Results 251 to 260 of about 80,914 (291)
The FASEB Journal, Volume 40, Issue 12, 30 June 2026.Under normal conditions, RagD and mTORC1 respond to amino acid changes. Upon stimulation, active mTORC1 phosphorylates S6K, 4E‐BP1, and TFEB. In response to starvation, mTORC1 is inactive. Our data indicate that the RRAGD p.(Ser76Leu) variant maintains the phosphorylation of mTORC1 targets during starvation in T‐REx HeLa cells.
Anastasia Adella +11 more
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S100A4 Orchestrates Fibroblast Fate to Drive Fibrotic Remodeling
The FASEB Journal, Volume 40, Issue 12, 30 June 2026.Fibrotic stimuli induce S100A4 expression, promoting the activation of apoptosis‐resistant fibroblasts through engagement of ERK‐associated signaling. In fibroblasts, S100A4 orchestrates fibroblast fate by enhancing migration, promoting stress fiber formation, increasing ECM contractility, upregulating α‐SMA expression, and supporting survival ...
Spring Li +6 more
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The Antidepressant Drug Clomipramine Inhibits the ABC Transporter BmrA
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Drug uptake is constrained by epithelial barriers, such as the intestine and the blood–brain barrier, which express efflux pumps such as the ABC‐transporter ABCB1. Therefore, drugs targeting the central nervous system frequently require co‐administration of efflux inhibitors to facilitate sufficient target engagement. Conversely, certain drugs designed
Nadja Hellmann +3 more
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A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
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Biochemical and Biophysical Research Communications, 1977
Abstract Evidence is presented that phosphopeptides produced by tryptic digestion of phosphorylated pyruvate dehydrogenase are effective substrates for pyruvate dehydrogenase phosphatase and that the dephosphopeptides can serve as substrates for pyruvate dehydrogenase kinase.
Flora H Pettit +2 more
exaly +3 more sources
Abstract Evidence is presented that phosphopeptides produced by tryptic digestion of phosphorylated pyruvate dehydrogenase are effective substrates for pyruvate dehydrogenase phosphatase and that the dephosphopeptides can serve as substrates for pyruvate dehydrogenase kinase.
Flora H Pettit +2 more
exaly +3 more sources
Increased pyruvate dehydrogenase kinase activity in response to sepsis
American Journal of Physiology-Endocrinology and Metabolism, 1991 The effect of sterile inflammation and sepsis on the proportion of active pyruvate dehydrogenase complex (PDH) in mitochondria isolated from skeletal muscle has been investigated. The proportion of active PDH in mitochondria isolated from septic animals was significantly reduced compared with control under all incubation conditions examined, even in ...
T. C. Vary
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FEBS Letters, 1984 Extracts of heart mitochondria from fed and from 48 h starved rats subjected to gel filtration on Sephacryl S-300 gave 4 major protein peaks. Pyruvate dehydrogenase complex eluted in the void volume and was assayed for intrinsic pyruvate dehydrogenase ...
Alan L Kerbey, P J Randle, A L Kerbey
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Effects of pyruvate on pyruvate dehydrogenase kinase of rat heart
Molecular and Cellular Biochemistry, 1995Sensitivity of rat heart pyruvate dehydrogenase kinase (PDHK) to pyruvate inhibition was tested under various conditions using pyruvate dehydrogenase complex (PDC) in mitochondria (mPDC) and in a high speed precipitate of whole tissue homogenates (hPDC).
T C, Carter, H G, Coore
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Pyruvate inhibition of pyruvate dehydrogenase kinase is a physiological variable
Biochemical and Biophysical Research Communications, 1985Pyruvate inhibited pyruvate dehydrogenase kinase activity in mitochondria from adipose tissue, heart, brain and kidney of fed rats. Starvation for 24 h led to increased kinase activity in mitochondria from adipose tissue and heart but not from brain or kidney and to reduction of pyruvate inhibition of the enzyme from adipose tissue, heart and brain ...
D, Lyn, H G, Coore
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Archives of Biochemistry and Biophysics, 1985
The specificities of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase were probed using synthetic peptides corresponding to the sequence around phosphorylation sites 1 and 2 on pyruvate dehydrogenase [Tyr-His-Gly-His-Ser(P1)-Met-Ser-Asp-Pro-Gly-Val-Ser(P2)-Tyr-Arg].
T R, Mullinax +3 more
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The specificities of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase were probed using synthetic peptides corresponding to the sequence around phosphorylation sites 1 and 2 on pyruvate dehydrogenase [Tyr-His-Gly-His-Ser(P1)-Met-Ser-Asp-Pro-Gly-Val-Ser(P2)-Tyr-Arg].
T R, Mullinax +3 more
openaire +2 more sources