Results 141 to 150 of about 181,145 (327)

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Pyruvate Kinase and Gastric Cancer: A Potential Marker

European Medical Journal, 2018
Gastric cancer is the second most common cause of cancer-related deaths worldwide, and the 5-year overall survival rate for advanced gastric cancer is ≤25%.
Filipa Macedo, Kátia Ladeira, Adhemar Longatto-Filho, Sandra F. Martins   +3 more
doaj  

The Central Role of Glucokinase in Glucose Homeostasis: A Perspective 50 Years After Demonstrating the Presence of the Enzyme in Islets of Langerhans

Frontiers in Physiology, 2019
It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to glucose homeostasis in mammals. This includes other cells in endocrine
Franz M. Matschinsky, David F. Wilson
doaj   +1 more source

Bovine heart pyruvate dehydrogenase kinase stimulation by monovalent ions

Journal of Biological Chemistry, 1989
The effects of monovalent ions on endogenous pyruvate dehydrogenase (PDH) kinase activity in purified bovine heart pyruvate dehydrogenase complex were investigated. Activity of PDH kinase was stimulated 1.9-, 1.95-, 1.65-, and 1.4-fold by 10 mM K+, Rb+, NH+4, and Cs+, respectively, whereas Na+ and Li+ had no effect on PDH kinase activity.
J G, Robertson, L L, Barron, M S, Olson
openaire   +2 more sources

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α

Genes and Diseases
Pyruvate dehydrogenase kinase 1 (PDK1) phosphorylates the pyruvate dehydrogenase complex, which inhibits its activity. Inhibiting pyruvate dehydrogenase complex inhibits the tricarboxylic acid cycle and the reprogramming of tumor cell metabolism to ...
Yu Wei, Dian Zhang, He Shi, Husun Qian, Hongling Chen, Qian Zeng, Fangfang Jin, Yan Ye, Zuli Ou, Minkang Guo, Bianqin Guo, Tingmei Chen   +11 more
doaj   +1 more source

Industrial strategies to minimize glycerol formation in ethanol fermentation by conventional Saccharomyces cerevisiae

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Industrial ethanol production faces the challenge of balancing metabolic efficiency with the minimization of byproducts such as glycerol, whose formation is intensified by osmotic, thermal, oxidative, and nutritional stresses. In the literature, two main approaches stand out for modulating its synthesis: the use of genetically modified strains
Lorena M. F. Leite, Silvio R. Andrietta, Telma T. Franco   +2 more
wiley   +1 more source

Effects of seven days’ fasting on physical performance and metabolic adaptation during exercise in humans

Nature Communications
Humans have, throughout history, faced periods of starvation necessitating increased physical effort to gather food. To explore adaptations in muscle function, 13 participants (7 males and 6 females) fasted for seven days. They lost 4.6 ± 0.3 kg lean and
Kristoffer J. Kolnes, Emelie T. F. Nilsen, Steffen Brufladt, Allison M. Meadows, Per B. Jeppesen, Øyvind Skattebo, Egil I. Johansen, Jesper B. Birk, Kurt Højlund, Janne Hingst, Bjørn S. Skålhegg, Rasmus Kjøbsted, Julian L. Griffin, Anders J. Kolnes, Stephen O’Rahilly, Jørgen F. P. Wojtaszewski, Jørgen Jensen   +16 more
doaj   +1 more source

Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells

Cancer & Metabolism, 2019
Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic cancer remains controversial.
Lei Yu, Shao Thing Teoh, Elliot Ensink, Martin P. Ogrodzinski, Che Yang, Ana I. Vazquez, Sophia Y. Lunt   +6 more
doaj   +1 more source

Development of a Jacketed Breathable Shake Flask With Process Monitoring, Control, and Bioreactor‐Like Performance

Biotechnology and Bioengineering, EarlyView.
This article presents the design and evaluation of a gas‐control jacket integrated with a breathable shake flask, enabling precise regulation of dissolved oxygen and carbon dioxide to improve scalability, process control, and culture performance in shaking bioreactors.
Vikash Kumar, Chad Sundberg, Venkatesh Srinivasan, Aaron Thole, Michael Tolosa, Govind Rao   +5 more
wiley   +1 more source