Results 91 to 100 of about 51,864 (248)

Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells

Cancer & Metabolism, 2019
Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic cancer remains controversial.
Lei Yu, Shao Thing Teoh, Elliot Ensink, Martin P. Ogrodzinski, Che Yang, Ana I. Vazquez, Sophia Y. Lunt   +6 more
doaj   +1 more source

Role of pyruvate kinase M20-regulated glycolysis in inflammatory activation of macrophages in diabetic nephropathy

Di-san junyi daxue xuebao, 2020
Objective To explore the role of pyruvate kinase M20 (PKM2)-regulated glycolysis on nod-like receptor protein 3 (NLRP3)- and absentin melanoma 2 (AIM2)-mediated inflammatory activation of macrophages in diabetic nephropathy (DN).
XIE Shan, XU Xingxin
doaj   +1 more source

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. [PDF]

, 2012
The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose ...
Graeber, Thomas G, Graham, Nicholas A, Kohli, Bitika, Komisopoulou, Evangelia, Lo, Roger S, Mellinghoff, Ingo K, Mischel, Paul S, Ribas, Antoni, Tahmasian, Martik, Teitell, Michael A, Vivanco, Igor, Wu, Hong, Zhu, Maggie   +12 more
core  

Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome [PDF]

, 2008
OBJECTIVE: Features of the metabolic syndrome such as central obesity with insulin resistance and dyslipidemia are typical signs of Cushing's syndrome and common side effects of prolonged glucocorticoid treatment.
Blerina Kola, Mirjam Christ-Crain, Francesca Lolli, Giorgio Arnaldi, Gilberta Giacchetti, Marco Boscaro, Ashley B. Grossman, Márta Korbonits, Kola, Gudbjornsson, van Staa, Walsh, Arnaldi, Mayo-Smith, Kahn, Christ-Crain, Tataranni, Steinberg, Hojlund, Bandyopadhyay, Kola, Hawley, Terzolo, Mantero, Barzon, Bujalska, Seckl, Daval, Wang, Vander Kooi, Shaw, Clark   +31 more
core   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

HBV-Induced Pyruvate Increases Lactylation of Pyruvate Kinase M2 (PKM2) at K206 to Promote Liver Fibrosis

Pathogens
We previously demonstrated that HBV promotes liver fibrosis through the enhanced production of pyruvate. Pyruvate kinase M2 (PKM2), a key enzyme in pyruvate metabolism, plays an important role in liver fibrogenesis. Recently, lactylation of PKM2 has been
Wenxian Wen, Qin Du, Shuhan Li, Youmin Yang, Xianding Wang, Shasha Li, Yujia Li, Shilin Li, Chunhui Yang, He Xie, Xiaoqiong Duan, Limin Chen   +11 more
doaj   +1 more source

Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells

Nature Communications, 2018
The glycolytic enzyme pyruvate kinase M2 (PKM2) is required for nucleotide synthesis and cell proliferation. Using gene expression and metabolomics analyses, the authors here show that PKM2 regulates methionine metabolism and DNA methylation in ...
Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, Stefan Günther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente, Didier Y. R. Stainier   +15 more
doaj   +1 more source

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis [PDF]

, 2014
Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer.
Anastasiou, Dimitrios, Asara, John M., Auld, Douglas S., Austin, Christopher P., Boxer, Matthew B., Brimacombe, Kyle R., Cantley, Lewis C., Christofk, Heather R., Courtney, Kevin D., Dang, Lenny, Davidson, Shawn M., Dimov, Svetoslav, Fiske, Brian P., Harris, Marian H., Hong, Bum Soo, Inglese, James, Israelsen, William J., Jha, Abhishek, Jiang, Jian-kang, Jin, Shengfang, Johnson, Zachary R., Khan, Tahsin M., Kung, Charles, Kunii, Kaiko, Leister, William, Lunt, Sophia Y., Malstrom, Scott, Mattaini, Katherine R., Metallo, Christian M., Park, Hee-Won, Salituro, Francesco G., Shen, Min, Skoumbourdis, Amanda P., Southall, Noel, Stephanopoulos, Gregory, Tempel, Wolfram, Thomas, Craig J., Vander Heiden, Matthew G., Veith, Henrike, Walsh, Martin J., Yang, Hua, Yen, Katharine E., Yu, Yimin   +42 more
core   +1 more source

Blood Lactate as a Prognostic Biomarker for Survival and Weight Loss in Amyotrophic Lateral Sclerosis: An Exploratory–Validation Study

Annals of Neurology, EarlyView.
Objective Lactate is increasingly recognized as an energy substrate, but its relevance to amyotrophic lateral sclerosis (ALS) remains unclear. We examined whether blood lactate is associated with survival and weight loss in ALS. Methods This retrospective study included an Australian exploratory cohort and a Japanese validation cohort with clinical ...
Ryutaro Nakamura, Frederik J. Steyn, Shuhei Kobashi, Nobuhiro Ogawa, Akihiro Kitamura, Isamu Yamakawa, Robert D. Henderson, Shyuan T. Ngo, Makoto Urushitani   +8 more
wiley   +1 more source

Research progress of PKM2-mediated regulatory pathways in periodontitis [PDF]

Kouqiang yixue
Enhanced glycolysis and other host metabolic reprogramming are recognized as core drivers of sustained inflammation. As a rate-limiting enzyme of glycolysis, the pyruvate kinase M2 (PKM2) exerts important effects on various chronic inflammatory diseases ...
GAO Han, ZHOU Yue
doaj   +1 more source