Pyruvate Dehydrogenase Kinase 1 inhibition mediated oxidative phosphorylation enhancement in cartilage promotes osteoarthritis progression [PDF]
BMC Musculoskeletal Disorders, 2023 Osteoarthritis (OA) is a common disease characterized by cartilage degradation. Growing evidence showed that glucose metabolism impacts joint homeostasis and an imbalance between glycolysis and oxidative phosphorylation (OXPHOS) may exacerbate OA ...
Xian Yang +8 more
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Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism [PDF]
Diabetes & Metabolism Journal, 2018 Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex
Sungmi Park +6 more
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Purification and partial characterization of rat liver pyruvate dehydrogenase kinase activator protein (free pyruvate dehydrogenase kinase) [PDF]
FEBS Letters, 1992 Rat liver pyruvate dehydrogenase (PDH) kinase activator protein (KAP), a free PDH kinase readily separable from PDH complex and its intrinsic kinase, has been purified to apparent homogeneity from liver mitochondria of fed and 48‐h starved rats. On SDS‐PAGE an apparently single band of M, 45 kDa was obtained.
Priestman, David A. +3 more
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Pyruvate dehydrogenase kinase regulates macrophage polarization in metabolic and inflammatory diseases. [PDF]
Front Immunol, 2023 Macrophages are highly heterogeneous and plastic, and have two main polarized phenotypes that are determined by their microenvironment, namely pro- and anti-inflammatory macrophages.
Li C +6 more
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Neoplasia: An International Journal for Oncology Research, 2005 Pyruvate dehydrogenase (PDH) catalyzes the conversion of pyruvate to acetyl-coenzyme A, which enters into the Krebs cycle, providing adenosine triphosphate (ATP) to the cell.
Michael I. Koukourakis +4 more
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Essential role of coenzyme A in pyruvate dehydrogenase kinase activity
FEBS Letters, 1982 The rate of phosphorylation and concomitant inactivation of purified pig heart muscle pyruvate dehydrogenase complex by intrinsic kinase (EC 2.7.1.99) is markedly accelerated by the addition of coenzyme A to the incubation medium, showing a half‐maximum effect at 1.8 μM. The pantetheine moiety is the effective part of the coenzyme A molecule.
Siess, E.A., Weiland, O.H.
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Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation [PDF]
Cell Reports, 2023 Summary: Activating the macrophage NLRP3 inflammasome can promote excessive inflammation with severe cell and tissue damage and organ dysfunction.
Allison K. Meyers +17 more
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Effects of aerobic training on pyruvate dehydrogenase and pyruvate dehydrogenase kinase in human skeletal muscle [PDF]
The Journal of Physiology, 2004 This study examined the effects of short‐ and long‐term aerobic training on the stable up‐regulation of pyruvate dehydrogenase (PDH) and PDH kinase (PDK) in human skeletal muscle. We hypothesized that 8 weeks, but not 1 week, of aerobic training would increase total PDH (PDHt) and PDK activities compared to pretraining, and this would be detectable at ...
Paul J, LeBlanc +4 more
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Pyruvate dehydrogenase kinase activity of pig heart pyruvate dehydrogenase (E1 component of pyruvate dehydrogenase complex) [PDF]
Biochemical Journal, 1985 The pyruvate dehydrogenase (E1) and acetyltransferase (E2) components of pig heart and ox kidney pyruvate dehydrogenase (PDH) complex were separated and purified. The E1 component was phosphorylated (alpha-chain) and inactivated by MgATP. Phosphorylation was mainly confined to site 1.
A L, Kerbey, P J, Randle
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Food Production, Processing and Nutrition, 2020 Pyruvate dehydrogenase kinase (PDK) is a mitochondrial enzyme in a variety of eukaryotes, including the plant pathogen Fusarium graminearum. This enzyme can reduce the oxidation of glucose to acetyl-coA by phosphorylation and selectively inhibits the ...
Tao Gao +5 more
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