAs) play pivotal roles in regulating gene expression and are closely associated with cancer progression, prognosis, and therapeutic resistance. This review highlights recent advancements in understanding how lncRNAs modulate ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation ...
Gang Li +3 more
wiley +1 more source
Cell Proliferation, EarlyView.PDHA2, a testis‐specific subunit of pyruvate dehydrogenase, is required for the conversion of pyruvate to acetyl‐CoA. Its absence results in decreased acetyl‐CoA and precursors for metabolites and energy during spermatogenesis. This results in decreased histone acetylation, defective chromosome structure and moderately reduced crossovers, ultimately ...
Guoqiang Wang +9 more
wiley +1 more source
Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases
Cell Proliferation, EarlyView.HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang +4 more
wiley +1 more source
Developmental Medicine &Child Neurology, EarlyView.Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes +6 more
wiley +1 more source
European Journal of Clinical Investigation, EarlyView.This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone +28 more
wiley +1 more source
FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries
The FEBS Journal, EarlyView.This paper reviews a decade of research on FAHD1, an important yet underappreciated enzyme in mitochondrial metabolism. FAHD1 plays a crucial role in energy production, oxidative stress regulation, and processes related to aging and overall health.
Elia Cappuccio +9 more
wiley +1 more source
The FEBS Journal, EarlyView.Parkinson's disease (PD) is a severe brain disorder caused by the loss of dopaminergic neurons. This study found that activating the enzyme glutamate dehydrogenase (GDH), by using the GDH activator BCH, protects cells and improves their energy production. It also highlights the previously undescribed role of EAAT3 in GDH‐dependent protection against PD
Alessandra Preziuso +7 more
wiley +1 more source