Results 121 to 130 of about 80,914 (291)
The effect of phosphorylation on pyruvate dehydrogenase
, 1995 Phosphorylation of the pyruvate dehydrogenase component (E1) of the muscle pyruvate dehydrogenase complex (PDC) by E1-kinase inhibits substrate conversion both in oxidative and non-oxidative reactions.
Khailova, L.S. +2 more
core +1 more source
Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy
BMEMat, EarlyView.This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma +9 more
wiley +1 more source
Interdomain communications in pyruvate dehydrogenase kinase 2
The FASEB Journal, 2007 The activity of pyruvate dehydrogenase kinase (PDHK) is regulated by a great variety of metabolites such as pyruvate, coenzyme A (CoA), acetyl‐CoA, NAD+, and NADH. Accordingly, recent structural studies conducted on pyruvate dehydrogenase kinase 2 (PDHK2) identified at least three allosteric sites, which participate in the binding of lipoyl‐bearing ...
Alla Klyuyeva +2 more
openaire +1 more source
, 1996 Isolated hepatocytes were prepared from the periportal and perivenous regions of the liver of 18-h-starved rats. These showed characteristic enzyme patterns and an enhanced rate of ureagenesis in the periportal cells; however, total cellular ATP content ...
Michael Titheradge (4460512) +1 more
core
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
Enhanced strategies for cuproptosis‐like death in bacterial infection treatment
BMEMat, EarlyView.This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang +7 more
wiley +1 more source
Evaluation of on growth and metabolism of NB-1691, an MYCN-amplified neuroblastoma cell line
Tumor Biology, 2018 Outcomes of children with high grade neuroblastoma remain poor despite multi-agent chemotherapy regimens. Rhodiola crenulata extracts display anti-neoplastic properties against several cancers including breast cancer, melanoma, and glioblastoma.
Kaitlyn E Wong +7 more
doaj +1 more source
Genome-Wide Proteomics and Quantitative Analyses on Halophilic Archaea [PDF]
, 2008 The aerobic, haloalkaliphilic archaeon Natronomonas pharaonis is able to survive in salt-saturated lakes of pH 11. With genome-wide shotgun proteomics, 886 soluble proteins (929 proteins in total) of the theoretical Natronomonas pharaonis soluble ...
Konstantinidis, Konstantinos +1 more
core
BMEMat, EarlyView.Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang +9 more
wiley +1 more source