Results 211 to 220 of about 149,531 (302)

Pyruvate Kinase Deficiency: Markedly Decreased Reticulocyte PK Activity and Limited Specificity of the PK/HK Ratio. [PDF]

Int J Mol Sci
Koleva L, Dolgikh IA, Kryukova AV, Prudinnik DS, Bovt EA, Shakhidzhanov SS, Mann SG, Smetanina NS, Ataullakhanov FI, Sinauridze EI.   +9 more
europepmc   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Precise metabolomics identifies glycolysis-related pyruvate kinase M activity as regulator of the S-phase-specific radiation response in triple-negative breast cancer cells. [PDF]

Cell Commun Signal
Matesanz-Sánchez R, Classen S, Siniuk K, Peitzsch M, Alves T, Pospiech H, Borgmann K, Cordes N.   +7 more
europepmc   +1 more source

Proteomic Profiling of Primary Hippocampal Neurons Reveals Noncanonical GFAP Expression and Metabolic Adaptations in Glia‐Free Culture

PROTEOMICS, EarlyView.
ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz, Kinga Gostomska‐Pampuch, Natalia Pudełko‐Malik, Mariusz Fleszar, Agnieszka Gizak, Jacek R. Wiśniewski, Dariusz Rakus   +6 more
wiley   +1 more source

Overall Survival of Patients With Pyruvate Kinase Deficiency in the UK: A Real-World Study. [PDF]

EJHaem
Foy P, Higa S, Zhao J, Keapoletswe K, Cirneanu L, Venerus A, Raiteri L, Landfeldt E, Iob E, Lombard L, Li J, Zagadailov E.   +11 more
europepmc   +1 more source

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

Genome-Wide Identification and Expression Profiling of Pyruvate Kinase Genes in Litchi Under Calcium-Magnesium Foliar Treatment. [PDF]

Plants (Basel)
Sajjad M, Jiao J, Tahir H, Wei L, Ma W, Zeeshan Ul Haq M, Farooq MA, Zhou K.   +7 more
europepmc   +1 more source

Analysis of glutamine synthetase target‐site mutations and their role in endowing glufosinate‐ammonium resistance

Pest Management Science, EarlyView.
GS2.2 G255D mutation conferred enzyme‐level glufosinate insensitivity but no whole‐plant resistance, showing trade‐offs between catalytic function and herbicide binding and providing a baseline for future studies on target‐site glufosinate resistance.
Aimone Porri, Susee Sudhakar, Matheus M Noguera, Michael Betz, Jens Lerchl, Franck E Dayan, Ingo Meiners, Tino Caldarelli, Jason Norsworthy   +8 more
wiley   +1 more source

Transcriptomic analysis reveals that pyruvate kinase potentially plays a key role in the differentiation of Spirometra mansoni proglottids by regulating the glycolysis pathway. [PDF]

PLoS Negl Trop Dis
Zhou K, Cao CY, Ru SS, Wang RJ, Hao J, Zhang X.   +5 more
europepmc   +1 more source

DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity

Small, EarlyView.
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley   +1 more source