Results 171 to 180 of about 149,531 (302)

Cuproptosis‐Related Genes in Immune Infiltration and Diagnosis in Hepatitis B Virus‐Related Acute Liver Failure

Exploration, EarlyView.
The role of cuproptosis in HBV‐ALF was explored via bioinformatics and liver biopsy tissues. There are some crosstalks among cuproptosis, immune infiltration, and ferroptosis (The figure was created by Bio Render). ABSTRACT Hepatitis B virus (HBV) infection poses a significant challenge to global health, particularly in developing countries such as ...
Jingwen Deng, Tao Zhu, Yueyang Wang, Sitong Zhang, Hong Deng, Guilan Quan, Tingting Peng, Chuanbin Wu, Huiqiang Cai, Chao Lu, Xiaopeng Cai   +10 more
wiley   +1 more source

Pyruvate kinase and its inhibition by L-alanine: clinical importance in human brain tumours

, 1997
We studied pyruvate kinase activity and its inhibition by alanine in 33 human brain tumours and nine normal adult blain tissues. With the exception of two schwannomas, there were no significant differences between the specific pyruvate kinase activities ...
Ulakoglu, EZ, Sonmez, H, Sandikci, KS, Tuter, Y, Kokoglu, E, Ozyurt, E   +5 more
core  

Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis

Exploration, EarlyView.
Smart nanodelivery systems deliver therapeutic payloads across the cartilage matrix to ensure their sustained accumulation within chondrocytes at sites of injury. By targeting specific molecular targets and signaling pathways, these platforms modulate the pathological synovium‐cartilage axis to restore immunometabolic homeostasis and drive tissue ...
Qirui Zhao, Zhewen Mi, Shuya Liu, Shijun Liang, Linjia Peng, Zixuan Gao, Jiaming Li, Xiaoqing Lu, Zhiguang Ren, Yongjie Wan, Shengsheng Cui, Longlong Lu, Xiaoyang Gao, Tao Wang, Hui Liang, Furong Tian, de la Fuente Jesus M, Chong Xiang, Luyi Sun, Lichen Xiang, Daxiang Cui   +20 more
wiley   +1 more source

The pyruvate kinase activator etavopivat (FT-4202) limits pulmonary and systemic sequelae of sepsis in a mouse LPS model. [PDF]

Am J Physiol Lung Cell Mol Physiol
Chen Y, Zhu H, Zhang L, Mai W, Chow SC, Chin DWL, Guichard S, Carden M, Jagadish A, Estupinan RA, Welsby I, McMahon TJ.   +11 more
europepmc   +1 more source

Myeloid Mas drives pyruvate kinase M2-mediated Spi1 lactylation to fuel inflammatory senescence in MASLD. [PDF]

Signal Transduct Target Ther
Zhao L, Xu S, Qiao S, Wang Z, Wang S, Liu C, Zhang S, Wang P, Sun X, Li S, Chen L, Zhang X, Hu C, Zhou Y, Xia L, Yang C, Li J.   +16 more
europepmc   +1 more source

Nuclear translocation of pyruvate kinase M2 drives high glucose-induced angiogenesis in retinal endothelial cells <i>via</i> the HIF-1α axis. [PDF]

Int J Ophthalmol
Liu TY, Tian YJ, Kuai PZ, Luo YS, Duan CW, Chen TP, Wang XL, Zhang DM, Cao X.   +8 more
europepmc   +1 more source

Neonatal Pyruvate Kinase Deficiency Presenting with Severe Hemolytic Anemia and Liver Failure. [PDF]

Children (Basel)
Hsu YH, Jiang CB, Hou JY, Jim WT, Lin SP, Chang SW, Tseng KT, Lee NC.   +7 more
europepmc   +1 more source

Pyruvate Kinase

Journal of Biological Chemistry, 1962
Daniel V. Kimberg, K. Lemone Yielding
openaire   +1 more source

Pyruvate kinase deficiency modifies sickle hemoglobin carrier and sickle cell disease phenotypes in mice. [PDF]

JCI Insight
Wang X, Smith M, Kamimura S, Li Q, Shah N, Quezado M, Almeida LE, Vogel S, Tegegn MB, Sun KY, Villasmil R, Liu C, Eaton WA, Thein SL, Quezado ZM.   +14 more
europepmc   +1 more source

Immunoassay for pyruvate kinase M1/2 as an Alzheimer's biomarker in CSF. [PDF]

Open Life Sci
de Geus MB, Kivisäkk P, Trombetta BA, Tijms BM, Visser PJ, Arnold SE, Carlyle BC.   +6 more
europepmc   +1 more source