Results 71 to 80 of about 164,294 (288)

Effects of epinephrine on glucose transport and metabolism in adipose tissue of normal and hypothyroid rats

Journal of Lipid Research, 1968
Epinephrine increases the oxidation of glucose in adipose tissue even when its lipolytic effects are markedly reduced or abolished by propranolol, nicotinic acid, ouabain, or thyroidectomy.
George A. Bray, H.M. Goodman
doaj   +1 more source

Thyroid hormone reverses aging-induced myocardial fatty acid oxidation defects and improves the response to acutely increased afterload. [PDF]

PLoS ONE, 2013
Subclinical hypothyroidism occurs during aging in humans and mice and may contribute to the development of heart failure. Aging also impairs myocardial fatty acid oxidation, causing increased reliance on flux through pyruvate dehydrogenase (PDH) to ...
Dolena Ledee, Michael A Portman, Masaki Kajimoto, Nancy Isern, Aaron K Olson   +4 more
doaj   +1 more source

Minimizing acetate formation in E. coli fermentations [PDF]

, 2007
Escherichia coli remains the best established production organisms in industrial biotechnology. However, during aerobic fermentation runs at high growth rates, considerable amounts of acetate are accumulated as by-product.
De Maeseneire, Sofie, De Mey, Marjan, Soetaert, Wim, Vandamme, Erick   +3 more
core   +2 more sources

Self‐Feeding of Engineered Tissues via Controlled Glucose Release Facilitates Survival and Vascularization of Living Implants

Advanced Functional Materials, EarlyView.
ABSTRACT Engineering living matter has great clinical potential to deliver functional replacement organs. However, clinical translation remains hampered by the current inability to maintain viability of clinically relevant‐sized constructs. During the pre‐vascular phase, implants rely on nutrient diffusion for survival, which is insufficient at ...
Melvin Gurian, Iris E. Allijn, Laura Veenendaal, Nicole Bassous, Su Ryon Shin, Jeroen Leijten   +5 more
wiley   +1 more source

SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts

The Journal of Clinical Investigation
Previous studies highlight the potential for sodium-glucose cotransporter type 2 (SGLT2) inhibitors (SGLT2i) to exert cardioprotective effects in heart failure by increasing plasma ketones and shifting myocardial fuel utilization toward ketone oxidation.
Leigh Goedeke, Yina Ma, Rafael C. Gaspar, Ali Nasiri, Jieun Lee, Dongyan Zhang, Katrine Douglas Galsgaard, Xiaoyue Hu, Jiasheng Zhang, Nicole Guerrera, Xiruo Li, Traci LaMoia, Brandon T. Hubbard, Sofie Haedersdal, Xiaohong Wu, John Stack, Sylvie Dufour, Gina Marie Butrico, Mario Kahn, Rachel J. Perry, Gary W. Cline, Lawrence H. Young, Gerald I. Shulman   +22 more
doaj   +1 more source

Formate Excretion in Urine of Rats Fed Dimethylaminoazobenzene-rich Diets: The Possibility of Formate Formation from D-Lactate [PDF]

, 2008
This experiment was carried out to evaluate the possibility of degradation of d-lactate into formate and acetaldehyde. In order to induce hyperproduction of d-lactate in rats.
Kawase, Michi, Kitamura, Yuki, Ohmori, Shinji   +2 more
core   +1 more source

Diels‐Alder Click Chemistry as a Dynamic‐Covalent Crosslinking Method in Spheroid‐Encapsulating Hydrogels for Cartilage Engineering

Advanced Healthcare Materials, EarlyView.
This research shows the development of hydrogels with Diels‐Alder click chemistry for engineering cartilage‐like tissue. The hydrogels support cartilage spheroids which could be cultured for at least 28 days. Furthermore, the spheroids showed a tendency to fuse together into a more consistent construct, and produced important components needed for ...
Sanne M. van de Looij, Antonia G. Vasilopoulou, Lennard Spauwen, Antoinette van den Dikkenberg, Jasmijn V. Korpershoek, Mylene de Ruijter, Jos Malda, Bas G. P. van Ravensteijn, Tina Vermonden   +8 more
wiley   +1 more source

ECMO for Metabolic Crisis in a Patient with Mitochondrial Disease

Case Reports in Anesthesiology, 2021
Patients with mitochondrial disease exhibit disrupted pyruvate oxidation, resulting in intraoperative and perioperative physiologic derangements. Increased enzymatic conversion of pyruvate via lactate dehydrogenase during periods of fasting or stress can
Sonal Sharma, Clifford Deerman, Michael H. Andreae, Conrad Myler   +3 more
doaj   +1 more source

Directional Liquid Transport Enabled pH‐Responsive Hierarchical Composite for Enhanced Wound Healing

Advanced Healthcare Materials, EarlyView.
A hierarchical composite with a gradient architecture transitioning from hydrophobic to hydrophilic layers integrates diode‐like liquid transport, efficient water absorption, breathability, and mechanical robustness. This device enables a multifunctional therapeutic platform with pH‐responsive dual‐drug release, providing synergistic anti‐inflammatory ...
Baolin Wang, Li‐Fang Zhu, Yuna Lang, Siyi Zhang, Fei Chen, Ming‐Wei Chang   +5 more
wiley   +1 more source

Unraveling mitochondrial pyruvate dysfunction to mitigate hyperlactatemia and lethality in sepsis

Cell Reports
Summary: Sepsis, killing 11 million people yearly, is associated with increased production of lactate—a metabolite mechanistically linked to mortality—complicating glucose administration in sepsis.
Louise Nuyttens, Marah Heyerick, Geike Heremans, Elise Moens, Maxime Roes, Céline Van Dender, Liesbet De Bus, Johan Decruyenaere, Jan Dewaele, Jolien Vandewalle, Claude Libert   +10 more
doaj   +1 more source