Results 191 to 200 of about 1,722,299 (336)

Pyruvate kinase M2 is elevated in systemic sclerosis and plays a role in its pathogenesis. [PDF]

Front Immunol
Steadman T, O'Reilly S.
europepmc   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Mechanistic study of chenodeoxycholic acid targeting pyruvate kinase to regulate hepatic lipid metabolism. [PDF]

Biomed Rep
Zhang X, Tan S, Zhou X.
europepmc   +1 more source

Mac‐2 Binding Protein Glycosylation Isomer (M2BPGi)–Based Risk Stratification Refined by Tumor Metabolic Activity in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
M2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Kojiro Shirabe, Junya Mita, Shinji Itoh, Takeo Toshima, Yoshiyuki Kitamura, Norifumi Iseda, Takuro Isoda, Kousei Ishigami, Tomoharu Yoshizumi   +8 more
wiley   +1 more source

From structural insight to molecule: Integrative molecular simulations identify candidate pyruvate kinase activators. [PDF]

PLoS One
Dermawan D, Alotaiq N.
europepmc   +1 more source

Global research landscape and thematic transitions in pyruvate kinase deficiency: a decadal bibliometric analysis (2015-2025). [PDF]

Front Med (Lausanne)
Zhao W, Wang Y, Gao N, Yu W, Liu Z.
europepmc   +1 more source

Host‐Specific Interactions Between Staphylococcus aureus and Pseudomonas aeruginosa Impair Epithelial Repair in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is frequently associated with polymicrobial biofilms involving Staphylococcus aureus and Pseudomonas aeruginosa. Interactions between these organisms are thought to influence disease severity, but the epithelial effects of exoproteins derived from patient‐matched cocultures remain poorly defined ...
Xiaohan Sun, Mahnaz Ramezanpour, George Bouras, Emma Barry, Alkis J. Psaltis, Peter‐John Wormald, Sarah Vreugde   +6 more
wiley   +1 more source

Pyruvate kinase M2 in Alzheimer's disease: from dysregulation to therapeutic inhibition. [PDF]

Brain Commun
Gojani EG, Sutherland RJ, Mohajerani MH.
europepmc   +1 more source

Measurement of metabolic fluxes through pyruvate kinase, phosphoenolpyruvate carboxykinase, pyruvate dehydrogenase, and pyruvate carboxylase in hepatocytes of different acinar origin

, 1996
Isolated hepatocytes were prepared from the periportal and perivenous regions of the liver of 18-h-starved rats. These showed characteristic enzyme patterns and an enhanced rate of ureagenesis in the periportal cells; however, total cellular ATP content ...
Michael Titheradge (4460512), Claire G Jones (16071443)   +1 more
core  

Unveiling the inhibitory effects of tannic acid and doxorubicin combination on pyruvate kinase M2 in breast cancer cells. [PDF]

Front Pharmacol
Wang Y, El-Far A, Warda AA, Mohamed SA, Maghsoudloo M, Hashim PK, Elewa YHA, Elmetwalli A, Al Jaouni SK, Zhao W.   +9 more
europepmc   +1 more source