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Relaxation spectra of pyruvate kinase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1970Relaxation studies using the temperature jump have been carried out on pyruvate kinase (ATP: pyruvate phosphotransferase, EC 2.7.1.40) isolated from rabbit muscle. Several concentration-independent relaxation effects with associated relaxation times of approx.
Gordon G. Hammes, Jon Simplicio
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2021
Pyruvate kinase is an important enzyme of glycolytic pathway that catalyzes the last step of this pathway. In human erythrocytes, there is no mitochondrion hence glycolytic pathway is the most important source of energy generation. In vitro, in vivo, and case control studies suggested that pyruvate kinase deficiency provides resistance against P ...
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Pyruvate kinase is an important enzyme of glycolytic pathway that catalyzes the last step of this pathway. In human erythrocytes, there is no mitochondrion hence glycolytic pathway is the most important source of energy generation. In vitro, in vivo, and case control studies suggested that pyruvate kinase deficiency provides resistance against P ...
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Pyruvate Kinase Deficiency and Malaria
New England Journal of Medicine, 2008Malaria that is caused by Plasmodium falciparum is a significant global health problem. Genetic characteristics of the host influence the severity of disease and the ultimate outcome of infection, and there is evidence of coevolution of the plasmodium parasite with its host.
Melanie Kirby-Allen +7 more
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The Regulation of Pyruvate Kinase
1971Publisher Summary This chapter discusses the molecular and kinetic properties, and the physiological significance of pyruvate kinase. From a thermodynamic consideration, these enzymes are especially suited for a control of glycolysis, because they catalyze unidirectional steps driving the metabolic flux into one direction.
Werner Seubert, Wilhelm Schoner
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Turnover of liver pyruvate kinase
Archives of Biochemistry and Biophysics, 1980Abstract The relative rates of synthesis and degradation for liver pyruvate kinase have been determined in rats fed standard lab chow, fasted, and refed a high-carbohydrate-low-protein diet. Relative rates of synthesis and apparent rates of degradation were determined by pulse-labeling the enzyme in vivo with l -[4,5- 3 H]leucine and by measuring ...
G. Larry Cottam, Christos Cladaras
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Insulin: Inducer of Pyruvate Kinase
Science, 1965The hepatic pyruvate kinase activity markedly decreased when rats were made diabetic by alloxan injection. Insulin treatment induced new synthesis of pyruvate kinase which was prevented by injection of ethionine and actinomycin D. The evidence indicated that the increased pyruvate kinase activity induced by insulin entails at a certain stage a ...
George Weber +2 more
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1987
Publisher Summary The chapter discusses the regulatory phosphorylation of pyruvate kinase type L by cAMP-dependent protein kinase. It also briefly discusses the role of phosphorylation of liver pyruvate kinase in the regulation of glycolysis and gluconeogenesis.
Lorentz Engström +3 more
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Publisher Summary The chapter discusses the regulatory phosphorylation of pyruvate kinase type L by cAMP-dependent protein kinase. It also briefly discusses the role of phosphorylation of liver pyruvate kinase in the regulation of glycolysis and gluconeogenesis.
Lorentz Engström +3 more
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Effects of pyruvate on pyruvate dehydrogenase kinase of rat heart
Molecular and Cellular Biochemistry, 1995Sensitivity of rat heart pyruvate dehydrogenase kinase (PDHK) to pyruvate inhibition was tested under various conditions using pyruvate dehydrogenase complex (PDC) in mitochondria (mPDC) and in a high speed precipitate of whole tissue homogenates (hPDC).
Haldane G. Coore, Tonia C. Carter
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Pyruvate kinase of Brevibacterium liquefaciens
Archives of Biochemistry and Biophysics, 1970Abstract Pyruvate kinase was purified 270-fold from an extract of Brevibacterium liquefaciens and its regulatory properties were examined. The purified enzyme existed as an almost inactive form. Preincubation with ATP, NaCl, or with KCl caused marked activation of the enzyme, although these compounds were inhibitory if added during the reaction.
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Pyruvate Kinase Deficiency [PDF]
, 1978 Hereditary nonspherocytic hemolytic anemia is a relatively recently recognized entity. It was first discussed in detail by Dacie et al, in 1953,1 and by 1960 over 60 cases had been reported.2 Motulsky et al.3 noted increased 2,3-DPG levels in several patients with hereditary nonspherocytic hemolytic anemia.
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