Results 141 to 150 of about 80,914 (291)

Pyruvate and Ac-CoA metabolism.

, 2014
Pi: inorganic phosphate. CO2: carbon dioxide. Enzyme names are in bold. LDH: lactate dehydrogenase. PFL: pyruvate formate lyase. PHDc: pyruvate dehydrogenase complex. PTA: phosphotransacetylase. ACK: acetate kinase.
Christian Solem (538116), Siu Hung Joshua Chan (538114), Peter Ruhdal Jensen (168177), Lasse Nørregaard (538115)   +3 more
core   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

3D-QSAR studies of pyruvate dehydrogenase kinase inhibitors based on a divide and conquer strategy

, 2004
PDHK is a highly specific enzyme, which inhibits PDC thereby reducing the conversion of pyruvate to AcetylCoA leading to increased glucose and lactate level contributing to various pathological disease states.
Bharatam, Prasad V., Sobhia, M.Elizabeth, Aboye, Teshome Leta   +2 more
core   +1 more source

Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia

Interdisciplinary Medicine, EarlyView.
For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang, Zihong Cai, Bingqing Tang, Zicong Huang, Baiwei Luo, Bingyu Lin, Yunong Yang, Zhihao Jin, Xiaoqing Li, Xiuli Xu, Yeling Deng, Chaoran Lin, Liang Wang, Hongsheng Zhou   +13 more
wiley   +1 more source

Characterization of human pyruvate dehydrogenase kinase isoform 2 (PDHK2 [PDF]

Doctor of PhilosophyDepartment of BiochemistryThomas E. RocheSpecific mutants were developed to evaluate the roles of several residues in [Alpha]8 helix of the regulatory (R) domain of human pyruvate dehydrogenase kinase 2 (PDHK2) in the linkage between ...
Hu, Liangyan
core  

Reconceptualizing Aplastic Anemia—Seed, Worm, Soil

Journal of Clinical Laboratory Analysis, EarlyView.
Aplastic anemia (AA) encompasses a group of hematological syndromes often misdiagnosed, resulting in a decrease in the overall blood cell count and representing a form of bone marrow failure. We reinterpret AA based on the “seed, worm, and soil” doctrine.
Xintong Xu, Zining Wang, Jiaming Hu, Chunyan Liu, Rong Fu   +4 more
wiley   +1 more source

TNFα increases the degradation of pyruvate dehydrogenase kinase 4 by the Lon protease to support proinflammatory genes. [PDF]

Proc Natl Acad Sci U S A, 2023
Boutagy NE, Fowler JW, Grabinska KA, Cardone R, Sun Q, Vazquez KR, Whalen MB, Zhu X, Chakraborty R, Martin KA, Simons M, Romanoski CE, Kibbey RG, Sessa WC.   +13 more
europepmc   +1 more source

Calcium, methyl jasmonate and their combined foliar applications: Influence on Tempranillo grape amino acids composition over two seasons

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Climate change is currently affecting chemical grape composition and, consequently, grape quality. The foliar application of biostimulants has emerged as a promising approach to mitigate these effects. This study investigated the effects of foliar applications of calcium (Ca), methyl jasmonate (MeJ), and their combination (Ca + MeJ)
Teresa Garde‐Cerdán, Eva P Pérez‐Álvarez, Itziar Sáenz de Urturi, Rebeca Murillo‐Peña, Lesly L Torres‐Díaz, Miriam González‐Lázaro   +5 more
wiley   +1 more source

Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk. [PDF]

Cardiovasc Res, 2023
Forteza MJ, Berg M, Edsfeldt A, Sun J, Baumgartner R, Kareinen I, Casagrande FB, Hedin U, Zhang S, Vuckovic I, Dzeja PP, Polyzos KA, Gisterå A, Trauelsen M, Schwartz TW, Dib L, Herrmann J, Monaco C, Matic L, Gonçalves I, Ketelhuth DFJ.   +20 more
europepmc   +1 more source

Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation

, 2015
Vascular calcification, a pathologic response to defective calcium and phosphate homeostasis, is strongly associated with cardiovascular mortality and morbidity.
Jeong, Ji Yun, Choi, Hueng-Sik, Do, Ji-Yeon, Wang, Yu, Harris, Robert A., Lee, Ki-Up, Kim, Han-Jong, Park, Keun-Gyu, Park, Sungmi, Ho Jeoung, Nam, Lee, In-Kyu, Kim, Joon-Young, Doo Kim, Nam, Go, Younghoon, Lee, Sun Joo, Oh, Chang Joo, Choi, Young-Keun, Ha, Chae-Myung, Huh, Seung, Choi, Je-Yong   +19 more
core   +1 more source