Protective Effects of Pyruvic Acid Salt Against Lithium Toxicity and Oxidative Damage in Human Blood Mononuclear Cells [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: Aim of present work was to study cytoprotective properties of lithium pyruvate, as a prospective pharmacological agent. Pyruvate has a lot of potential benefits due to positive influence on cell metabolism.
Evgenii Plotnikov +3 more
doaj +1 more source
LC-MS proteomics analysis of the iInsulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism [PDF]
, 2014 The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression ...
Braeckman, Bart +7 more
core +2 more sources
SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα
Cell Reports, 2019 Summary: The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling, known to regulate multiple metabolic pathways. SIRT6 binds PPARα and its
Shoshana Naiman +20 more
doaj +1 more source
Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex
Nature Communications, 2020 The pyruvate dehydrogenase complex (PDC) is a multienzyme complex connecting glycolysis to mitochondrial oxidation of pyruvate. Cryo-EM analysis of PDC from Neurospora crassa reveals localization of fungi-specific protein X (PX) and confirms that it ...
B. O. Forsberg +4 more
doaj +1 more source
Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi. [PDF]
, 2014 The acetyl-CoA "Wood-Ljungdahl" pathway couples the folate-mediated one-carbon (C1) metabolism to either CO2 reduction or acetate oxidation via acetyl-CoA.
Alvarez-Cohen, Lisa +8 more
core +1 more source
Біологічні студії, 2015 The dependence of permeabilized rat hepatocytes respiration rate on oxidation substrates concentration at presence 0.1 and 1 µM Са2+ in the medium and amino sulfonic acid – taurine – effect on this subordination was studied.
V. M. Merlavsky +3 more
doaj +1 more source
Potential therapeutic use of the ketogenic diet in autism spectrum disorders. [PDF]
, 2014 The ketogenic diet (KGD) has been recognized as an effective treatment for individuals with glucose transporter 1 (GLUT1) and pyruvate dehydrogenase (PDH) deficiencies as well as with epilepsy.
Dueñas, Nadia +2 more
core +1 more source
Kruppel‐like factor 15 regulates fuel switching between glucose and fatty acids in brown adipocytes
Journal of Diabetes Investigation, 2021 Aims/Introduction Brown adipose tissue (BAT) utilizes large amounts of fuel for thermogenesis, but the mechanism by which fuel substrates are switched in response to changes in energy status is poorly understood.
Yuko Nabatame +10 more
doaj +1 more source
BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei [PDF]
, 2014 While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.
Barrett, Michael P. +11 more
core +1 more source
A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]
, 2015 Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum +5 more
core +2 more sources