Results 221 to 230 of about 1,722,299 (336)

Impact of Agitation Power Input on Aspergillus oryzae Metabolism: Application of Multi‐Omics on an Industrial Enzyme Fermentation

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The agitation power input substantially impacts the oxygen transfer rate in aerobic fermentation processes. Furthermore, in a carbon‐limited process where the substrate feed rate is controlled by the concentration of dissolved oxygen, the power input will consequently govern the feed rate.
Mariana Albino, Jean‐Marie Mouillon, Gisela Nadal‐Rey, Carina L. Gargalo, Ulrich Krühne, Krist V. Gernaey, Mads O. Albæk   +6 more
wiley   +1 more source

Expanding the PKLR mutation spectrum: discovery of two novel variants in two pediatric cases of pyruvate kinase deficiency. [PDF]

Ann Hematol
Sakalian O, Huguenin Y, Pissard S, Augis V, Weinmann L, Fuster V, Lagarde M, Badour E, Aladjidi N, Boutin J, Dulucq S.   +10 more
europepmc   +1 more source

Species Dynamics and Gene Expression in Algal Polycultures Under Mixotrophic Cultivation in Outdoor Pilot‐Scale Nordic Conditions

Biotechnology and Bioengineering, EarlyView.
These results demonstrate that mixotrophic conditions drive both microbial community shifts and metabolic reprogramming, underscoring the importance of cultivation strategy and polyculture selection for targeted applications such as nutrient recovery and bioproduct generation.
Quyen Nham, Hanna Farnelid, Catherine Legrand, Elin Lindehoff   +3 more
wiley   +1 more source

The pyruvate kinase activator etavopivat (FT-4202) limits pulmonary and systemic sequelae of sepsis in a mouse LPS model. [PDF]

Am J Physiol Lung Cell Mol Physiol
Chen Y, Zhu H, Zhang L, Mai W, Chow SC, Chin DWL, Guichard S, Carden M, Jagadish A, Estupinan RA, Welsby I, McMahon TJ.   +11 more
europepmc   +1 more source

Isolation and Characterization of Random Citrate Synthase Variants That Increase Acetate Generation by Escherichia coli

Biotechnology and Bioengineering, EarlyView.
ABSTRACT A method to select Escherichia coli citrate synthase variants having reduced activity was developed based initially on the increased generation of acid, observed visually by prolonged color change in the pH indicator bromocresol purple. Five hundred fifty‐two potential variants were isolated and each were cultured on glucose as sole carbon ...
Jeffrey K. Dodelin, Ronnie L. Fulton, Abigail E. Rose, Mark A. Eiteman   +3 more
wiley   +1 more source

Myeloid Mas drives pyruvate kinase M2-mediated Spi1 lactylation to fuel inflammatory senescence in MASLD. [PDF]

Signal Transduct Target Ther
Zhao L, Xu S, Qiao S, Wang Z, Wang S, Liu C, Zhang S, Wang P, Sun X, Li S, Chen L, Zhang X, Hu C, Zhou Y, Xia L, Yang C, Li J.   +16 more
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Neonatal Pyruvate Kinase Deficiency Presenting with Severe Hemolytic Anemia and Liver Failure. [PDF]

Children (Basel)
Hsu YH, Jiang CB, Hou JY, Jim WT, Lin SP, Chang SW, Tseng KT, Lee NC.   +7 more
europepmc   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Immunoassay for pyruvate kinase M1/2 as an Alzheimer's biomarker in CSF. [PDF]

Open Life Sci
de Geus MB, Kivisäkk P, Trombetta BA, Tijms BM, Visser PJ, Arnold SE, Carlyle BC.   +6 more
europepmc   +1 more source